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Chemical Compound Review

CHEMBL90488     4-[2- (hydroxymethyl)pyrimidin-4- yl]-N,N...

Synonyms: SureCN7047595, CHEBI:40157, Sdi-2 cpd, CHEBI:248115, Way-135706, ...
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Disease relevance of Sdi-2 cpd


High impact information on Sdi-2 cpd


Analytical, diagnostic and therapeutic context of Sdi-2 cpd

  • To identify the polyol pathway step most relevant to complications, particularly neuropathy, we compared the biochemical effects of a sorbitol dehydrogenase inhibitor, WAY-135706, (250 and an ARI, WAY-121509, (10 on a variety of tissues, and their effects on nerve perfusion and conduction velocity [2].


  1. Effect of sorbitol dehydrogenase inhibition on experimental diabetic autonomic neuropathy. Schmidt, R.E., Dorsey, D.A., Beaudet, L.N., Plurad, S.B., Williamson, J.R., Ido, Y. J. Neuropathol. Exp. Neurol. (1998) [Pubmed]
  2. Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. Cameron, N.E., Cotter, M.A., Basso, M., Hohman, T.C. Diabetologia (1997) [Pubmed]
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