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Chemical Compound Review:

TPPO diphenylphosphorylbenzene

Synonyms: PubChem18691, NSC-398, NSC398, ARONIS005287, CHEMBL482091, ...

Esa, A.H. et al., Richoll, S.M. et al., Pavlova, S.V. et al., Emery, R.J. et al., Boeynaems, J.M. et al.

Richoll, Colón,

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Disease relevance of diphenylphosphorylbenzene

Extent of sonochemical degradation and change of toxicity of a pharmaceutical precursor (triphenylphosphine oxide) in water as a function of treatment conditions [1].

High impact information on diphenylphosphorylbenzene

The HPETEs were characterized and assayed by their ability to oxidize triphenylphosphine: triphenylphosphine oxide formation was monitored by gas chromatography [2].
Isotope-labeling experiments ((18)O(2)) established that the oxygen atom incorporated into the triphenylphosphine oxide came from both complex 1 and exogenous dioxygen [3].
At nontoxic concentrations ranging from 0.1 to 20 microM, two of the tested compounds, triphenylphosphine oxide (TPPO) and tetra-o-cresylpiperazinyl diphosphoamidate (TCPD) caused significant suppression of antigen-specific lymphocyte proliferation (P less than 0.01) [4].

Analytical, diagnostic and therapeutic context of diphenylphosphorylbenzene

Determination of triphenylphosphine oxide in active pharmaceutical ingredients by hollow-fiber liquid-phase microextraction followed by reversed-phase liquid chromatography [5].

References

Extent of sonochemical degradation and change of toxicity of a pharmaceutical precursor (triphenylphosphine oxide) in water as a function of treatment conditions. Emery, R.J., Papadaki, M., Freitas Dos Santos, L.M., Mantzavinos, D. Environment international. (2005) [Pubmed]
Preparation and characterization of hydroperoxy-eicosatetraenoic acids (HPETEs). Boeynaems, J.M., Oates, J.A., Hubbard, W.C. Prostaglandins (1980) [Pubmed]
Spectroscopic characterization of the oxo-transfer reaction from a bis(mu-oxo)dicopper(III) complex to triphenylphosphine. Pavlova, S.V., Chen, K.H., Chan, S.I. Dalton transactions (Cambridge, England : 2003) (2004) [Pubmed]
Immunotoxicity of organophosphorus compounds. Modulation of cell-mediated immune responses by inhibition of monocyte accessory functions. Esa, A.H., Warr, G.A., Newcombe, D.S. Clin. Immunol. Immunopathol. (1988) [Pubmed]
Determination of triphenylphosphine oxide in active pharmaceutical ingredients by hollow-fiber liquid-phase microextraction followed by reversed-phase liquid chromatography. Richoll, S.M., Colón, I. Journal of chromatography. A. (2006) [Pubmed]

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