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Disease relevance of Climacteric

  • Hormonal changes during the menopausal transition, finally resulting in estrogen deficiency, play a pivotal role in the incidence of climacteric symptoms and also in the development of chronic diseases [1].
  • CONCLUSIONS: Tibolone seems to be an effective option for the treatment of climacteric symptoms in postmenopausal women, especially in women who do not want to experience uterine bleeding again [2].
  • These findings provide new mechanistic insights into the antiproliferative activities of CR in ER-positive and ER-negative tumour cell lines and highlight their potential in the management of climacteric disorders in women with a history of breast cancer [3].
  • However, it is suggested that the early onset and high frequency of distal radius fractures seen in climacteric Caucasian women may be more directly due to accidental falls initiated by a greater frequency, intensity, and duration of vasomotor disturbances which are known to accompanay estrogen withdrawal in perimenopausal white females [4].
  • Duodenal ulcer disease severity scores correlated with Zung SDS scores, but not with state or trait anxiety, life change units, or the FES [5].

Psychiatry related information on Climacteric


High impact information on Climacteric


Chemical compound and disease context of Climacteric


Biological context of Climacteric


Anatomical context of Climacteric


Associations of Climacteric with chemical compounds


Gene context of Climacteric


Analytical, diagnostic and therapeutic context of Climacteric


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  13. Subcutaneous hormone implants for the control of climacteric symptoms. A prospective study. Brincat, M., Magos, A., Studd, J.W., Cardozo, L.D., O'Dowd, T., Wardle, P.J., Cooper, D. Lancet (1984) [Pubmed]
  14. Expression of ACC oxidase antisense gene inhibits ripening of cantaloupe melon fruits. Ayub, R., Guis, M., Ben Amor, M., Gillot, L., Roustan, J.P., Latché, A., Bouzayen, M., Pech, J.C. Nat. Biotechnol. (1996) [Pubmed]
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  16. Panic disorder in menopause: a case control study. Claudia, P., Andrea, C., Chiara, C., Stefano, L., Giuseppe, M., Vincenzo, d.e. .L., Felice, P., Paolo, C. Maturitas. (2004) [Pubmed]
  17. Evaluation of conjugated estrogen plus medroxyprogesterone acetate versus tibolone in early postmenopausal Chinese women. Yang, T.S., Tsan, S.H., Chen, C.R., Chang, S.P., Yuan, C.C. Zhonghua Yi Xue Za Zhi (Taipei) (1999) [Pubmed]
  18. Changes in symptoms, blood pressure, glucose, hormones, and lipid levels according to weight and body fat distribution in climacteric women. Carranza-Lira, S., Murillo-Uribe, A., Martínez-Trejo, N., Santos-González, J. International journal of fertility and women's medicine. (1998) [Pubmed]
  19. Efficacy and short-term effects of pravastatin, a potent inhibitor of HMG-Co A reductase, on hypercholesterolemia in climacteric women. Ushiroyama, T., Ikeda, A., Ueki, M., Sugimoto, O. Journal of medicine. (1994) [Pubmed]
  20. Some possible gynaecological indications for peripheral antidopamine therapy. Varga, A., Lovas, J. Therapia Hungarica (English edition) (1992) [Pubmed]
  21. Androgen and estrogen-androgen hormone replacement therapy: a review of the safety literature, 1941 to 1996. Gelfand, M.M., Wiita, B. Clinical therapeutics. (1997) [Pubmed]
  22. The climacteric-like behaviour of young, mature and wounded citrus leaves. Katz, E., Riov, J., Weiss, D., Goldschmidt, E.E. J. Exp. Bot. (2005) [Pubmed]
  23. Glycolysis at the climacteric of bananas. Ball, K.L., Green, J.H., ap Rees, T. Eur. J. Biochem. (1991) [Pubmed]
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  25. Treatment with oral estrone sulphate in the female climacteric. III. Effects on bone density and on certain biochemical parameters. Lagrelius, A. Acta obstetricia et gynecologica Scandinavica. (1981) [Pubmed]
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  27. Immunocytolocalization of 1-aminocyclopropane-1-carboxylic acid oxidase in tomato and apple fruit. Rombaldi, C., Lelièvre, J.M., Latché, A., Petitprez, M., Bouzayen, M., Pech, J.C. Planta (1994) [Pubmed]
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  30. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Seidlová-Wuttke, D., Jarry, H., Becker, T., Christoffel, V., Wuttke, W. Maturitas. (2003) [Pubmed]
  31. Relation between plasma oestrone and oestradiol and climacteric symptoms. Hutton, J.D., Jacobs, H.S., Murray, M.A., James, V.H. Lancet (1978) [Pubmed]
  32. Prevention of postmenopausal bone loss using tibolone or conventional peroral or transdermal hormone replacement therapy with 17beta-estradiol and dydrogesterone. Lippuner, K., Haenggi, W., Birkhaeuser, M.H., Casez, J.P., Jaeger, P. J. Bone Miner. Res. (1997) [Pubmed]
  33. Neuropeptides in hypothalamic neuronal disorders. Swaab, D.F. Int. Rev. Cytol. (2004) [Pubmed]
  34. Alcohol and other dietary factors in relation to serum hormone concentrations in women at climacteric. London, S., Willett, W., Longcope, C., McKinlay, S. Am. J. Clin. Nutr. (1991) [Pubmed]
  35. A comparison between effects of estradiol valerate and low dose ethinyl estradiol on haemostasis parameters. Lindberg, U.B., Crona, N., Stigendal, L., Teger-Nilsson, A.C., Silfverstolpe, G. Thromb. Haemost. (1989) [Pubmed]
  36. Effect of estrogen replacement therapy on hepatic triglyceride lipase, lipoprotein lipase and lipids including apolipoprotein E in climacteric and elderly women. Urabe, M., Yamamoto, T., Kashiwagi, T., Okubo, T., Tsuchiya, H., Iwasa, K., Kikuchi, N., Yokota, K., Hosokawa, K., Honjo, H. Endocr. J. (1996) [Pubmed]
  37. Relationship between climacteric symptoms and serum galanin levels in post-menopausal women. Słopien, R., Meczekalski, B., Warenik-Szymankiewicz, A. J. Endocrinol. Invest. (2004) [Pubmed]
  38. The basal and TRH stimulated levels of prolactin in low risk climacteric patients with increased breast density: A matched pair case control trial. Soysal, S., Soysal, M.E., Karabulut, N., Gul, N., Gezgin, T. Maturitas. (2006) [Pubmed]
  39. Safety and efficacy of transdermal estradiol replacement therapy in postmenopausal liver transplanted women. A preliminary report. Appelberg, J., Isoniemi, H., Nilsson, C.G., Höckerstedt, K., Ylöstalo, P. Acta obstetricia et gynecologica Scandinavica. (1998) [Pubmed]
  40. Chai-hu-gui-zhi-gan-jiang-tang regulates plasma interleukin-6 and soluble interleukin-6 receptor concentrations and improves depressed mood in climacteric women with insomnia. Ushiroyama, T., Ikeda, A., Sakuma, K., Ueki, M. Am. J. Chin. Med. (2005) [Pubmed]
  41. A double blind cross-over study on the effects of ORG OD14 compared to estradiol valerate and placebo on the fatty acid composition of serum lecithin and cholesterol ester in oophorectomized women. Crona, N., Silfverstolpe, G., Samsioe, G. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  42. Estradiol-delivering vaginal rings for hormone replacement therapy. Nash, H.A., Alvarez-Sanchez, F., Mishell, D.R., Fraser, I.S., Maruo, T., Harmon, T.M. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  43. Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: clinical and endometrial responses. Raudaskoski, T.H., Lahti, E.I., Kauppila, A.J., Apaja-Sarkkinen, M.A., Laatikainen, T.J. Am. J. Obstet. Gynecol. (1995) [Pubmed]
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