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Chemical Compound Review:

beta-Ghmu 1-[(4S,5R)-4-hydroxy-5...

Synonyms: AC1L3XYS, AR-1E1104, beta-D-Glucosyl-hydroxymethyluracil, 5-((Glucopyranosyloxy)methyl)uracil, alpha-(beta-D-Glucopyranosyloxy)thymidine, ...

Genest, P.A. et al., Cross, M. et al., van Leeuwen, F. et al., van Leeuwen, F. et al.

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High impact information on beta-D-Glucosyl-hydroxymethyluracil

beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres [1].
The nuclear DNA of Trypanosoma brucei and other kinetoplastid flagellates contains the unusual base beta-d-glucosyl-hydroxymethyluracil, called J, replacing part of the thymine in repetitive sequences [2].
Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei [3].
In experiments with Leishmania tarentolae set up to disrupt the gene encoding the J-binding protein 1 (JBP1), a protein binding to the unusual base beta-D-glucosyl-hydroxymethyluracil (J) of Leishmania, we obtained JBP1 mutants containing linear DNA elements (amplicons) of approximately 100 kb [4].

References

beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres. van Leeuwen, F., Taylor, M.C., Mondragon, A., Moreau, H., Gibson, W., Kieft, R., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
J-binding protein increases the level and retention of the unusual base J in trypanosome DNA. Cross, M., Kieft, R., Sabatini, R., Dirks-Mulder, A., Chaves, I., Borst, P. Mol. Microbiol. (2002) [Pubmed]
Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei. van Leeuwen, F., Kieft, R., Cross, M., Borst, P. Mol. Biochem. Parasitol. (2000) [Pubmed]
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania. Genest, P.A., ter Riet, B., Dumas, C., Papadopoulou, B., van Luenen, H.G., Borst, P. Nucleic Acids Res. (2005) [Pubmed]

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