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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Kliojest     [(8R,9S,10R,13S,14S,17S)-17- ethynyl-13...

Synonyms: Trisekvens, Trisequens, KST-1A7479, AC1Q6OEW, AR-1A8446, ...
 
 
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High impact information on Kliojest

  • OBJECTIVES: The aim of this study was to compare a new estradiol-desogestrel (E2-DG) regimen with an E2-norethisterone acetate (NETA) combination (Trisekvens) regarding the treatment of menopausal complaints, bleeding pattern, histology of the endometrium and the occurrence of adverse experiences [1].
  • Continuous (Kliogest) and sequential (Trisequens) oestrogen-progestogen treatment were compared in a randomized, parallel, group study in women suffering from climacteric symptoms [2].
  • A double-blind, placebo-controlled study on 31 patients with osteoporotic spine fractures was performed in order to assess the effects of one-year cyclical estrogen/gestagen replacement therapy (Trisequens, Novo) on peripheral bone mineral content and bone turnover [3].

References

  1. A randomized, double-blind, multicentre study comparing the clinical effects of two sequential estradiol-progestin combinations containing either desogestrel or norethisterone acetate in climacteric women with estrogen deficiency symptoms. Saure, A., Hirvonen, E., Milsom, I., Christensen, A., Damber, M.G. Maturitas. (1996) [Pubmed]
  2. Comparison of continuous and sequential oestrogen-progestogen treatment in women with climacteric symptoms. Høvik, P., Sundsbak, H.P., Gaasemyr, M., Sandvik, L. Maturitas. (1989) [Pubmed]
  3. Effects of one-year hormone replacement therapy on peripheral bone mineral content in patients with osteoporotic spine fractures. Resch, H., Pietschmann, P., Krexner, E., Woloszczuk, W., Willvonseder, R. Acta Endocrinol. (1990) [Pubmed]
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