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MeSH Review

Mitochondria, Liver

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Disease relevance of Mitochondria, Liver


Psychiatry related information on Mitochondria, Liver


High impact information on Mitochondria, Liver


Chemical compound and disease context of Mitochondria, Liver


Biological context of Mitochondria, Liver


Anatomical context of Mitochondria, Liver


Associations of Mitochondria, Liver with chemical compounds


Gene context of Mitochondria, Liver

  • Using Western analysis and immunogold labeling, A-RAF was selectively localized in highly purified rat liver mitochondria [32].
  • MAO A-3C9 appears to have a lower affinity for purified MAO A than the other three antibodies and does not immunoprecipitate either MAO A or MAO B from human platelets or from Triton X-100 extracts of human placental and liver mitochondria [33].
  • Given published evidence that NF kappaB is antiapoptotic and that UCP-2 may decrease mitochondrial oxidant production in some cells, these results suggest that TNF-dependent increases in oxidant production by liver mitochondria promote the induction of antioxidant defenses in the regenerating liver [34].
  • However, the level of total glutathione was 30% less in liver mitochondria of the Sod2(-/+) mice [35].
  • Moreover, the liver mitochondria were found to release markedly increased hydrogen peroxide, a Gpx1 substrate, and have decreased mitochondrial respiratory control ratio and power output index [36].

Analytical, diagnostic and therapeutic context of Mitochondria, Liver


  1. Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia. Coude, F.X., Sweetman, L., Nyhan, W.L. J. Clin. Invest. (1979) [Pubmed]
  2. Cholestasis confers resistance to the rat liver mitochondrial permeability transition. Lieser, M.J., Park, J., Natori, S., Jones, B.A., Bronk, S.F., Gores, G.J. Gastroenterology (1998) [Pubmed]
  3. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Zhao, P., Kalhorn, T.F., Slattery, J.T. Hepatology (2002) [Pubmed]
  4. Submicromolar Ca2+ regulates phosphorylating respiration by normal rat liver and AS-30D hepatoma mitochondria by different mechanisms. Murphy, A.N., Kelleher, J.K., Fiskum, G. J. Biol. Chem. (1990) [Pubmed]
  5. Ultrastructural and biochemical aspects of liver mitochondria during recovery from ethanol-induced alterations. Experimental evidence of mitochondrial division. Koch, O.R., Roatta de Conti, L.L., Bolaños, L.P., Stoppani, A.O. Am. J. Pathol. (1978) [Pubmed]
  6. Diurnal changes in succinate and D-3-hydroxybutyrate dehydrogenase activities of rat liver mitochondria after chronic alcohol consumption and withdrawal. Kaminsky, Y.G., Kosenko, E.A. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1988) [Pubmed]
  7. Fumarase deficiency: a new cause of mitochondrial encephalomyopathy. Zinn, A.B., Kerr, D.S., Hoppel, C.L. N. Engl. J. Med. (1986) [Pubmed]
  8. Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody. Denney, R.M., Fritz, R.R., Patel, N.T., Abell, C.W. Science (1982) [Pubmed]
  9. Lack of correlation between hepatic mitochondrial membrane structure and functions in ethanol-fed rats. Gordon, E.R., Rochman, J., Arai, M., Lieber, C.S. Science (1982) [Pubmed]
  10. Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption. Hasumura, Y., Teschke, R., Lieber, C.S. Science (1975) [Pubmed]
  11. Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria. Krahenbuhl, S., Ray, D.B., Stabler, S.P., Allen, R.H., Brass, E.P. J. Clin. Invest. (1990) [Pubmed]
  12. [14C]palmitate uptake in isolated rat liver mitochondria: effects of fasting, diabetes mellitus, and inhibitors of carnitine acyltransferase. Amatruda, J.M., Lockwood, D.H., Margolis, S., Kiesow, L.A. J. Lipid Res. (1978) [Pubmed]
  13. Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis. Krähenbühl, L., Ledermann, M., Lang, C., Krähenbühl, S. J. Hepatol. (2000) [Pubmed]
  14. Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria. Spaniol, M., Bracher, R., Ha, H.R., Follath, F., Krähenbühl, S. J. Hepatol. (2001) [Pubmed]
  15. Neonatal hypoxia or maternal diabetes delays postnatal development of liver mitochondria. Aprille, J.R., Nosek, M.T. Pediatr. Res. (1987) [Pubmed]
  16. Refsum disease diagnostic marker phytanic acid alters the physical state of membrane proteins of liver mitochondria. Schönfeld, P., Struy, H. FEBS Lett. (1999) [Pubmed]
  17. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Berson, A., De Beco, V., Lettéron, P., Robin, M.A., Moreau, C., El Kahwaji, J., Verthier, N., Feldmann, G., Fromenty, B., Pessayre, D. Gastroenterology (1998) [Pubmed]
  18. Reversible uncoupling of oxidative phosphorylation at low oxygen tension. Kramer, R.S., Pearlstein, R.D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  19. AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity. Sun, X., Wong, J.R., Song, K., Hu, J., Garlid, K.D., Chen, L.B. Cancer Res. (1994) [Pubmed]
  20. Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Byczkowski, J.Z., Zychlinski, L., Porter, C.W. Cancer Res. (1982) [Pubmed]
  21. Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. de Souza-Pinto, N.C., Eide, L., Hogue, B.A., Thybo, T., Stevnsner, T., Seeberg, E., Klungland, A., Bohr, V.A. Cancer Res. (2001) [Pubmed]
  22. Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs. Rottenberg, H., Waring, A., Rubin, E. Science (1981) [Pubmed]
  23. Biosynthesis of 5-aminolevulinic acid and heme from 4,5-dioxovalerate in the rat. Morton, K.A., Kushner, J.P., Straka, J.G., Burnham, B.F. J. Clin. Invest. (1983) [Pubmed]
  24. High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Mårtensson, J., Lai, J.C., Meister, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  25. Zinc metallothionein imported into liver mitochondria modulates respiration. Ye, B., Maret, W., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Characterization of a protease apparently involved in processing of pre-ornithine transcarbamylase of rat liver. Mori, M., Miura, S., Tatibana, M., Cohen, P.P. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  27. Bile acid synthesis during development. Mitochondrial 12 alpha-hydroxylation in human fetal liver. Gustafsson, J. J. Clin. Invest. (1985) [Pubmed]
  28. Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice. Yamamoto, M., Miura, N., Ohtake, N., Amagaya, S., Ishige, A., Sasaki, H., Komatsu, Y., Fukuda, K., Ito, T., Terasawa, K. Gastroenterology (2000) [Pubmed]
  29. Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction. Berson, A., Renault, S., Lettéron, P., Robin, M.A., Fromenty, B., Fau, D., Le Bot, M.A., Riché, C., Durand-Schneider, A.M., Feldmann, G., Pessayre, D. Gastroenterology (1996) [Pubmed]
  30. Submitochondrial localization and function of enzymes of glutamine metabolism in avian liver. Vorhaben, J.E., Campbell, J.W. J. Cell Biol. (1977) [Pubmed]
  31. Mitochondrial respiratory inhibition by N-methylated beta-carboline derivatives structurally resembling N-methyl-4-phenylpyridine. Albores, R., Neafsey, E.J., Drucker, G., Fields, J.Z., Collins, M.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  32. Isoform-specific localization of A-RAF in mitochondria. Yuryev, A., Ono, M., Goff, S.A., Macaluso, F., Wennogle, L.P. Mol. Cell. Biol. (2000) [Pubmed]
  33. Immunological uniqueness of human monoamine oxidases A and B: new evidence from studies with monoclonal antibodies to human monoamine oxidase A. Kochersperger, L.M., Waguespack, A., Patterson, J.C., Hsieh, C.C., Weyler, W., Salach, J.I., Denney, R.M. J. Neurosci. (1985) [Pubmed]
  34. Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. Lee, F.Y., Li, Y., Zhu, H., Yang, S., Lin, H.Z., Trush, M., Diehl, A.M. Hepatology (1999) [Pubmed]
  35. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. Williams, M.D., Van Remmen, H., Conrad, C.C., Huang, T.T., Epstein, C.J., Richardson, A. J. Biol. Chem. (1998) [Pubmed]
  36. Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Esposito, L.A., Kokoszka, J.E., Waymire, K.G., Cottrell, B., MacGregor, G.R., Wallace, D.C. Free Radic. Biol. Med. (2000) [Pubmed]
  37. Identification of folate binding protein of mitochondria as dimethylglycine dehydrogenase. Wittwer, A.J., Wagner, C. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  38. Isovaleryl-CoA dehydrogenase: demonstration in rat liver mitochondria by ion exchange chromatography and isoelectric focusing. Noda, C., Rhead, W.J., Tanaka, K. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  39. An oxidative damage-specific endonuclease from rat liver mitochondria. Croteau, D.L., ap Rhys, C.M., Hudson, E.K., Dianov, G.L., Hansford, R.G., Bohr, V.A. J. Biol. Chem. (1997) [Pubmed]
  40. A hydrophobic protein, chargerin II, purified from rat liver mitochondria is encoded in the unidentified reading frame A6L of mitochondrial DNA. Higuti, T., Negama, T., Takigawa, M., Uchida, J., Yamane, T., Asai, T., Tani, I., Oeda, K., Shimizu, M., Nakamura, K. J. Biol. Chem. (1988) [Pubmed]
  41. Adenosine triphosphatase from rat liver mitochondria. Crystallization and x-ray diffraction studies of the F1-component of the enzyme. Amzel, L.M., Pedersen, P.L. J. Biol. Chem. (1978) [Pubmed]
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