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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Uvaria

  • The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538 [1].

High impact information on Uvaria


Associations of Uvaria with chemical compounds

  • Klaivanolide, an antiprotozoal lactone from Uvaria klaineana [6].
  • 2',3'-Dihydroxy-4',6'-dimethoxchalcone and the corresponding dihydrochalcone were isolated from the leaves of Uvaria dulcis and characterized by chemical and spectral methods [7].
  • Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays [8].
  • Desacetyluvaricin from Uvaria accuminata, configuration of uvaricin at C-36 [9].
  • Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7) [10].

Gene context of Uvaria

  • The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity [11].


  1. Mutagenicity of chamuvaritin: a benzyldihydrochalcone isolated from a medicinal plant. Uwaifo, A.O., Okorie, D.A., Bababunmi, E.A. Cancer Lett. (1979) [Pubmed]
  2. Uvaretin and isouvaretin. Two novel cytotoxic c-benzylflavanones from uvaria chamae L. Hufford, C.D., Lasswell, W.L. J. Org. Chem. (1976) [Pubmed]
  3. Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts. Raynaud, S., Fourneau, C., Laurens, A., Hocquemiller, R., Loiseau, P., Bories, C. Planta Med. (2000) [Pubmed]
  4. Tonkinelin: a novel annonaceous acetogenin from Uvaria tonkinensis. Chen, Y., Yu, D.Q. Planta Med. (1996) [Pubmed]
  5. Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae. Fall, D., Duval, R.A., Gleye, C., Laurens, A., Hocquemiller, R. J. Nat. Prod. (2004) [Pubmed]
  6. Klaivanolide, an antiprotozoal lactone from Uvaria klaineana. Akendengue, B., Roblot, F., Loiseau, P.M., Bories, C., Ngou-Milama, E., Laurens, A., Hocquemiller, R. Phytochemistry (2002) [Pubmed]
  7. A chalcone and a dihydrochalcone from Uvaria dulcis. Chantrapromma, K., Rat-A-pa, Y., Karalai, C., Lojanapiwatana, V., Seechamnanturakit, V. Phytochemistry (2000) [Pubmed]
  8. New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii. Huang, L., Wall, M.E., Wani, M.C., Navarro, H., Santisuk, T., Reutrakul, V., Seo, E.K., Farnsworth, N.R., Kinghorn, A.D. J. Nat. Prod. (1998) [Pubmed]
  9. Desacetyluvaricin from Uvaria accuminata, configuration of uvaricin at C-36. Jolad, S.D., Hoffmann, J.J., Cole, J.R., Barry, C.E., Bates, R.B., Linz, G.S., Konig, W.A. J. Nat. Prod. (1985) [Pubmed]
  10. Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata. Ichimaru, M., Nakatani, N., Takahashi, T., Nishiyama, Y., Moriyasu, M., Kato, A., Mathenge, S.G., Juma, F.D., Nganga, J.N. Chem. Pharm. Bull. (2004) [Pubmed]
  11. The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. Lawrence, N.J., Rennison, D., McGown, A.T., Hadfield, J.A. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
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