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Chemical Compound Review:

Corrguard 75 2-amino-2-methyl-propan-1-ol

Synonyms: Amp-95, PubChem2208, AMP Regular, NSC-441, AMP (thinner), ...

Kaminski, J.J. et al., Cipolla, C. et al., Bandolet, J. et al., Rej, R., Eckstein, M. et al., et al.

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Disease relevance of AMP

Airborne contact dermatitis from 2-amino-2-methyl-1-propanol in a cosmetic company [1].
Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia [2].
The authors described two cases of airborne contact dermatitis caused by 2-amino-2-methyl-1-propanol (AMP 100) in two subjects with periorbital erythema and itching skin [1].

High impact information on AMP

There was little degradation in all of the buffers tested at 0.3 mol/L or in Tris, EAE, and 2-amino-2-methyl-1-propanol at 1.0 mol/L [3].
The behavior of some commercial lyophilized control sera differed significantly from that of patients' sera, in particular exhibiting a marked lability in the presence of 2-amino-2-methyl-1-propanol [4].
Antiarrhythmic effects of a series of N-substituted derivatives of 2-amino-2-methylpropanol were studied using isolated papillary muscle preparation of guinea-pig heart in order to evaluate the chemical structure--biological activity relationship [5].

Analytical, diagnostic and therapeutic context of AMP

Comparative antimicrobial activity studies for certain new classes of soft N-chloramines derived from alpha-aminiisobutyric acid and 2-amino-2-methyl-1-propanol were examined using the minimum inhibitory concentration (MIC) and/or the contact germicidal efficiency (CGE) procedures [6].

References

Airborne contact dermatitis from 2-amino-2-methyl-1-propanol in a cosmetic company. Cipolla, C., Belisario, A., Sassi, C., Nucci, M.C., Palermo, A., Pescarelli, A., Solina, G., Raffi, G.B. Arhiv za higijenu rada i toksikologiju. (1997) [Pubmed]
Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity. Eckstein, M., Zajaczkowska, J., Krupińska, J., Michna, M. Polish journal of pharmacology and pharmacy. (1986) [Pubmed]
Kinetic parameters for the cleaved substrate, and enzyme and substrate stability, vary with the phosphoacceptor in alkaline phosphatase catalysis. Stinson, R.A. Clin. Chem. (1993) [Pubmed]
Effect of incubation with Mg2+ on the measurement of alkaline phosphatase activity. Rej, R. Clin. Chem. (1977) [Pubmed]
Effects of antiarrhythmic drugs in the isolated papillary muscle preparation of the guinea-pig. Bandolet, J., Rump, S. Polish journal of pharmacology and pharmacy. (1989) [Pubmed]
N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems. Kaminski, J.J., Huycke, M.M., Selk, S.H., Bodor, N., Higuchi, T. Journal of pharmaceutical sciences. (1976) [Pubmed]

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