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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Eating


Psychiatry related information on Eating


High impact information on Eating

  • In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake [11].
  • An increasing body of evidence supports the concept that opioid and CCK peptides may interact to control food intake, but the evidence is more suggestive than conclusive [12].
  • Of the many factors that influence food intake, there is strong evidence that opioid and CCK peptides, which stimulate feeding and elicit satiety, respectively, are important components that may act in concert to regulate energy balance [12].
  • In several species, most notably the sheep, direct injection into the CSF potently decreases food intake [12].
  • Inhibition of food intake by inhibitors of fatty acid synthase [13].

Chemical compound and disease context of Eating


Biological context of Eating


Anatomical context of Eating


Associations of Eating with chemical compounds

  • Either genetic or biochemical inhibition of hypothalamic CPT1 activity was sufficient to substantially diminish food intake and endogenous glucose production [27].
  • We have been examining one example of this phenomenon, the failure of 6-HDA-lesioned rats to increase food intake when given a systemic injection of 2-deoxy-D-glucose (2-DG) (refs 5, 6) [28].
  • Histamine plays a part in induction of drinking by food intake [29].
  • OEA does not affect food intake when injected into the brain ventricles, and its anorexic actions are prevented when peripheral sensory fibres are removed by treatment with capsaicin [30].
  • Here we show that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide, is a satiety factor and is closely associated with the actions of two important regulators of food intake, leptin and neuropeptide Y [31].

Gene context of Eating


Analytical, diagnostic and therapeutic context of Eating


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