Disease relevance of Uvaria

• The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538 [1].

High impact information on Uvaria

• Uvaretin and isouvaretin. Two novel cytotoxic c-benzylflavanones from uvaria chamae L [2].
• Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts [3].
• Tonkinelin: a novel annonaceous acetogenin from Uvaria tonkinensis [4].
• Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae [5].
• A new cytotoxic acetogenin, chamuvarinin (1), containing a tetrahydropyran ring with an adjacent bis-tetrahydrofuran ring, which corresponds to a novel carbon skeleton in this series, was isolated from the roots of Uvaria chamae, together with the previously reported acetogenins squamocin (2), desacetyluvaricin (3), and neoannonin (4) [5].

Associations of Uvaria with chemical compounds

• Klaivanolide, an antiprotozoal lactone from Uvaria klaineana [6].
• 2',3'-Dihydroxy-4',6'-dimethoxchalcone and the corresponding dihydrochalcone were isolated from the leaves of Uvaria dulcis and characterized by chemical and spectral methods [7].
• Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays [8].
• Desacetyluvaricin from Uvaria accuminata, configuration of uvaricin at C-36 [9].
• Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7) [10].

Gene context of Uvaria

• The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity [11].

References