Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

BULLANIN (5S)-3-[(13R)-13-hydroxy-13- [(2R,5R)-5...

Synonyms: CHEMBL145449, SureCN11961385, CHEBI:339942, AC1L2RIU, CTK8E0468, ...

Chang, F.R. et al., Fall, D. et al., Chávez, D. et al., Jolad, S.D. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Desacetyluvaricin

Both Annonaceous acetogenins 1 and 2 showed significant in vitro cytotoxicity toward the human hepatoma cell lines, Hep G2 and 2,2,15, and were compared with the known adjacent bis-tetrahydrofuran acetogenins, neoannonin ( 3). desacetyluvaricin ( 4). bullatacin ( 5). asimicin ( 6). annoglaucin ( 7). squamocin ( 8). and rollimusin ( 9) [1].

High impact information on Desacetyluvaricin

A novel acetogenin, joolanin ( 1), along with eight known acetogenins, squamocin ( 2), desacetyluvaricin ( 3), chamuvarinin ( 4), tripoxyrollin ( 5), diepoxyrollin ( 6), dieporeticanin-1 ( 7), dieporeticanin-2 ( 8) and dieporeticenin ( 9) were isolated from the seeds of UVARIA CHAMAE (Annonaceae) [2].
The cytotoxicity of membranacin (9) and desacetyluvaricin (10) against six human solid tumor cell lines was determined [3].
Desacetyluvaricin from Uvaria accuminata, configuration of uvaricin at C-36 [4].

References

New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata. Chang, F.R., Liaw, C.C., Lin, C.Y., Chou, C.J., Chiu, H.F., Wu, Y.C. Planta Med. (2003) [Pubmed]
A New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenin from the Seeds of Uvaria chamae. Fall, D., Pimentel, L., Champy, P., Gleye, C., Laurens, A., Hocquemiller, R. Planta Med. (2006) [Pubmed]
Tryptamine derived amides and acetogenins from the seeds of Rollinia mucosa. Chávez, D., Acevedo, L.A., Mata, R. J. Nat. Prod. (1999) [Pubmed]
Desacetyluvaricin from Uvaria accuminata, configuration of uvaricin at C-36. Jolad, S.D., Hoffmann, J.J., Cole, J.R., Barry, C.E., Bates, R.B., Linz, G.S., Konig, W.A. J. Nat. Prod. (1985) [Pubmed]

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