Gene Review:
APEX1 - APEX nuclease (multifunctional DNA repair...
Homo sapiens
Synonyms:
AP endonuclease 1, APE, APE-1, APE1, APEN, ...
- Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. Shen, M., Berndt, S.I., Rothman, N., Mumford, J.L., He, X., Yeager, M., Welch, R., Chanock, S., Keohavong, P., Donahue, M., Zheng, T., Caporaso, N., Lan, Q. Anticancer Res. (2005)
- Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Robertson, K.A., Bullock, H.A., Xu, Y., Tritt, R., Zimmerman, E., Ulbright, T.M., Foster, R.S., Einhorn, L.H., Kelley, M.R. Cancer Res. (2001)
- Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells. Gollapalle, E., Wang, R., Adetolu, R., Tsao, D., Francisco, D., Sigounas, G., Georgakilas, A.G. Radiat. Res. (2007)
- Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Kelley, M.R., Cheng, L., Foster, R., Tritt, R., Jiang, J., Broshears, J., Koch, M. Clin. Cancer Res. (2001)
- Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood. Yeragani, V.K., Pohl, R., Mallavarapu, M., Balon, R. Bipolar disorders. (2003)
- Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Fan, Z., Beresford, P.J., Oh, D.Y., Zhang, D., Lieberman, J. Cell (2003)
- An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA. Chou, K.M., Cheng, Y.C. Nature (2002)
- The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Gros, L., Ishchenko, A.A., Ide, H., Elder, R.H., Saparbaev, M.K. Nucleic. Acids. Res. (2004)
- Alternative nucleotide incision repair pathway for oxidative DNA damage. Ischenko, A.A., Saparbaev, M.K. Nature. (2002)
- Questioning the evidence for Earth's oldest fossils. Brasier, M.D., Green, O.R., Jephcoat, A.P., Kleppe, A.K., Van Kranendonk, M.J., Lindsay, J.F., Steele, A., Grassineau, N.V. Nature (2002)
- DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. Mol, C.D., Izumi, T., Mitra, S., Tainer, J.A. Nature (2000)
- Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Demple, B., Herman, T., Chen, D.S. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site. Shen, J.C., Loeb, L.A. J. Biol. Chem. (2003)
- Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection. Luo, Y., Ji, X., Ling, F., Li, W., Zhang, F., Cao, G., Chen, J. Front. Biosci. (2007)
- Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines. Herring, C.J., Deans, B., Elder, R.H., Rafferty, J.A., MacKinnon, J., Barzilay, G., Hickson, I.D., Hendry, J.H., Margison, G.P. Br. J. Cancer (1999)
- The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. Hofseth, L.J., Khan, M.A., Ambrose, M., Nikolayeva, O., Xu-Welliver, M., Kartalou, M., Hussain, S.P., Roth, R.B., Zhou, X., Mechanic, L.E., Zurer, I., Rotter, V., Samson, L.D., Harris, C.C. J. Clin. Invest. (2003)
- XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. Vidal, A.E., Boiteux, S., Hickson, I.D., Radicella, J.P. EMBO J. (2001)
- Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. Yoshida, A., Urasaki, Y., Waltham, M., Bergman, A.C., Pourquier, P., Rothwell, D.G., Inuzuka, M., Weinstein, J.N., Ueda, T., Appella, E., Hickson, I.D., Pommier, Y. J. Biol. Chem. (2003)
- Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Takao, M., Aburatani, H., Kobayashi, K., Yasui, A. Nucleic Acids Res. (1998)
- Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Fan, Z., Beresford, P.J., Zhang, D., Xu, Z., Novina, C.D., Yoshida, A., Pommier, Y., Lieberman, J. Nat. Immunol. (2003)
- Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product. Masuda, Y., Bennett, R.A., Demple, B. J. Biol. Chem. (1998)
- Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta. Xu, Y.J., Kim, E.Y., Demple, B. J. Biol. Chem. (1998)
- AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. Ranalli, T.A., Tom, S., Bambara, R.A. J. Biol. Chem. (2002)
- Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species. Izumi, T., Hazra, T.K., Boldogh, I., Tomkinson, A.E., Park, M.S., Ikeda, S., Mitra, S. Carcinogenesis (2000)
- APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine. Parsons, J.L., Dianova, I.I., Dianov, G.L. Nucleic Acids Res. (2005)
- Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Hill, J.W., Evans, M.K. Nucleic Acids Res. (2006)
- Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. Kuninger, D.T., Izumi, T., Papaconstantinou, J., Mitra, S. Nucleic Acids Res. (2002)
- A role for p53 in base excision repair. Zhou, J., Ahn, J., Wilson, S.H., Prives, C. EMBO J. (2001)
- Going APE over ref-1. Evans, A.R., Limp-Foster, M., Kelley, M.R. Mutat. Res. (2000)
- Interleukin-8 Induction by Helicobacter pylori in Gastric Epithelial Cells is Dependent on Apurinic/Apyrimidinic Endonuclease-1/Redox Factor-1. O'hara, A.M., Bhattacharyya, A., Mifflin, R.C., Smith, M.F., Ryan, K.A., Scott, K.G., Naganuma, M., Casola, A., Izumi, T., Mitra, S., Ernst, P.B., Crowe, S.E. J. Immunol. (2006)
- Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo. Raffoul, J.J., Banerjee, S., Singh-Gupta, V., Knoll, Z.E., Fite, A., Zhang, H., Abrams, J., Sarkar, F.H., Hillman, G.G. Cancer Res. (2007)
- 3 -5 exonuclease activity of human apurinic/apyrimidinic endonuclease 1 towards DNAs containing dNMP and their modified analogs at the 3 end of single strand DNA break. Dyrkheeva, N.S., Khodyreva, S.N., Sukhanova, M.V., Safronov, I.V., Dezhurov, S.V., Lavrik, O.I. Biochemistry Mosc. (2006)
- Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Szczesny, B., Bhakat, K.K., Mitra, S., Boldogh, I. Mech. Ageing Dev. (2004)
- Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA. Xu, Y.J., DeMott, M.S., Hwang, J.T., Greenberg, M.M., Demple, B. DNA Repair (Amst.) (2003)
- Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway. Daviet, S., Couvé-Privat, S., Gros, L., Shinozuka, K., Ide, H., Saparbaev, M., Ishchenko, A.A. DNA. Repair. (Amst). (2007)
- Regulatory roles of p21 and apurinic/apyrimidinic endonuclease 1 in base excision repair. Tom, S., Ranalli, T.A., Podust, V.N., Bambara, R.A. J. Biol. Chem. (2001)
- Nucleotide sequence and DNA secondary structure, as well as replication protein A, modulate the single-stranded abasic endonuclease activity of APE1. Fan, J., Matsumoto, Y., Wilson, D.M. J. Biol. Chem. (2006)
- Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1. Marsin, S., Vidal, A.E., Sossou, M., Ménissier-de Murcia, J., Le Page, F., Boiteux, S., de Murcia, G., Radicella, J.P. J. Biol. Chem. (2003)
- Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. Marenstein, D.R., Chan, M.K., Altamirano, A., Basu, A.K., Boorstein, R.J., Cunningham, R.P., Teebor, G.W. J. Biol. Chem. (2003)
- Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Dianova, I.I., Bohr, V.A., Dianov, G.L. Biochemistry (2001)
- Expression of the oxidative base excision repair enzymes is not induced in TK6 human lymphoblastoid cells after low doses of ionizing radiation. Inoue, M., Shen, G.P., Chaudhry, M.A., Galick, H., Blaisdell, J.O., Wallace, S.S. Radiat. Res. (2004)
- Transfection of a human gene for the repair of X-ray- and EMS-induced DNA damage. Spiro, I.J., Barrows, L.R., Kennedy, K.A., Ling, C.C. Radiat. Res. (1986)
- Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Ding, S.Z., O'Hara, A.M., Denning, T.L., Dirden-Kramer, B., Mifflin, R.C., Reyes, V.E., Ryan, K.A., Elliott, S.N., Izumi, T., Boldogh, I., Mitra, S., Ernst, P.B., Crowe, S.E. Gastroenterology (2004)
- Two essential but distinct functions of the mammalian abasic endonuclease. Izumi, T., Brown, D.B., Naidu, C.V., Bhakat, K.K., Macinnes, M.A., Saito, H., Chen, D.J., Mitra, S. Proc. Natl. Acad. Sci. U.S.A. (2005)