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Chemical Compound Review:

Hmd-cytosine 4-amino-1-[(2R)-2- (hydroxymethyl)-1,3...

Synonyms: Bch-4556, AC1L2QLO, (-)-BCH 203, 141196-85-2, 2R(-)-cis-Hmd-cytosine, ...

Boivin, A.J. et al., Chou, K.M. et al., Kadhim, S.A. et al., Moore, L.E. et al.

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Disease relevance of Bch-4556

Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models [1].
Troxacitabine (beta-L-Dioxolane-cytidine; Troxatyl) is a beta-L-nucleoside analog, which has shown preclinical antitumor activity in human xenograft tumor models and antileukemic response in patients with relapsed myeloid leukemia [2].

High impact information on Bch-4556

The k(cat) for exonuclease activity on matched, 3' mispaired, and beta-l-dioxolane-cytidine nicked DNA are 2.3, 61.2, and 98.8 min(-1), respectively, and 787.5 min(-1) for APE1 endonuclease [3].
Preclinical pharmacokinetics of beta-L-dioxolane-cytidine, a novel anticancer agent, in rats [4].

References

Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Kadhim, S.A., Bowlin, T.L., Waud, W.R., Angers, E.G., Bibeau, L., DeMuys, J.M., Bednarski, K., Cimpoia, A., Attardo, G. Cancer Res. (1997) [Pubmed]
Action of troxacitabine on cells transduced with human cytidine deaminase cDNA. Boivin, A.J., Gourdeau, H., Momparler, R.L. Cancer Invest. (2004) [Pubmed]
The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G. Chou, K.M., Cheng, Y.C. J. Biol. Chem. (2003) [Pubmed]
Preclinical pharmacokinetics of beta-L-dioxolane-cytidine, a novel anticancer agent, in rats. Moore, L.E., Boudinot, F.D., Chu, C.K. Cancer Chemother. Pharmacol. (1997) [Pubmed]

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