Disease relevance of triphenylphosphane

• The complex trans-[Cu(sacch)(2)(H(2)O)(4)] (2) (produced by thermal dehydration of trans-[Cu(sacch)(2)(H(2)O)(4)].2H(2)O (1)) reacts with triphenylphosphine in CH(2)Cl(2) to produce any or all of three Cu(I) complexes, depending upon conditions [1].
• Phosphine and triphenylphosphine caused mild weight loss during a 10-day exposure period followed by normal rate of weight gain during a 14-day recovery period [2].
• Triphenylphosphine also caused severe weight loss immediately after exposure, followed by normal rate of weight gain [2].
• Other derivatives demonstrated more potent antineoplastic activity against the Ehrlich ascites carcinoma growth including triphenylphosphine cyanoborane, 2-amino-4-methyl-pyridine cyanoborane and 2-amino-pyridine cyanoborane [3].
• Acute and subacute inhalation toxicities of phosphine, phenylphosphine and triphenylphosphine [2].

High impact information on triphenylphosphane

• In intact vesicles, 3- and 4-nitrophenol, diphenylamine, and triphenylphosphine enhanced both the rate of ATP hydrolysis and the amount of Ca2+ accumulated by the vesicles [4].
• A new catalytic cyclization of o-alkynylbenzaldehyde acetals 1 to the functionalized indenes 2 was found to be strictly controlled by the number of triphenylphosphine ligands on the Pd catalyst [5].
• Ligand exchange reactions of 1.5-nm triphenylphosphine-stabilized nanoparticles with omega-functionalized thiols provides a versatile approach to functionalized, 1.5-nm gold nanoparticles from a single precursor [6].
• Unlike 2 a, both gold(III) compounds [Au(C(wedge)N(wedge)C)(PPh3)]+ (3 a) (PPh3 = triphenylphosphine) and [Au2(C(wedge)N(wedge)C)2(mu-dppp)]2+ (3 d) interact only weakly with ctDNA and do not arrest the cell cycle [7].
• Complex 5 immediately reacted with triphenylphosphane sulfide at room temperature to give [[Tm(dtp)(2)](2)(mu-S)] (16), which was characterised by X-ray crystallography, whereas samarium(II) complexes 6 and 7 did not noticeably react with Ph(3)PS over 24 h under the same conditions [8].

Biological context of triphenylphosphane

• When the pre-existing lipid peroxides (LOOH) were removed by incorporating triphenylphosphine into liposomes, Fe(2+) could no longer initiate lipid peroxidation and the acceleration of Fe(2+) oxidation by the liposomes disappeared [9].
• Wittig condensation of 2-acetamido-6-formyl-4-pyrimidinol with the triphenylphosphine ylide 3 derived from N-acetyl-4-(p-carbethoxyanilino)-1-chloro-2-butanone, hydrogenation of the enone intermediate 5, introduction of a 5-amino group via diazonium coupling, and reductive ring closure yielded ethyl N11-acetyl-8-deazahomopteroate (8) [10].
• Kinetics of the oxidation of triphenylphosphine by nitric oxide [11].
• The reactive sites of these complexes in CO substitution reactions have been determined by studying the reactivity of 1 with triphenylphosphine [12].
• Oxygen atom transfer from (mes)(3)Ir=O and dioxygen activation by (mes)(3)Ir can be combined to allow catalytic aerobic oxidations of triphenylphosphine at room temperature and atmospheric pressure with overall activity (approximately 60 turnovers/h) comparable to the fastest reported catalysts [13].

Anatomical context of triphenylphosphane

• The effects of the three hydrophobic molecules triphenylphosphine, trifluoperazine and 3-nitrophenol on Ca2+ uptake and ATPase activity in sarcoplasmic reticulum vesicles was investigated [14].
• Formation of conjugated dienes (CD), the conversion of triphenylphosphine (TPP) to its oxide (TPPO), and the simultaneous production of hydroxy polyunsaturated fatty acids (PUFA-OHs) from these corresponding PUFAs hydroperoxides (PUFA-OOHs) were analyzed in the total lipid extract of ZR cells and of normal human skin fibroblasts (CCD-41Sk:Sk) [15].

Associations of triphenylphosphane with other chemical compounds

• While the value for triphenylarsine sulfide is within 2 kcal/mol of the single experimental estimate, that for triphenylphosphine sulfide is lower by 6 kcal/mol [16].
• The 3-PeDPPO fluorescence intensity of white and dark muscle increased during low-temperature storage (0-24 h) and was clearly correlated with total lipid hydroperoxide levels in muscle extracts, which were determined by using HPLC based on a triphenylphosphine oxidation method (R2 = 0.954) [17].
• Laser photolysis studies of the reaction of chromium(III) octaethylporphyrin complex with triphenylphosphine and triphenylphosphine oxide [18].
• The photophysical properties of Rh(2)(O(2)CCH(3))(4)(L)(2) (L = CH(3)OH, THF = tetrahydrofuran, PPh(3) = triphenylphosphine, py = pyridine) were explored upon excitation with visible light [19].
• 1b and 1c were prepared by condensation of 2',3'-dideoxyuridine (ddU) with the appropriate bis(N-alkylcarbamoyloxymethyl) phosphate in DMA in the presence of triphenylphosphine and diethyl azodicarboxylate (the Mitsunobo reagent) [20].

Gene context of triphenylphosphane

• The oxo complex (mes)(3)Ir=O oxidizes triphenylphosphine to triphenylphosphine oxide in a second-order reaction with DeltaH++ = 10.04 +/- 0.16 kcal/mol and DeltaS++ = -21.6 +/- 0.5 cal/(mol.K) in 1,2-dichloroethane [13].
• Adducts of triphenyl phosphine, triphenyl arsine, and triphenyl stibine with silver(I) bromate have been synthesized and characterized both in solution ((1)H and ESI MS spectroscopy) and in the solid state (IR, single-crystal X-ray structure analysis) [21].
• Measurement of plasma hydroperoxide concentration by FOX-1 assay in conjunction with triphenylphosphine [22].
• Protected glycosyl azides react with acyl chlorides in the presence of triphenylphosphine to afford glycosylamides in high yields, at room temperature [23].
• The other two ligand sites on square planar palladium are occupied by triphenylphosphine (or triphenylarsine) cis to C2' and trans to carbonyl oxygen, and chloride trans to C2' and cis to oxygen [24].

Analytical, diagnostic and therapeutic context of triphenylphosphane

• The special merit of this reaction is that the excess polymer-bound triphenylphosphine and its by-products are easily removed by filtration from the reaction products [25].
• The evolution of hydrogen peroxide by the oxidation reaction was quantitatively followed by reaction with triphenylphosphine (TPP) and high-pressure liquid chromatography determination of the resultant triphenylphosphine oxideformed [26].

References