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Gene Review

Adora2a  -  adenosine A2a receptor

Mus musculus

Synonyms: A2AAR, A2a, Rs, A2aR, AA2AR, Adenosine receptor A2a
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Disease relevance of Adora2a


Psychiatry related information on Adora2a


High impact information on Adora2a


Chemical compound and disease context of Adora2a


Biological context of Adora2a


Anatomical context of Adora2a


Associations of Adora2a with chemical compounds


Regulatory relationships of Adora2a

  • Up to 63% of the A2AR influence was estimated to be mediated through its inhibition of the A1R antiadrenergic effect, with the remainder being the direct contractile effect [1].
  • The genetic ablation of the AC5 gene eliminated >80% of forskolin-induced AC activity and 85-90% of AC activity stimulated by either D1 or A2A receptor agonists in striatum [25].
  • Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages [24].
  • A2A receptor is highly coexpressed with enkephalin and D2 receptor in striatopallidal neurons [26].
  • CONCLUSION: The present findings suggest that the highly selective adenosine A2A receptor agonist (ATL-146e) prevents endotoxin-induced lethal liver injury by suppression of TNF-alpha secretion [27].

Other interactions of Adora2a


Analytical, diagnostic and therapeutic context of Adora2a


  1. Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts. Tikh, E.I., Fenton, R.A., Dobson, J.G. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  2. Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease. Fuxe, K., Agnati, L.F., Jacobsen, K., Hillion, J., Canals, M., Torvinen, M., Tinner-Staines, B., Staines, W., Rosin, D., Terasmaa, A., Popoli, P., Leo, G., Vergoni, V., Lluis, C., Ciruela, F., Franco, R., Ferré, S. Neurology (2003) [Pubmed]
  3. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Ledent, C., Vaugeois, J.M., Schiffmann, S.N., Pedrazzini, T., El Yacoubi, M., Vanderhaeghen, J.J., Costentin, J., Heath, J.K., Vassart, G., Parmentier, M. Nature (1997) [Pubmed]
  4. Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo. Gomez, G., Sitkovsky, M.V. Blood (2003) [Pubmed]
  5. Adenosinergic modulation of 3alpha-hydroxy-5alpha-pregnan-20-one induced catalepsy in mice. Mandhane, S.N., Khisti, R.T., Chopde, C.T. Psychopharmacology (Berl.) (1999) [Pubmed]
  6. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Huang, Z.L., Qu, W.M., Eguchi, N., Chen, J.F., Schwarzschild, M.A., Fredholm, B.B., Urade, Y., Hayaishi, O. Nat. Neurosci. (2005) [Pubmed]
  7. Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage. Fink, J.S., Kalda, A., Ryu, H., Stack, E.C., Schwarzschild, M.A., Chen, J.F., Ferrante, R.J. J. Neurochem. (2004) [Pubmed]
  8. Arterial pressure and heart rate increase during REM sleep in adenosine A2A-receptor knockout mice, but not in wild-type mice. Sakata, M., Sei, H., Eguchi, N., Morita, Y., Urade, Y. Neuropsychopharmacology (2005) [Pubmed]
  9. Expression of adenosine A2a receptors gene in the olfactory bulb and spinal cord of rat and mouse. Kaelin-Lang, A., Lauterburg, T., Burgunder, J.M. Neurosci. Lett. (1999) [Pubmed]
  10. Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity. Poleszak, E., Malec, D. Polish journal of pharmacology. (2002) [Pubmed]
  11. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Lappas, C.M., Day, Y.J., Marshall, M.A., Engelhard, V.H., Linden, J. J. Exp. Med. (2006) [Pubmed]
  12. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Carrier, E.J., Auchampach, J.A., Hillard, C.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Adenosine A2a receptors induce heterologous desensitization of chemokine receptors. Zhang, N., Yang, D., Dong, H., Chen, Q., Dimitrova, D.I., Rogers, T.J., Sitkovsky, M., Oppenheim, J.J. Blood (2006) [Pubmed]
  14. Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis. Montesinos, M.C., Desai, A., Cronstein, B.N. Arthritis Res. Ther. (2006) [Pubmed]
  15. Selective adenosine A2A receptor/dopamine D2 receptor interactions in animal models of schizophrenia. Kafka, S.H., Corbett, R. Eur. J. Pharmacol. (1996) [Pubmed]
  16. Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Chan, E.S., Fernandez, P., Merchant, A.A., Montesinos, M.C., Trzaska, S., Desai, A., Tung, C.F., Khoa, D.N., Pillinger, M.H., Reiss, A.B., Tomic-Canic, M., Chen, J.F., Schwarzschild, M.A., Cronstein, B.N. Arthritis Rheum. (2006) [Pubmed]
  17. Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease. Ikeda, K., Kurokawa, M., Aoyama, S., Kuwana, Y. J. Neurochem. (2002) [Pubmed]
  18. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Shiozaki, S., Ichikawa, S., Nakamura, J., Kitamura, S., Yamada, K., Kuwana, Y. Psychopharmacology (Berl.) (1999) [Pubmed]
  19. Receptor crosstalk: characterization of mice deficient in dopamine D1 and adenosine A2A receptors. Short, J.L., Ledent, C., Drago, J., Lawrence, A.J. Neuropsychopharmacology (2006) [Pubmed]
  20. Early occurrence of metastatic differentiated thyroid carcinomas in transgenic mice expressing the A2a adenosine receptor gene and the human papillomavirus type 16 E7 oncogene. Coppée, F., Gérard, A.C., Denef, J.F., Ledent, C., Vassart, G., Dumont, J.E., Parmentier, M. Oncogene (1996) [Pubmed]
  21. Adenosine A2A receptor gene disruption provokes marked changes in melanocortin content and pro-opiomelanocortin gene expression. Jégou, S., El Yacoubi, M., Mounien, L., Ledent, C., Parmentier, M., Costentin, J., Vaugeois, J.M., Vaudry, H. J. Neuroendocrinol. (2003) [Pubmed]
  22. Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Yu, L., Frith, M.C., Suzuki, Y., Peterfreund, R.A., Gearan, T., Sugano, S., Schwarzschild, M.A., Weng, Z., Fink, J.S., Chen, J.F. Brain Res. (2004) [Pubmed]
  23. Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. Marquardt, D.L., Walker, L.L., Heinemann, S. J. Immunol. (1994) [Pubmed]
  24. Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages. Reiss, A.B., Rahman, M.M., Chan, E.S., Montesinos, M.C., Awadallah, N.W., Cronstein, B.N. J. Leukoc. Biol. (2004) [Pubmed]
  25. Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. Lee, K.W., Hong, J.H., Choi, I.Y., Che, Y., Lee, J.K., Yang, S.D., Song, C.W., Kang, H.S., Lee, J.H., Noh, J.S., Shin, H.S., Han, P.L. J. Neurosci. (2002) [Pubmed]
  26. A2A receptor and striatal cellular functions: regulation of gene expression, currents, and synaptic transmission. Schiffmann, S.N., Dassesse, D., d'Alcantara, P., Ledent, C., Swillens, S., Zoli, M. Neurology (2003) [Pubmed]
  27. Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice. Odashima, M., Otaka, M., Jin, M., Komatsu, K., Wada, I., Matsuhashi, T., Horikawa, Y., Hatakeyama, N., Oyake, J., Ohba, R., Linden, J., Watanabe, S. J. Gastroenterol. (2005) [Pubmed]
  28. Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A receptor antagonist. Aoyama, S., Kase, H., Borrelli, E. J. Neurosci. (2000) [Pubmed]
  29. DARPP chocolate: a caffeinated morsel of striatal signaling. Bastia, E., Schwarzschild, M.A. Sci. STKE (2003) [Pubmed]
  30. Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. Ledent, C., Denef, J.F., Cottecchia, S., Lefkowitz, R., Dumont, J., Vassart, G., Parmentier, M. Endocrinology (1997) [Pubmed]
  31. Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. El Yacoubi, M., Ledent, C., Parmentier, M., Bertorelli, R., Ongini, E., Costentin, J., Vaugeois, J.M. Br. J. Pharmacol. (2001) [Pubmed]
  32. Adenosine-induced apoptosis in glomerular mesangial cells. Zhao, Z., Kapoian, T., Shepard, M., Lianos, E.A. Kidney Int. (2002) [Pubmed]
  33. Stimulation of adenosine A2A receptors elicits zif/268 and NMDA epsilon2 subunit mRNA expression in cortex and striatum of the "weaver" mutant mouse, a genetic model of nigrostriatal dopamine deficiency. Ekonomou, A., Poulou, P.D., Matsokis, N., Angelatou, F. Neuroscience (2004) [Pubmed]
  34. Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice. Pechlivanova, D.M., Georgiev, V.P. Pharmacol. Biochem. Behav. (2002) [Pubmed]
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