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Chemical Compound Review:

S-CM-Gtnh2 (2S)-2-[2-[2-[[3-(2- aminoethyl)-1H-indol-5...

Synonyms: CHEMBL159174, CHEBI:365003, AC1L2ZKP, (125I)Gti, 133790-08-6, ...

Boulenguez, P. et al., Boulenguez, P. et al., Boulenguez, P. et al.

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High impact information on S-CM-Gtnh2

Pharmacological characterization of serotonin-O-carboxymethyl-glycyl-tyrosinamide, a new selective indolic ligand for 5-hydroxytryptamine (5-HT)1B and 5-HT1D binding sites [1].
This demonstrates the preferential affinity of S-CM-GTNH2 for 5-HT1B versus 5-HT1A and 5-HT1C binding sites [2].
One of those new ligands, serotonin-O-carboxy-methyl- glycyl-tyrosinamide (S-CM-GTNH2), inhibited 2 nM [3H]5-HT binding to the substantia nigra with an IC50 of 22.4 nM, a value which is 22 times lower than that found in the dentate gyrus and choroid plexus [2].

Analytical, diagnostic and therapeutic context of S-CM-Gtnh2

Moreover, bilateral microinjections of S-CM-GTNH2 into the rat DS tended to potentiate LI, in spite of the increase in DA in n. acc demonstrated here [3].

References

Pharmacological characterization of serotonin-O-carboxymethyl-glycyl-tyrosinamide, a new selective indolic ligand for 5-hydroxytryptamine (5-HT)1B and 5-HT1D binding sites. Boulenguez, P., Chauveau, J., Segu, L., Morel, A., Delaage, M., Lanoir, J. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
A new 5-hydroxy-indole derivative with preferential affinity for 5-HT1B binding sites. Boulenguez, P., Chauveau, J., Segu, L., Morel, A., Lanoir, J., Delaage, M. Eur. J. Pharmacol. (1991) [Pubmed]
Dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5-HT1B agonist into the dorsal subiculum: implications for schizophrenia. Boulenguez, P., Peters, S.L., Mitchell, S.N., Chauveau, J., Gray, J.A., Joseph, M.H. J. Psychopharmacol. (Oxford) (1998) [Pubmed]

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