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Chemical Compound Review

AC1Q3WHC     5-dimethylamino-N- [(2R,3R,4S,5R)-3,4,5,6...

Synonyms: CTK8D5410, AR-1E1054, AC1L2SA5, 83047-45-4, Dansylgalactosamine, ...
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High impact information on Dansylgalactosamine

  • The results of stopped flow kinetics with N-dansylgalactosamine and the lectin are consistent with a simple one-step mechanism for which k+1 = 1.33 X 10(4) M-1 s-1 and k-1 = 3.2 X 10(-2) s-1 at 25 degrees C. This k-1 is slower than any reported for a lectin-monosaccharide complex so far [1].
  • This binding is carbohydrate-specific and has an association constant of 1.74 X 10(4) M-1 at 20 degrees C. The lectin has two binding sites for N-dansylgalactosamine [2].
  • The lectin binds to N-dansylgalactosamine, leading to a 15-fold increase in dansyl fluorescence with a concomitant 25-nm blue shift in the emission maximum [1].

Associations of Dansylgalactosamine with other chemical compounds

  • The lectin has two binding sites per molecule for this fluorescent sugar and an association constant of 2.59.10(5) M-1 at 25 degrees C. The binding of N-dansylgalactosamine to the lectin shows that it can accommodate a large hydrophobic substituent on the C-2 carbon of D-galactose [3].

Analytical, diagnostic and therapeutic context of Dansylgalactosamine

  • The sugar-specific binding of N-dansylgalactosamine to WBA II (n = 2; Ka = 5.6 x 10(3) M-1; delta H = -21 kJ.mol-1; delta S = -21.3 J.mol-1.K-1) was utilized in substitution titrations for evaluating the association constants for the interaction of sugars with the lectin [4].


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