Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

WS-7528 (2S,3S)-5,7-dihydroxy-2-(4- hydroxyphenyl)...

Synonyms: AC1L2OPQ, WS 7528, BE 14348B, BE 14348C, 132147-69-4, ...

Nakayama, O. et al.

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Disease relevance of WS-7528

WS-7528, produced by Streptomyces sp. No. 7528, was extracted from cultured broth, purified by solvent extraction followed by chromatography on silica gel and then isolated as pale yellow powder (C16H14O5, mp 95-98 degrees C) [1].
WS-7528 has also weak anti-inflammatory activity on the carrageenin paw edema of the rat model [1].

High impact information on WS-7528

The IC50 value of WS-7528 for partially purified rat uterine cytosol receptor was 5.7 x 10(-8) M [1].
WS-7528 was tested orally and subcutaneously in immature rats to confirm its effect on the growth of the uterus [1].

References

WS-7528, a new isoflavanone with estrogen activity isolated from Streptomyces sp. No. 7528. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. Nakayama, O., Yagi, M., Tanaka, M., Kiyoto, S., Uchida, I., Hashimoto, M., Okuhara, M., Kohsaka, M. J. Antibiot. (1990) [Pubmed]

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