Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1L2TQ3 (3S)-3-[[(1S)-1-[[(2S)-2- [[(2S)-2...

Synonyms: U-67827E, U 67827E, 103494-23-1, 105504-60-7 (mono-hydrochloride salt)

Moran, T.H. et al., Schwartz, G.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on U-67827E

U-67827E also inhibited gastric emptying for significantly longer durations than CCK [1].
In rhesus monkeys, U-67827E produced significantly greater inhibitions of daily food intake and did so in a dose-dependent manner with no evidence of compensation or tolerance [1].

Associations of U-67827E with other chemical compounds

To directly test this hypothesis in rats, the effect of the presence of a 5-ml gastric saline load on the ability of a long-acting cholecystokinin analogue U-67827E (0.1-10.0 nmol/kg) to inhibit intake of a 0.5 kcal/ml glucose solution was measured [2].

References

Potent and sustained satiety actions of a cholecystokinin octapeptide analogue. Moran, T.H., Sawyer, T.K., Seeb, D.H., Ameglio, P.J., Lombard, M.A., McHugh, P.R. Am. J. Clin. Nutr. (1992) [Pubmed]
Gastric loads potentiate inhibition of food intake produced by a cholecystokinin analogue. Schwartz, G.J., Netterville, L.A., McHugh, P.R., Moran, T.H. Am. J. Physiol. (1991) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share