Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Org-7268 [(2S,3S,5S,10S,13S,16S,17S)- 3-hydroxy-10...

Synonyms: KST-1A8174, Org 7268, AR-1A3745, AC1L2Y3V, AC1Q5X7T, ...

Segredo, V. et al., Caldwell, J.E. et al., Wright, P.M. et al., Segredo, V. et al., Wright, P.M. et al.

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Disease relevance of Org-7268

They also had higher plasma concentrations of 3-desacetylvecuronium and a higher frequency of renal failure (seven of seven patients vs. four of nine patients, P less than 0.03) [1].
Also, in cats with liver failure, the duration of action and recovery index of 3-desacetylvecuronium was significantly greater than in control cats (168 +/- 62 vs. 82 +/- 32 min, and 39 +/- 19 vs. 10 +/- 4 min, respectively) [2].

High impact information on Org-7268

Plasma concentrations of vecuronium and 3-desacetylvecuronium were measured by capillary gas chromatography [3].
The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers [4].
Assuming that neuromuscular junction sensitivity was constant, this difference could be explained by considering neuromuscular effects of vecuronium's metabolite, 3-desacetylvecuronium [5].
An intravenous bolus of 300 micrograms.kg-1 of 3-desacetylvecuronium was rapidly injected into the jugular vein [2].

Biological context of Org-7268

The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats [2].

Analytical, diagnostic and therapeutic context of Org-7268

Concentrations of 3-desacetylvecuronium and vecuronium that produced 50% neuromuscular block were 123 (109-154) and 102 (71-123) ng.ml-1, respectively (P < .05) [4].

References

Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo, V., Caldwell, J.E., Matthay, M.A., Sharma, M.L., Gruenke, L.D., Miller, R.D. N. Engl. J. Med. (1992) [Pubmed]
Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats. Segredo, V., Shin, Y.S., Sharma, M.L., Gruenke, L.D., Caldwell, J.E., Khuenl-Brady, K.S., Agoston, S., Miller, R.D. Anesthesiology (1991) [Pubmed]
Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium. Wright, P.M., McCarthy, G., Szenohradszky, J., Sharma, M.L., Caldwell, J.E. Anesthesiology (2004) [Pubmed]
The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers. Caldwell, J.E., Szenohradszky, J., Segredo, V., Wright, P.M., McLoughlin, C., Sharma, M.L., Gruenke, L.D., Fisher, D.M., Miller, R.D. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
Cumulative characteristics of atracurium and vecuronium. A simultaneous clinical and pharmacokinetic study. Wright, P.M., Hart, P., Lau, M., Sharma, M.L., Gruenke, L., Fisher, D.M. Anesthesiology (1994) [Pubmed]

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