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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Myometrium


Psychiatry related information on Myometrium


High impact information on Myometrium

  • The hormone relaxin has recently been shown to inhibit not only uterine muscle contraction, but also the release of oxytocin into the plasma [7].
  • At this time high titres of relaxin are present in the plasma and there is evidence that the hormone has a direct inhibitory action on the uterine muscle [8].
  • In vitro, prostaglandin production by the decidua, but not by the myometrium, was increased by the addition of oxytocin [9].
  • Cardiac glycosides that are known to exert estrogen-like effects on classical estrogen target tissues, such as uterine muscle, endometrium, vagina, and mammary gland, probably act on atrial muscle through a genomic, steroid hormone-like mechanism of action [10].
  • We conclude that increased CGRP-Rs in myometrium, and resulting enhanced myometrial sensitivity to CGRP, may play a role in maintaining human myometrium in a quiescent state during pregnancy, and that a decline in the CGRP-Rs at term could contribute to the initiation of labor [11].

Chemical compound and disease context of Myometrium


Biological context of Myometrium


Anatomical context of Myometrium

  • This study clearly demonstrates the expression of HO in the human myometrium and shows that its induction produces CO that limits uterine contractility in pregnant myometrium indicating a role for the HO-CO-cGMP pathway in the maintenance of the quiescent state of the uterus during pregnancy [21].
  • We found that iNOS is expressed in smooth muscle cells of pregnant myometrium [22].
  • In contrast, renin mRNA expression was not detected in basal plate and intertwin chorion (which is separate from decidua), amnion, myometrium, or placental villi [23].
  • In summary, iNOS expression in the myocytes of human myometrium is increased greatly during pregnancy, and declines towards term or with labor [22].
  • PTHrP mRNA was identified by Northern analysis as a single species (approximately 1.8 kilobases) in human amnion, chorion, placenta, decidua, and myometrium [24].

Associations of Myometrium with chemical compounds

  • The progesterone-induced decrease in the number of uterine alpha adrenergic receptors provides a potential explanation for the reduced alpha adrenergic contractile response to epinephrine in the progesterone-primed myometrium [25].
  • SR 49059 showed high affinity for V1a receptors from rat liver (Ki = 1.6 +/- 0.2) and human platelets, adrenals, and myometrium (Ki ranging from 1.1 to 6.3 nM) [26].
  • Prostaglandin E2 receptors (EP) were detected by radioligand binding in nuclear fractions isolated from porcine brain and myometrium [27].
  • Electrophysiological study of the action of angiotensin II on the rat myometrium [28].
  • The accompanying electrophysiological changes were measured on strips of rat myometrium at 35 degrees C using the double sucrose-gap technique [28].

Gene context of Myometrium


Analytical, diagnostic and therapeutic context of Myometrium


  1. Purification and partial sequencing of the major mitogen for human uterine smooth muscle-like cells in leiomyoma extracts. Sourla, A., Koutsilieris, M. J. Clin. Invest. (1995) [Pubmed]
  2. Arterial thrombosis, intrauterine death and "lupus" antiocoagulant: detection of immunoglobulin interfering with prostacyclin formation. Carreras, L.O., Defreyn, G., Machin, S.J., Vermylen, J., Deman, R., Spitz, B., Van Assche, A. Lancet (1981) [Pubmed]
  3. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. Spoelstra, N.S., Manning, N.G., Higashi, Y., Darling, D., Singh, M., Shroyer, K.R., Broaddus, R.R., Horwitz, K.B., Richer, J.K. Cancer Res. (2006) [Pubmed]
  4. Monoclonal antibodies against a component related to soluble estrogen receptor. Coffer, A.I., Lewis, K.M., Brockas, A.J., King, R.J. Cancer Res. (1985) [Pubmed]
  5. Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event. Khac, L.D., Mokhtari, A., Renner, M., Harbon, S. Mol. Pharmacol. (1992) [Pubmed]
  6. Pathophysiology of dysmenorrhea. Akerlund, M. Acta obstetricia et gynecologica Scandinavica. Supplement. (1979) [Pubmed]
  7. Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis. Dayanithi, G., Cazalis, M., Nordmann, J.J. Nature (1987) [Pubmed]
  8. Relaxin affects the central control of oxytocin release. Summerlee, A.J., O'Byrne, K.T., Paisley, A.C., Breeze, M.F., Porter, D.G. Nature (1984) [Pubmed]
  9. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Fuchs, A.R., Fuchs, F., Husslein, P., Soloff, M.S., Fernström, M.J. Science (1982) [Pubmed]
  10. The heart: a target organ for estradiol. Stumpf, W.E., Sar, M., Aumüller, G. Science (1977) [Pubmed]
  11. Involvement of calcitonin gene-related peptide in the modulation of human myometrial contractility during pregnancy. Dong, Y.L., Fang, L., Kondapaka, S., Gangula, P.R., Wimalawansa, S.J., Yallampalli, C. J. Clin. Invest. (1999) [Pubmed]
  12. Increased expression of type I 17beta-hydroxysteroid dehydrogenase enhances in situ production of estradiol in uterine leiomyoma. Kasai, T., Shozu, M., Murakami, K., Segawa, T., Shinohara, K., Nomura, K., Inoue, M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  13. Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. Englund, K., Blanck, A., Gustavsson, I., Lundkvist, U., Sjöblom, P., Norgren, A., Lindblom, B. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  14. The effect of leupeptin on progestin receptors of human uterine tissues. ElDieb, M.R., Andersen, R.N. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  15. Hormonal control of uterine growth: the effect of hypothyroidism on estrogen-stimulated cell division. Kirkland, J.L., Gardner, R.M., Mukku, V.R., Akhtar, M., Stancel, G.M. Endocrinology (1981) [Pubmed]
  16. Endothelin- and oxytocin-induced calcium signaling in cultured human myometrial cells. Maher, E., Bardequez, A., Gardner, J.P., Goldsmith, L., Weiss, G., Mascarina, M., Aviv, A. J. Clin. Invest. (1991) [Pubmed]
  17. Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic. Peruzzi, L., Gianoglio, B., Porcellini, M.G., Coppo, R. Lancet (1999) [Pubmed]
  18. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Wang, W., Van De Water, T., Lufkin, T. Development (1998) [Pubmed]
  19. Regulation of the Ca2+-sensitive domains of the maxi-K channel in the mouse myometrium during gestation. Benkusky, N.A., Fergus, D.J., Zucchero, T.M., England, S.K. J. Biol. Chem. (2000) [Pubmed]
  20. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Condon, J.C., Hardy, D.B., Kovaric, K., Mendelson, C.R. Mol. Endocrinol. (2006) [Pubmed]
  21. Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy. Acevedo, C.H., Ahmed, A. J. Clin. Invest. (1998) [Pubmed]
  22. A decline in myometrial nitric oxide synthase expression is associated with labor and delivery. Bansal, R.K., Goldsmith, P.C., He, Y., Zaloudek, C.J., Ecker, J.L., Riemer, R.K. J. Clin. Invest. (1997) [Pubmed]
  23. Human decidua is a major source of renin. Shaw, K.J., Do, Y.S., Kjos, S., Anderson, P.W., Shinagawa, T., Dubeau, L., Hsueh, W.A. J. Clin. Invest. (1989) [Pubmed]
  24. Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor. Ferguson, J.E., Gorman, J.V., Bruns, D.E., Weir, E.C., Burtis, W.J., Martin, T.J., Bruns, M.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  25. Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. Williams, L.T., Lefkowitz, R.J. J. Clin. Invest. (1977) [Pubmed]
  26. Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors. Serradeil-Le Gal, C., Wagnon, J., Garcia, C., Lacour, C., Guiraudou, P., Christophe, B., Villanova, G., Nisato, D., Maffrand, J.P., Le Fur, G. J. Clin. Invest. (1993) [Pubmed]
  27. Nuclear localization of prostaglandin E2 receptors. Bhattacharya, M., Peri, K.G., Almazan, G., Ribeiro-da-Silva, A., Shichi, H., Durocher, Y., Abramovitz, M., Hou, X., Varma, D.R., Chemtob, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Electrophysiological study of the action of angiotensin II on the rat myometrium. Hamon, G., Worcel, M. Circ. Res. (1979) [Pubmed]
  29. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Aggelidou, E., Hillhouse, E.W., Grammatopoulos, D.K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. Grammatopoulos, D.K., Dai, Y., Randeva, H.S., Levine, M.A., Karteris, E., Easton, A.J., Hillhouse, E.W. Mol. Endocrinol. (1999) [Pubmed]
  31. Urocortin, but not corticotropin-releasing hormone (CRH), activates the mitogen-activated protein kinase signal transduction pathway in human pregnant myometrium: an effect mediated via R1alpha and R2beta CRH receptor subtypes and stimulation of Gq-proteins. Grammatopoulos, D.K., Randeva, H.S., Levine, M.A., Katsanou, E.S., Hillhouse, E.W. Mol. Endocrinol. (2000) [Pubmed]
  32. Expression of cyclooxygenase-2 and prostanoid receptors by human myometrium. Erkinheimo, T.L., Saukkonen, K., Narko, K., Jalkanen, J., Ylikorkala, O., Ristimäki, A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  33. Physiological induction of transient receptor potential canonical proteins, calcium entry channels, in human myometrium: influence of pregnancy, labor, and interleukin-1 beta. Dalrymple, A., Slater, D.M., Poston, L., Tribe, R.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  34. Characteristics of the alpha 2/beta 2-adrenergic receptor-coupled adenylyl cyclase system in rat myometrium during pregnancy. Mhaouty, S., Cohen-Tannoudji, J., Bouet-Alard, R., Limon-Boulez, I., Maltier, J.P., Legrand, C. J. Biol. Chem. (1995) [Pubmed]
  35. Corticotropin-releasing hormone receptor subtype 1 is significantly up-regulated at the time of labor in the human myometrium. Stevens, M.Y., Challis, J.R., Lye, S.J. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  36. Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. Harrison-Woolrych, M.L., Charnock-Jones, D.S., Smith, S.K. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  37. 11 beta-Hydroxysteroid dehydrogenase type II in the human endometrium: localization and activity during the menstrual cycle. Smith, R.E., Salamonsen, L.A., Komesaroff, P.A., Li, K.X., Myles, K.M., Lawrence, M., Krozowski, Z. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
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