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Chemical Compound Review:

PubChem9286 3-hydroxypyridine-2-carboxylic acid

Synonyms: SureCN78249, AG-B-97190, AG-H-52766, CHEMBL1234326, ACMC-209qln, ...

Zhou, L. et al., Wu, K.J. et al., Kong, Y. et al., Lichtenwalter, K.G. et al., Bai, J. et al., et al.

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Disease relevance of NSC82843

A 3-hydroxypicolinic acid activating enzyme from etamycin producing Streptomyces griseoviridus has been purified to apparent homogeneity [1].

High impact information on NSC82843

A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides [2].
A mixed matrix of 3-hydroxypicolinic acid (3-HPA) and pyrazinecarboxylic acid (PCA) was used for analysis of a variety of synthetic oligodeoxynucleotides ranging in length from 8-108-mers by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [2].
Experimental results of the protonation and deprotonation of the bases of A, T, G and C in the matrices 2,5-dihydroxybenzoic acid (2,5-DHB), alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) and 3-hydroxypicolinic acid (3-HPA) provide an insight into the ionization mechanism of oligonucleotides in MALDI [3].
We report the first detection of DNA segments as large as 500 nucleotides by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, using picolinic acid and 3-hydroxypicolinic acid mixtures as desorption matrices [4].
Matrix-assisted laser desorption/ionization using a 3-hydroxypicolinic acid matrix from an active Nafion substrate has been used for detection of restriction enzyme-digested double-stranded plasmid DNA using time-of-flight mass spectrometry [5].

Biological context of NSC82843

Subsequently, the small fragments derived from the 3' ends of the molecules containing the genotype information were analyzed by matrix-assisted laser desorption ionization time-of-flight using a 3-hydroxypicolinic acid matrix [6].

Associations of NSC82843 with other chemical compounds

Fragmentation of synthetic oligonucleotides under the influence of biotin was investigated using 3-hydroxypicolinic acid (3-HPA) as a matrix-assisted laser desorption/ionization (MALDI) matrix [7].

Gene context of NSC82843

In addition, recent technical advances such as time lag focussing (TLF) and better selection of matrices (such as 3-hydroxypicolinic acid (3 HPA) and picolinic acid (PA)) extended the range of DNA fragments that can be studied by this approach [8].

Analytical, diagnostic and therapeutic context of NSC82843

Matrix-assisted laser desorption with concomitant ionization (MALDI) in conjunction with time-of-flight mass spectrometry (TOF-MS) has been used to analyze underivatized random-base single-stranded DNA (ssDNA) oligomers ranging from 10 to 89 nucleotides in length by embedding them in a solid matrix of 3-hydroxypicolinic acid [9].

References

Chromophore activating enzyme involved in the biosynthesis of the mikamycin B antibiotic etamycin from Streptomyces griseoviridus. Schlumbohm, W., Keller, U. J. Biol. Chem. (1990) [Pubmed]
A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides. Zhou, L., Deng, H., Deng, Q., Zhao, S. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
Ionization mechanism of oligonucleotides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Kong, Y., Zhu, Y., Zhang, J.Y. Rapid Commun. Mass Spectrom. (2001) [Pubmed]
Detection of 500-nucleotide DNA by laser desorption mass spectrometry. Tang, K., Taranenko, N.I., Allman, S.L., Cháng, L.Y., Chen, C.H. Rapid Commun. Mass Spectrom. (1994) [Pubmed]
Matrix-assisted laser desorption/ionization mass spectrometry of restriction enzyme-digested plasmid DNA using an active Nafion substrate. Bai, J., Liu, Y.H., Lubman, D.M., Siemieniak, D. Rapid Commun. Mass Spectrom. (1994) [Pubmed]
Genotyping SNPs using a UV-photocleavable oligonucleotide in MALDI-TOF MS. Vallone, P.M., Fahr, K., Kostrzewa, M. Methods Mol. Biol. (2005) [Pubmed]
Biotin-enhanced fragmentation for direct deoxyribonucleic acid sequencing using matrix-assisted laser desorption/ionization mass spectrometry. Liu, Z., Isola, N.R., Allman, S.L., Chen, C.H. European journal of mass spectrometry (Chichester, England) (2003) [Pubmed]
Approaches to functional genomics: potential of matrix-assisted laser desorption ionization--time of flight mass spectrometry combined with separation methods for the analysis of DNA in biological samples. Lichtenwalter, K.G., Apffel, A., Bai, J., Chakel, J.A., Dai, Y., Hahnenberger, K.M., Li, L., Hancock, W.S. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
Time-of-flight mass spectrometry of underivatized single-stranded DNA oligomers by matrix-assisted laser desorption. Wu, K.J., Shaler, T.A., Becker, C.H. Anal. Chem. (1994) [Pubmed]

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