Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL90488 4-[2- (hydroxymethyl)pyrimidin-4- yl]-N,N...

Synonyms: SureCN7047595, CHEBI:40157, Sdi-2 cpd, CHEBI:248115, Way-135706, ...

Cameron, N.E. et al., Schmidt, R.E. et al.

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Disease relevance of Sdi-2 cpd

Fourteen weeks of treatment with CP-166,572 resulted in a dramatically increased frequency of neuroaxonal dystrophy in ileal mesenteric nerves and SMG [1].

High impact information on Sdi-2 cpd

Thus, despite profound sorbitol dehydrogenase inhibition, WAY-135706 had no beneficial effect on nerve function [2].
Sorbitol was elevated 2.1-32.6-fold by diabetes in lens, retina, kidney, aorta, diaphragm, erythrocytes and sciatic nerve; this was further increased (1.6-8.2-fold) by WAY-135706 whereas WAY-121509 caused a marked reduction [2].

Analytical, diagnostic and therapeutic context of Sdi-2 cpd

To identify the polyol pathway step most relevant to complications, particularly neuropathy, we compared the biochemical effects of a sorbitol dehydrogenase inhibitor, WAY-135706, (250 mg.kg-1.day-1) and an ARI, WAY-121509, (10 mg.kg-1.day-1) on a variety of tissues, and their effects on nerve perfusion and conduction velocity [2].

References

Effect of sorbitol dehydrogenase inhibition on experimental diabetic autonomic neuropathy. Schmidt, R.E., Dorsey, D.A., Beaudet, L.N., Plurad, S.B., Williamson, J.R., Ido, Y. J. Neuropathol. Exp. Neurol. (1998) [Pubmed]
Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. Cameron, N.E., Cotter, M.A., Basso, M., Hohman, T.C. Diabetologia (1997) [Pubmed]

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