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Chemical Compound Review: 

Cyclobut-A     [2-(6-aminopurin-9-yl)-4...

Synonyms: C-Oxt-A, Cyclobut A, CHEMBL30657, AGN-PC-0018CC, SureCN1980695, ...
 
 
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Disease relevance of Carboxetanocin A

  • Administration of cyclobut G or cyclobut A at 70 mg/kg IM led to a rapid reduction of DHBV DNA to undetectable levels in serum, and in only 1 of 4 animals did DHBV DNA became detectable again within 10 days after stopping the drug.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • 9-Cyclobutyladenines bearing both methylene and hydroxymethyl groups, 3 and 4, were prepared by dehydration of carbocyclic oxetanocin A, 1a [2].

References

  1. Effects of purine nucleoside analogues with a cyclobutane ring and erythromycin A oxime derivatives on duck hepatitis B virus replication in vivo and in cell culture and HIV-1 in cell culture. Hung, L.F., Brumbaugh, A.E., Bhatia, G., Marion, P.L., Hung, P.P., Norbeck, D.W., Plattner, J.J., Robinson, W.S. J. Med. Virol. (1991) [Pubmed]
  2. Synthesis of methylenecyclobutyl- and cyclobutenyl adenine A, potent antiviral carbocyclic analogues of oxetanocin A. Maruyama, T., Hanai, Y., Sato, Y. Nucleic Acids Symp. Ser. (1991) [Pubmed]
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