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Chemical Compound Review

Cygalovir     2-amino-9-[(1R,2R,3R)-2,3...

Synonyms: LOBUCAVIR, Cyclobut-G, C-Oxt-G, C-Oxetanocin-G, CHEMBL23550, ...
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Disease relevance of LOBUCAVIR


High impact information on LOBUCAVIR


Chemical compound and disease context of LOBUCAVIR


Biological context of LOBUCAVIR


Anatomical context of LOBUCAVIR


Associations of LOBUCAVIR with other chemical compounds

  • The regional absorption of lobucavir (LBV), an experimental antiviral agent, and ganciclovir (DHPG) was investigated in rabbit intestine using an in situ single-pass perfusion technique [13].
  • Elevated AFP and BHCG levels provide prognostic information at diagnosis, indicate persistent disease following orchiectomy or RPLND, and signal a recurrence after chemotherapy [14].
  • Future investigations may furthermore help to clarify the role of novel antiviral agents, such as cidofovir, lobucavir, and compound 1263W94, and of the adoptive immunotherapy with virus-specific CTL clones in severely immunodeficient cancer patients [15].

Gene context of LOBUCAVIR

  • Changes in EPA in sera of lobucavir treated animals were comparable to changes in WHV DNA levels [16].
  • The increasing use of quantitative BHCG assay and vaginal ultrasonography have made early diagnosis possible, allowing conservative tubal surgery when indicated [17].
  • Hence every female in reproductive age group with unexplained bleeding per vaginum should be investigated with serum BHCG (Beta human chorionic gonadotrophin) [18].

Analytical, diagnostic and therapeutic context of LOBUCAVIR

  • The uterine cavity was evacuated by suction curettage after delivery and plasma, BHCG was negative 4 weeks subsequently [19].


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  2. Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro. Hayashi, S., Norbeck, D.W., Rosenbrook, W., Fine, R.L., Matsukura, M., Plattner, J.J., Broder, S., Mitsuya, H. Antimicrob. Agents Chemother. (1990) [Pubmed]
  3. Evaluation of SQ 34,514: pharmacokinetics and efficacy in experimental herpesvirus infections in mice. Braitman, A., Swerdel, M.R., Olsen, S.J., Tuomari, A.V., Lynch, J.S., Blue, B., Michalik, T., Field, A.K., Bonner, D.P., Clark, J.M. Antimicrob. Agents Chemother. (1991) [Pubmed]
  4. Management of cytomegalovirus infection after solid-organ or stem-cell transplantation. Current guidelines and future prospects. Hebart, H., Kanz, L., Jahn, G., Einsele, H. Drugs (1998) [Pubmed]
  5. In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir. Seifer, M., Hamatake, R.K., Colonno, R.J., Standring, D.N. Antimicrob. Agents Chemother. (1998) [Pubmed]
  6. Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase. Tenney, D.J., Yamanaka, G., Voss, S.M., Cianci, C.W., Tuomari, A.V., Sheaffer, A.K., Alam, M., Colonno, R.J. Antimicrob. Agents Chemother. (1997) [Pubmed]
  7. New antiherpesvirus agents. Their targets and therapeutic potential. Alrabiah, F.A., Sacks, S.L. Drugs (1996) [Pubmed]
  8. Clinical stage I testis cancer: long-term outcome of patients on surveillance. Sogani, P.C., Perrotti, M., Herr, H.W., Fair, W.R., Thaler, H.T., Bosl, G. J. Urol. (1998) [Pubmed]
  9. Efficiency of phosphorylation of the cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their anti-herpesvirus activity. Kohlbrenner, W.E., Carter, C.D., Fesik, S.W., Norbeck, D.W., Erickson, J. Biochem. Pharmacol. (1990) [Pubmed]
  10. Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture. Ying, C., De Clercq, E., Neyts, J. J. Viral Hepat. (2000) [Pubmed]
  11. Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug. Hanson, R.L., Shi, Z., Brzozowski, D.B., Banerjee, A., Kissick, T.P., Singh, J., Pullockaran, A.J., North, J.T., Fan, J., Howell, J., Durand, S.C., Montana, M.A., Kronenthal, D.R., Mueller, R.H., Patel, R.N. Bioorg. Med. Chem. (2000) [Pubmed]
  12. Prognostic value of BHCG and local tumor invasion in stage I seminoma of the testis. Schwartz, B.F., Auman, R., Peretsman, S.J., Moul, J.W., Deshon, G.E., Hernandez, J., Rozanski, R.A., Thrasher, J.B. Journal of surgical oncology. (1996) [Pubmed]
  13. In situ studies of regional absorption of lobucavir and ganciclovir from rabbit intestine and predictions of dose-limited absorption and associated variability in humans. Yang, Z., Manitpisitkul, P., Sawchuk, R.J. Journal of pharmaceutical sciences. (2006) [Pubmed]
  14. Serum markers in germ cell neoplasms. Bartlett, N.L., Freiha, F.S., Torti, F.M. Hematol. Oncol. Clin. North Am. (1991) [Pubmed]
  15. Current concepts and challenges in the prevention and treatment of viral infections in immunocompromised cancer patients. Reusser, P. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. (1998) [Pubmed]
  16. Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection. Genovesi, E.V., Lamb, L., Medina, I., Taylor, D., Seifer, M., Innaimo, S., Colonno, R.J., Clark, J.M. Antiviral Res. (2000) [Pubmed]
  17. A five-year review of ectopic pregnancy. Aboud, E. Clinical and experimental obstetrics & gynecology. (1997) [Pubmed]
  18. Management of gestational trophoblastic tumours: a five-year clinical experience. Rauf, B., Hassan, L., Ahmed, S. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. (2004) [Pubmed]
  19. Twin pregnancy involving complete hydatidiform mole and partial mole after five years of amenorrhoea. Ozumba, B.C., Ofodile, A. Eur. J. Obstet. Gynecol. Reprod. Biol. (1994) [Pubmed]
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