Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AR-1K8958 3,5-dioxooctanedioic acid

Synonyms: AC1L2O5E, AC1Q5GU6, 65115-74-4, Succinylacetoacetate, Succinyl-acetoacetate, ...

Fällström, S.P. et al., Lindstedt, S. et al.

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Disease relevance of Succinylacetoacetate

On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone [1].

High impact information on Succinylacetoacetate

The excretion of succinylacetoacetate and succinylacetone decreased from 15-103 mmol/mol creatinine to the detection limit or slightly above (ie, to 20-150 mumol/mol creatinine) [2].
Phenylalanine and homogentisate increase the concentration of succinylacetoacetate and succinylacetone both in serum and urine in patients with hereditary tyrosinemia and therefore increase the excretion of 5-aminolevulinate [1].

References

On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone. Fällström, S.P., Lindblad, B., Steen, G. Acta paediatrica Scandinavica. (1981) [Pubmed]
Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase. Lindstedt, S., Holme, E., Lock, E.A., Hjalmarson, O., Strandvik, B. Lancet (1992) [Pubmed]

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