Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN692610 7-[(1R,2S)-2-[4-(1- hydroxyhexyl)phenyl]-5...

Synonyms: AG-D-94051, AH-13205, CTK0H7637, PDSP2_001675, AC1L31NO, ...

Garcia-Villar, R. et al., Woodward, D.F. et al., Milne, S.A. et al., Kobayashi, Y. et al.

Kobayashi, Nakata, Ainai,

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High impact information on AH 13205

The method is utilized in the synthesis of AH-13205, a selective EP2-receptor agonist [1].
Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term [2].
A concentration-related inhibitory response to AH 13205 (IC50 = 3.56 nmol/L, 95% CI 1.28-5.99) was obtained in the baboon [2].
Ocular studies revealed that AH 13205 decreased intraocular pressure in normal and ocular hypertensive monkeys by a mechanism that does not appear to involve inhibition of aqueous humor secretion [3].
Butaprost was less active on these preparations (EEC 42-43) than on classical EP2 receptors, and AH 13205 was much less active (EEC 3100-2780) [4].

References

New reagent system for attaining high regio- and stereoselectivities in allylic displacement of 4-cyclopentene-1,3-diol monoacetate with aryl- and alkenylmagnesium bromides. Kobayashi, Y., Nakata, K., Ainai, T. Org. Lett. (2005) [Pubmed]
Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term. Garcia-Villar, R., Green, L.R., Jenkins, S.L., Wentworth, R.A., Coleman, R.A., Nathanielsz, P.W. J. Soc. Gynecol. Investig. (1995) [Pubmed]
Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor. Woodward, D.F., Bogardus, A.M., Donello, J.E., Fairbairn, C.E., Gil, D.W., Kedzie, K.M., Burke, J.A., Kharlamb, A., Runde, E., Andrews, S.W. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1995) [Pubmed]
Comparison of the EP receptor subtypes mediating relaxation of the rabbit jugular and pig saphenous veins. Milne, S.A., Armstrong, R.A., Woodward, D.F. Prostaglandins (1995) [Pubmed]

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