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Ces1c  -  carboxylesterase 1C

Mus musculus

Synonyms: Carboxylesterase 1C, Ces-N, Ee-1, Ee1, Es-1, ...
 
 
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Disease relevance of Es1

  • None of the lymphomas stained with T-cell antibodies or the esterase; 15 did not stain for immunoglobulin, but 13 of these 15 did express Ia antigen [1].
  • These results favor the hypothesis that esterase inhibition leads to an agonist-induced myopathy, which is mediated by Ca++ and requires an intact AChR [2].
  • In mice whose oxidative metabolism had been increased with beta-ionone or in which esterase metabolism had been inhibited by diazinon, the severity of the toxicity was increased but the intraacinar origin of the lesion did not change [3].
  • Both compounds inhibited the growth of preestablished 4T1 tumors when given i.p. However, when given by oral gavage, only the esterase-resistant Valpha-TEA was able to suppress primary tumor growth and reduce lung metastasis [4].
  • In the accompanying paper (Shi, W.-X., Chammas, R., and Varki, A. (1996) J. Biol. Chem. 261, 31517-31525), we report that the extent of 9-O-acetylation of cell surface sialic acids on murine erythroleukemia (MEL) cells can be modified by various manipulations, including differentiation, nocodazole treatment, and 9-O-acetyl esterase treatment [5].
 

Psychiatry related information on Es1

  • This metabolic pathway is normally a minor one in humans, but takes on significance when metabolism of cocaine by the P-450 system is increased, as may occur with excessive alcohol consumption (enzyme induction) or after exposure to organophosphate pesticides (esterase inhibition) [6].
 

High impact information on Es1

 

Chemical compound and disease context of Es1

 

Biological context of Es1

 

Anatomical context of Es1

  • This protein, like mouse egasyn, has esterase catalytic activity and is concentrated in microsomes [16].
  • Since killer-specific esterases and channel-forming proteins can be demonstrated in in vitro cell lines, it is important to ascertain that the described esterase and channel-forming proteins are also present in killer cells from in vivo sources [17].
  • Most of the colonies consisted exclusively of large, dispersed macrophages that were intensely stained for nonspecific esterase [18].
  • The expressed protein showed a granular pattern in intracellular distribution, was fractionated at the density of lysosomes, and had serine esterase activities; acid carboxypeptidase at pH 5.6, esterase at pH 7.0, and carboxyl-terminal deamidase at pH 7 [19].
  • A significant portion of murine hepatocyte beta-glucuronidase is maintained within the endoplasmic reticulum (ER) by complex formation with the esterase active site of the protein egasyn [20].
 

Associations of Es1 with chemical compounds

  • Kidney expression of the electrophoretic esterase band controlled by the Es-6 locus is sex influenced, with increased activity apparently induced by testosterone [21].
  • With three of the substrates (alpha-naphthyl acetate and esters 2 and 3), esterase activity was the same in both groups; however, with the others (rho-nitrophenyl acetate and esters 1 and 4), there was a small increase in activity in ovariectomized females, compared with intact females [22].
  • These results indicate that clofibrate causes significant alterations in the regulation of esterase activity, whereas sex hormones only cause small changes [22].
  • Esterase 1 (Es-1) is a sexually dimorphic 65-kDa glycoprotein present in plasma and other murine tissues able to hydrolyze a variety of esters including fatty acid esters of estradiol [23].
  • Assay of different cytotoxic effector cells reveals the presence of N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase in clones with T killer and NK activity, but enzyme levels do not correlate with cytolytic activity nor does inhibition of esterase activity interfere with granule-mediated cell lysis [17].
 

Regulatory relationships of Es1

  • BSF-1 plus PMA stimulated a significant increase in the intracellular content of N-benzyloxycarbonyl-L-lysine thiobenzylester esterase, a granule-associated biochemical marker, whereas IL-2 plus PMA was only marginally effective [24].
  • Inhibition of amyloid formation was dependent on the molar ratio AChE:mAb 25B1, and at least 50% of the inhibition of the AChE promoting effect occurs at a molar ratio similar to that required for inhibition of the esterase activity [25].
  • The esterase was found to increase markedly the mEGF-induced incorporation of glucosamine into extracellular hyaluronic acid, while the addition of ascorbic acid did not significantly alter glucosamine incorporation [26].
  • Although originally described as mouse B lymphocytes, the IIA1.6 cells proved positive for non-specific esterase activity and expressed the CD5 antigen [27].
 

Other interactions of Es1

 

Analytical, diagnostic and therapeutic context of Es1

References

  1. Immunologic phenotype in 30 patients with diffuse large-cell lymphoma. Warnke, R., Miller, R., Grogan, T., Pederson, M., Dilley, J., Levy, R. N. Engl. J. Med. (1980) [Pubmed]
  2. Agonist-induced myopathy at the neuromuscular junction is mediated by calcium. Leonard, J.P., Salpeter, M.M. J. Cell Biol. (1979) [Pubmed]
  3. Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis. Roth, L., Harbison, R.D., James, R.C., Tobin, T., Roberts, S.M. Hepatology (1992) [Pubmed]
  4. Dietary Administration of the Proapoptotic Vitamin E Analogue {alpha}-Tocopheryloxyacetic Acid Inhibits Metastatic Murine Breast Cancer. Hahn, T., Szabo, L., Gold, M., Ramanathapuram, L., Hurley, L.H., Akporiaye, E.T. Cancer Res. (2006) [Pubmed]
  5. Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing. Shi, W.X., Chammas, R., Varki, N.M., Powell, L., Varki, A. J. Biol. Chem. (1996) [Pubmed]
  6. Alternations in splenocyte and thymocyte subpopulations in B6C3F1 mice exposed to cocaine plus diazinon. Kump, D.F., Matulka, R.A., Burton, G.F., Jordan, S.D., Holsapple, M.P. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  7. Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase. Varki, A., Hooshmand, F., Diaz, S., Varki, N.M., Hedrick, S.M. Cell (1991) [Pubmed]
  8. Involvement of the esterase active site of egasyn in compartmentalization of beta-glucuronidase within the endoplasmic reticulum. Medda, S., Stevens, A.M., Swank, R.T. Cell (1987) [Pubmed]
  9. Monoclonal antibody A2B5, which detects cell surface antigens, binds to ganglioside GT3 (II3 (NeuAc)3LacCer) and to its 9-O-acetylated derivative. Dubois, C., Manuguerra, J.C., Hauttecoeur, B., Maze, J. J. Biol. Chem. (1990) [Pubmed]
  10. Specific esterase activity induced in mouse Friend erythroleukemia cells by dimethylsulfoxide. Revoltella, R.P., Bertolini, L., Fioritoni, G., Torlontano, G. J. Cell. Physiol. (1979) [Pubmed]
  11. Resident macrophage proliferation in mice depleted of blood monocytes by strontium-89. Sawyer, R.T., Strausbauch, P.H., Volkman, A. Lab. Invest. (1982) [Pubmed]
  12. Characterization and functional expression of a cDNA encoding egasyn (esterase-22): the endoplasmic reticulum-targeting protein of beta-glucuronidase. Ovnic, M., Swank, R.T., Fletcher, C., Zhen, L., Novak, E.K., Baumann, H., Heintz, N., Ganschow, R.E. Genomics (1991) [Pubmed]
  13. Es-6, a further polymorphic esterase in the rat. Bender, K., Nagel, M., Günther, E. Biochem. Genet. (1982) [Pubmed]
  14. Genetic characterization of esterase 28 (ES-28) of the house mouse. von Deimling, O.H., Wassmer, B. Biochem. Genet. (1991) [Pubmed]
  15. Esterase-23 (ES-23): characterization of a new carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, genetically linked to ES-2 on chromosome 8. von Deimling, O.H. Biochem. Genet. (1984) [Pubmed]
  16. An accessory protein identical to mouse egasyn is complexed with rat microsomal beta-glucuronidase and is identical to rat esterase-3. Medda, S., Takeuchi, K., Devore-Carter, D., von Deimling, O., Heymann, E., Swank, R.T. J. Biol. Chem. (1987) [Pubmed]
  17. High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells. Dennert, G., Anderson, C.G., Prochazka, G. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  18. Inducible production of human macrophage growth factor, CSF-1. Ralph, P., Warren, M.K., Lee, M.T., Csejtey, J., Weaver, J.F., Broxmeyer, H.E., Williams, D.E., Stanley, E.R., Kawasaki, E.S. Blood (1986) [Pubmed]
  19. Purification and characterization of human lysosomal protective protein expressed in stably transformed Chinese hamster ovary cells. Itoh, K., Takiyama, N., Kase, R., Kondoh, K., Sano, A., Oshima, A., Sakuraba, H., Suzuki, Y. J. Biol. Chem. (1993) [Pubmed]
  20. The propeptide of beta-glucuronidase. Further evidence of its involvement in compartmentalization of beta-glucuronidase and sequence similarity with portions of the reactive site region of the serpin superfamily. Li, H., Takeuchi, K.H., Manly, K., Chapman, V., Swank, R.T. J. Biol. Chem. (1990) [Pubmed]
  21. Esterase-6 (Es-6) in laboratory mice: hormone-influenced expression and linkage relationship to oligosyndactylism (Os), esterase-1 (Es-1), and esterase-2 (Es-2) in chromosome 8. Womack, J.E. Biochem. Genet. (1975) [Pubmed]
  22. Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones. Parker, A.G., Pinot, F., Grant, D.F., Spearow, J., Hammock, B.D. Biochem. Pharmacol. (1996) [Pubmed]
  23. Esterase-1: developmental expression in the mouse and distribution of related proteins in other species. Kadner, S.S., Katz, J., Finlay, T.H. Arch. Biochem. Biophys. (1992) [Pubmed]
  24. B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes. Trenn, G., Takayama, H., Hu-Li, J., Paul, W.E., Sitkovsky, M.V. J. Immunol. (1988) [Pubmed]
  25. A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme. Reyes, A.E., Perez, D.R., Alvarez, A., Garrido, J., Gentry, M.K., Doctor, B.P., Inestrosa, N.C. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  26. Enhanced synthesis and extracellular accumulation of hyaluronic acid during stimulation of quiescent human fibroblasts by mouse epidermal growth factor. Lembach, K.J. J. Cell. Physiol. (1976) [Pubmed]
  27. FcgammaRIa-gamma-chain complexes trigger antibody-dependent cell-mediated cytotoxicity (ADCC) in CD5+ B cell/macrophage IIA1.6 cells. Van Vugt, M.J., Van den Herik-Oudijk, I.E., Van de Winkel, J.G. Clin. Exp. Immunol. (1998) [Pubmed]
  28. Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency. Beamer, W.G., Sweet, H.O., Bronson, R.T., Shire, J.G., Orth, D.N., Davisson, M.T. J. Endocrinol. (1994) [Pubmed]
  29. Esterase. XXI. Es-9, a possibly new polymorphic esterase in Mus musculus genetically linked to es-2. Schollen, J., Bender, K., von Deimling, O. Biochem. Genet. (1975) [Pubmed]
  30. Polymorphism of esterase 11 in Mus musculus, a further esterase locus on chromosome 8. Peters, J., Nash, H.R. Biochem. Genet. (1977) [Pubmed]
  31. Assignment of the gene for adenine phosphoribosyltransferase on the genetic map of mouse chromosome 8. Nesterova, T.B., Borodin, P.M., Zakian, S.M., Serov, O.L. Biochem. Genet. (1987) [Pubmed]
  32. Purification and characterization of esterase 1F, the albumin esterase of the house mouse (Mus musculus). Otto, J., Ronai, A., von Deimling, O. Eur. J. Biochem. (1981) [Pubmed]
  33. Esterase-29 (ES-29): biochemical characterization and control by two independent gene loci of a testosterone-dependent mouse serum esterase. von Deimling, O., Gaa, A. Biochem. Genet. (1992) [Pubmed]
  34. Molecular cloning, characterization, and differential expression pattern of mouse lung surfactant convertase. Krishnasamy, S., Teng, A.L., Dhand, R., Schultz, R.M., Gross, N.J. Am. J. Physiol. (1998) [Pubmed]
 
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