Chemical Compound Review:
homogentisate 2-(2,5- dihydroxyphenyl)ethanoate
Synonyms:
CHEBI:16169, AC1NUT64, ZINC00388428, c0108, A826718, ...
This record was replaced with 780.
- Mutation and polymorphism analysis of the human homogentisate 1, 2-dioxygenase gene in alkaptonuria patients. Beltrán-Valero de Bernabé, D., Granadino, B., Chiarelli, I., Porfirio, B., Mayatepek, E., Aquaron, R., Moore, M.M., Festen, J.J., Sanmartí, R., Peñalva, M.A., de Córdoba, S.R. Am. J. Hum. Genet. (1998)
- Fungal metabolic model for human type I hereditary tyrosinaemia. Fernández-Cañón, J.M., Peñalva, M.A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues. Fernández-Cañón, J.M., Peñalva, M.A. J. Biol. Chem. (1995)
- The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida. Arias-Barrau, E., Olivera, E.R., Luengo, J.M., Fernández, C., Galán, B., García, J.L., Díaz, E., Miñambres, B. J. Bacteriol. (2004)
- Catabolism of L-tyrosine by the homoprotocatechuate pathway in gram-positive bacteria. Sparnins, V.L., Chapman, P.J. J. Bacteriol. (1976)
- Crystal structure of human homogentisate dioxygenase. Titus, G.P., Mueller, H.A., Burgner, J., Rodríguez De Córdoba, S., Peñalva, M.A., Timm, D.E. Nat. Struct. Biol. (2000)
- A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice. Sun, M.S., Hattori, S., Kubo, S., Awata, H., Matsuda, I., Endo, F. J. Am. Soc. Nephrol. (2000)
- The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Fritze, I.M., Linden, L., Freigang, J., Auerbach, G., Huber, R., Steinbacher, S. Plant Physiol. (2004)
- Catalytic, noncatalytic, and inhibitory phenomena: kinetic analysis of (4-hydroxyphenyl)pyruvate dioxygenase from Arabidopsis thaliana. Purpero, V.M., Moran, G.R. Biochemistry (2006)
- L-Phenylalanine and L-tyrosine catabolism by selected Streptomyces species. Pometto, A.L., Crawford, D.L. Appl. Environ. Microbiol. (1985)
- Some kinetic properties of 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P.J. 874. Rundgren, M. Eur. J. Biochem. (1983)
- Degradation of homogentisate by strains of Bacillus and Moraxella. Crawford, R.L. Can. J. Microbiol. (1976)
- On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone. Fällström, S.P., Lindblad, B., Steen, G. Acta paediatrica Scandinavica. (1981)
- Alkaptonuria, ochronosis, and ochronotic arthropathy. Mannoni, A., Selvi, E., Lorenzini, S., Giorgi, M., Airó, P., Cammelli, D., Andreotti, L., Marcolongo, R., Porfirio, B. Semin. Arthritis Rheum. (2004)
- Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution. O'Hare, H.M., Huang, F., Holding, A., Choroba, O.W., Spencer, J.B. FEBS Lett. (2006)
- The Sinorhizobium meliloti nutrient-deprivation-induced tyrosine degradation gene hmgA is controlled by a novel member of the arsR family of regulatory genes. Milcamps, A., Struffi, P., de Bruijn, F.J. Appl. Environ. Microbiol. (2001)
- Gene expression profiles of homogentisate-treated Fah-/- Hpd-/-mice using DNA microarrays. Tanaka, Y., Nakamura, K., Matsumoto, S., Kimoto, Y., Tanoue, A., Tsujimoto, G., Endo, F. Mol. Genet. Metab. (2006)
- Metabolism of L-phenylalanine and L-tyrosine by the phototrophic bacterium Rhodobacter capsulatus. Sáez, L.P., Castillo, F., Caballero, F.J. Curr. Microbiol. (1999)
- Tocopherol synthesis from homogentisate in Capsicum anuum L. (yellow pepper) chromoplast membranes: evidence for tocopherol cyclase. Arango, Y., Heise, K.P. Biochem. J. (1998)
- Tyrosinaemia type I and apoptosis of hepatocytes and renal tubular cells. Endo, F., Sun, M.S. J. Inherit. Metab. Dis. (2002)
- Concentrations of succinylacetone after homogentisate and tyrosine loading in healthy individuals with low fumarylacetoacetase activity. Kvittingen, E.A., Leonard, J.V., Pettit, B.R., King, G.S. Clin. Chim. Acta (1985)
- Comparative tyrosine degradation in Vibrio cholerae strains. The strain ATCC 14035 as a prokaryotic melanogenic model of homogentisate-releasing cell. Sanchez-Amat, A., Ruzafa, C., Solano, F. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998)
- Inhibition of protein and aminoacyl-tRNA synthesis, and binding and transport sites for aromatic amino acids in the brain in vitro with aromatic acids. Lähdesmäki, P. Int. J. Neurosci. (1984)
- Structural and functional analysis of mutations in alkaptonuria. Rodríguez, J.M., Timm, D.E., Titus, G.P., Beltrán-Valero De Bernabé, D., Criado, O., Mueller, H.A., Rodríguez De Córdoba, S., Peñalva, M.A. Hum. Mol. Genet. (2000)
- Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway. Endo, F., Kubo, S., Awata, H., Kiwaki, K., Katoh, H., Kanegae, Y., Saito, I., Miyazaki, J., Yamamoto, T., Jakobs, C., Hattori, S., Matsuda, I. J. Biol. Chem. (1997)
- Aerobic metabolism of phenylacetic acids in Azoarcus evansii. Mohamed, M.e.l.-.S., Ismail, W., Heider, J., Fuchs, G. Arch. Microbiol. (2002)
- Isolation and properties of gamma-tocopherol methyltransferase in Euglena gracilis. Shigeoka, S., Ishiko, H., Nakano, Y., Mitsunaga, T. Biochim. Biophys. Acta (1992)
- Mode of action of 4-hydroxyphenylpyruvate dioxygenase inhibition by triketone-type inhibitors. Wu, C.S., Huang, J.L., Sun, Y.S., Yang, D.Y. J. Med. Chem. (2002)
- 4-Hydroxyphenylpyruvate dioxygenase. Moran, G.R. Arch. Biochem. Biophys. (2005)
- The determination of flux through phenylalanine hydroxylase and homogentisate oxidase in isolated hepatocytes. Fisher, M.J., Pogson, C.I. Biosci. Rep. (1984)
- Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Gunsior, M., Ravel, J., Challis, G.L., Townsend, C.A. Biochemistry (2004)