Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

DPMA (3R,4S,5R)-2-[6-[[2-(3,5- dimethoxyphenyl)...

Synonyms: Cgs-24012, CGS 24012, AC1L3U94, PD 125944, 120442-40-2

Webb, R.L. et al., Pechlivanova, D.M. et al.

Pechlivanova, Georgiev,

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Disease relevance of PD 125944

Dose-dependent tachycardia was seen with both CGS 21680C and CGS 24012, whereas NECA produced a biphasic response on heart rate [1].

High impact information on PD 125944

The responses to both CGS 21680C and CGS 24012 indicate that systemic vasodilation, with resultant cardioexcitation and stimulation of renin release, are the predominant hemodynamic effects of selective A2 agonists in the conscious SHR [1].
CGS 24012 reduced renal vascular resistance to the greatest extent and produced a concomitant significant increase in renal blood flow [1].
The adenosine A2A receptor agonist PD-125944 (DPMA; 0.1, 0.5 and 1 mg/kg) showed pronounced antinociceptive effect [2].

References

Cardiovascular effects of adenosine A2 agonists in the conscious spontaneously hypertensive rat: a comparative study of three structurally distinct ligands. Webb, R.L., Barclay, B.W., Graybill, S.C. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice. Pechlivanova, D.M., Georgiev, V.P. Pharmacol. Biochem. Behav. (2002) [Pubmed]

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