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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

SF-6,5     5-[6- (diaminomethylideneamino) hexanoylamin...

Synonyms: SF 6,5, AC1L2R1I, 145328-92-3
 
 
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Disease relevance of SF-6,5

  • Daily administration in vivo of SF-6,5 to mice inhibited the formation of B16-F10 colonies in experimental and spontaneous models of metastases [1].
  • RGD-containing peptides and the RGD mimetic, compound SF-6,5, but not the Arg-Gly-Glu (RGE) peptide or the corresponding mimetic, specifically inhibited B16-F10 melanoma cell adhesion to immobilized VN and FN [1].
 

High impact information on SF-6,5

  • Further improvement in liver histology was observed after another 8 weeks of treatment with the analogue SF-6,5 [2].
  • The RGD mimetics, SF-6,5 and NS-11, but not an Arg-Gly-Glu (RGE) mimetic inhibited the adhesion of ocular fibroblasts to immobilized FN [3].
  • SF-6,5 and NS-11 did not inhibit adhesion of the fibroblasts to laminin or spontaneous proliferation of fibroblasts [3].

References

  1. Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics. Hardan, I., Weiss, L., Hershkoviz, R., Greenspoon, N., Alon, R., Cahalon, L., Reich, S., Slavin, S., Lider, O. Int. J. Cancer (1993) [Pubmed]
  2. Inhibition of experimentally-induced liver cirrhosis in rats by a nonpeptidic mimetic of the extracellular matrix-associated Arg-Gly-Asp epitope. Bruck, R., Hershkoviz, R., Lider, O., Aeed, H., Zaidel, L., Matas, Z., Barg, J., Halpern, Z. J. Hepatol. (1996) [Pubmed]
  3. Nonpeptidic analogues of the Arg-Gly-Asp (RGD) sequence specifically inhibit the adhesion of human tenon's capsule fibroblasts to fibronectin. Hershkoviz, R., Melamed, S., Greenspoon, N., Lider, O. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
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