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Chemical Compound Review

Org-7268     [(2S,3S,5S,10S,13S,16S,17S)- 3-hydroxy-10...

Synonyms: KST-1A8174, Org 7268, AR-1A3745, AC1L2Y3V, AC1Q5X7T, ...
 
 
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Disease relevance of Org-7268

  • They also had higher plasma concentrations of 3-desacetylvecuronium and a higher frequency of renal failure (seven of seven patients vs. four of nine patients, P less than 0.03) [1].
  • Also, in cats with liver failure, the duration of action and recovery index of 3-desacetylvecuronium was significantly greater than in control cats (168 +/- 62 vs. 82 +/- 32 min, and 39 +/- 19 vs. 10 +/- 4 min, respectively) [2].
 

High impact information on Org-7268

 

Biological context of Org-7268

 

Analytical, diagnostic and therapeutic context of Org-7268

References

  1. Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo, V., Caldwell, J.E., Matthay, M.A., Sharma, M.L., Gruenke, L.D., Miller, R.D. N. Engl. J. Med. (1992) [Pubmed]
  2. Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats. Segredo, V., Shin, Y.S., Sharma, M.L., Gruenke, L.D., Caldwell, J.E., Khuenl-Brady, K.S., Agoston, S., Miller, R.D. Anesthesiology (1991) [Pubmed]
  3. Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium. Wright, P.M., McCarthy, G., Szenohradszky, J., Sharma, M.L., Caldwell, J.E. Anesthesiology (2004) [Pubmed]
  4. The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers. Caldwell, J.E., Szenohradszky, J., Segredo, V., Wright, P.M., McLoughlin, C., Sharma, M.L., Gruenke, L.D., Fisher, D.M., Miller, R.D. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  5. Cumulative characteristics of atracurium and vecuronium. A simultaneous clinical and pharmacokinetic study. Wright, P.M., Hart, P., Lau, M., Sharma, M.L., Gruenke, L., Fisher, D.M. Anesthesiology (1994) [Pubmed]
 
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