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Chemical Compound Review

Esterastin     1-(3-hexyl-4-oxo-oxetan-2- yl)trideca-4,7...

Synonyms: AC1L2OYT, LS-22049, C28H46N2O6
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Disease relevance of Esterastin


High impact information on Esterastin

  • The limiting membrane, however, could not be observed after further incubation for 48 h in the presence of esterastin, which is known to be an inhibitor of lipase and esterase [2].
  • Esterastin inhibited the enzyme activity very strongly (IC50, about 80 nM) [3].
  • Rabbit aortic smooth muscle cells in culture were incubated with 0.04-500 M esterastin [4].
  • The effects of esterastin, an acid lipase inhibitor, on the free and esterified cholesterol contents of cultured smooth muscle cells from pig aorta were examined [5].


  1. Esterastin, an inhibitor of esterase, produced by actinomycetes. Umezawa, H., Aoyagi, T., Hazato, T., Uotani, K., Kojima, F., Hamada, M., Takeuchi, T. J. Antibiot. (1978) [Pubmed]
  2. Intracellular transport of cholesteryl esters from lysosomes to cytoplasm in macrophages. Mineo, C., Kanaseki, T., Enomoto, M., Ohkuma, S., Takano, T. Cell Struct. Funct. (1988) [Pubmed]
  3. Esterastin: a potent inhibitor of lysosomal acid lipase. Imanaka, T., Moriyama, Y., Ecsedi, G.G., Aoyagi, T., Amanuma-Muto, K., Ohkuma, S., Takano, T. J. Biochem. (1983) [Pubmed]
  4. Relative specificities of inhibition of acid cholesteryl ester hydrolase and neutral cholesteryl ester hydrolase in cultured rabbit aortic smooth muscle cells by esterastin and cholesteryl oleyl ether. Morin, R.J., Peng, S.K. Biochim. Biophys. Acta (1989) [Pubmed]
  5. Effect of esterastin, an acid lipase inhibitor, on the free and esterified cholesterol contents of cultured aortic smooth muscle cells treated with LDL and cholesterol ester liquid crystals. Ecsedi, G.G., Amanuma, K., Imanaka, T., Aoyagi, T., Ohkuma, S., Takano, T. Biochem. Int. (1985) [Pubmed]
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