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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Annonaceae


Psychiatry related information on Annonaceae


High impact information on Annonaceae


Anatomical context of Annonaceae

  • AIM: To investigate the apoptosis-inducing effect of cheliensisin A (GC-51), a novel styryl-lactone isolated from Goniothalamus cheliensis, on human promyelocytic leukemia HL-60 cells and the mechanism of action involved [10].

Associations of Annonaceae with chemical compounds


Gene context of Annonaceae

  • Bioassay-directed fractionation of an extract prepared from the bark of Goniothalamus andersonii showed that its ingredients, goniothalamin (1) and goniodiol (2) inhibited the cell surface expression of both ICAM-1 and VCAM-1 [16].
  • Composition and antioxidant activity of the essential oils of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark, and fresh and dried fruits, growing in Ghana [17].
  • We extracted and isolated three natural styryl lactones from Goniothalamus griffithii Hook f [18].
  • The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin [19].


  1. Differential hypermelanosis induced by allergic contact dermatitis. Imokawa, G., Kawai, M. J. Invest. Dermatol. (1987) [Pubmed]
  2. New cytotoxic 1-azaanthraquinones and 3-aminonaphthoquinone from the stem bark of Goniothalamus marcanii. Soonthornchareonnon, N., Suwanborirux, K., Bavovada, R., Patarapanich, C., Cassady, J.M. J. Nat. Prod. (1999) [Pubmed]
  3. Phytochemical and antimicrobial properties of constituents of "Ogwu Odenigbo", a popular Nigerian herbal medicine for typhoid fever. Ebi, G.C., Kamalu, T.N. Phytotherapy research : PTR. (2001) [Pubmed]
  4. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. Wheatley, D. J. Psychopharmacol. (Oxford) (2005) [Pubmed]
  5. Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins. Ye, Q., He, K., Oberlies, N.H., Zeng, L., Shi, G., Evert, D., McLaughlin, J.L. J. Med. Chem. (1996) [Pubmed]
  6. Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. Zhao, G.X., Miesbauer, L.R., Smith, D.L., McLaughlin, J.L. J. Med. Chem. (1994) [Pubmed]
  7. Stereoselective synthesis of the naturally occurring styryllactones (+)-goniofufurone and (+)-cardiobutanolide. Ruiz, P., Murga, J., Carda, M., Marco, J.A. J. Org. Chem. (2005) [Pubmed]
  8. Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells. Inayat-Hussain, S.H., Osman, A.B., Din, L.B., Ali, A.M., Snowden, R.T., MacFarlane, M., Cain, K. FEBS Lett. (1999) [Pubmed]
  9. (-)-Discretamine, a selective alpha 1D-adrenoceptor antagonist, isolated from Fissistigma glaucescens. Ko, F.N., Guh, J.H., Yu, S.M., Hou, Y.S., Wu, Y.C., Teng, C.M. Br. J. Pharmacol. (1994) [Pubmed]
  10. Induction of leukemia cell apoptosis by cheliensisin A involves down-regulation of Bcl-2 expression. Zhong, L., Li, C.M., Hao, X.J., Lou, L.G. Acta Pharmacol. Sin. (2005) [Pubmed]
  11. Pharmacological activity of (-)-discretamine, a novel vascular alpha-adrenoceptor and 5-hydroxytryptamine receptor antagonist, isolated from Fissistigma glaucescens. Ko, F.N., Yu, S.M., Su, M.J., Wu, Y.C., Teng, C.M. Br. J. Pharmacol. (1993) [Pubmed]
  12. Uvaretin, a new antitumor agent from Uvaria acuminata (Annonaceae). Cole, J.R., Torrance, S.J., Wiedhopf, R.M., Arora, S.K., Bates, R.B. J. Org. Chem. (1976) [Pubmed]
  13. Genotoxicity of goniothalamin in CHO cell line. Umar-Tsafe, N., Mohamed-Said, M.S., Rosli, R., Din, L.B., Lai, L.C. Mutat. Res. (2004) [Pubmed]
  14. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens. Lin, C.H., Ko, F.N., Wu, Y.C., Lu, S.T., Teng, C.M. Eur. J. Pharmacol. (1993) [Pubmed]
  15. Antiplasmodial activity of Uvaria klaineana. Akendengue, B., Ngou-Milama, E., Roblot, F., Laurens, A., Hocquemiller, R., Grellier, P., Frappier, F. Planta Med. (2002) [Pubmed]
  16. Potential immunosuppressive and antiinflammatory activities of Malaysian medicinal plants characterized by reduced cell surface expression of cell adhesion molecules. Tanaka, S., Yoichi, S., Ao, L., Matumoto, M., Morimoto, K., Akimoto, N., Honda, G., Tabata, M., Oshima, T., Masuda, T., bin Asmawi, M.Z., Ismail, Z., Yusof, S.M., Din, L.B., Said, I.M. Phytotherapy research : PTR. (2001) [Pubmed]
  17. Composition and antioxidant activity of the essential oils of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark, and fresh and dried fruits, growing in Ghana. Karioti, A., Hadjipavlou-Litina, D., Mensah, M.L., Fleischer, T.C., Skaltsa, H. J. Agric. Food Chem. (2004) [Pubmed]
  18. The cytotoxicity of naturally occurring styryl lactones. Tian, Z., Chen, S., Zhang, Y., Huang, M., Shi, L., Huang, F., Fong, C., Yang, M., Xiao, P. Phytomedicine (2006) [Pubmed]
  19. Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica. Diderot, N.T., Silvere, N., Yasin, A., Zareen, S., Fabien, Z., Etienne, T., Choudhary, M.I., Atta-Ur-Rahman, n.u.l.l. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
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