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Chemical Compound Review

Agaricin     2-hydroxynonadecane-1,2,3- tricarboxylic acid

Synonyms: Agaricinsaeure, Agaricic acid, Laricic acid, CHEMBL78764, Agaric acid, ...
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High impact information on NSC60429

  • Two other tricarboxylic acids, agaric acid and (-)-hydroxycitrate, were found to inhibit PFK [1].
  • Agaricic acid, a potent inhibitor of various glycosomal enzymes of T. brucei, has also a strong, irreversible effect on glucose-6-phosphate isomerase, while leaving the yeast and mammalian enzymes relatively unaffected [2].
  • The effect of agaric acid on citrate transport in rat liver mitochondria [3].
  • Inhibition of de novo fatty-acid biosynthesis, by in vivo injection of hydroxycitric acid and inclusion of agaric acid in the type II cell culture medium, abolished the increase in cytidylyltransferase activity on day 3 but not FAS and had no effect on activities of two other enzymes of phospholipid synthesis [4].


  1. Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase. McCune, S.A., Foe, L.G., Kemp, R.G., Jurin, R.R. Biochem. J. (1989) [Pubmed]
  2. Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme. Marchand, M., Kooystra, U., Wierenga, R.K., Lambeir, A.M., Van Beeumen, J., Opperdoes, F.R., Michels, P.A. Eur. J. Biochem. (1989) [Pubmed]
  3. The effect of agaric acid on citrate transport in rat liver mitochondria. Chávez, E., Chávez, R., Carrasco, N. Life Sci. (1978) [Pubmed]
  4. Fatty-acid synthase activity and mRNA level in hypertrophic type II cells from silica-treated rats. Rami, J., Stenzel, W., Sasic, S.M., Puel-M'Rini, C., Besombes, J.P., Elias, J.A., Rooney, S.A. Am. J. Physiol. (1994) [Pubmed]
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