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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

European Union

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Disease relevance of European Union


Psychiatry related information on European Union

  • However, one such drug, memantine, was recently approved by the European Union and the US FDA for the treatment of dementia following our group's discovery of its clinically tolerated mechanism of action [6].
  • The first objective of this paper was to report on the psychometric properties of a brief, self-report measure of EI (Brain Resource Inventory for Emotional intelligence Factors or BRIEF), comprising internal emotional capacity (IEC), external emotional capacity (EEC) and self concept (SELF) [7].

High impact information on European Union

  • Here we show that 1- and 2-euro coins induce positive skin-test reactions in sensitized individuals and release 240-320-fold more nickel than is allowed under the European Union Nickel Directive [8].
  • METHODS AND RESULTS--The effect of 17 beta-estradiol pretreatment (100 ng/mL, 72 hours) on cultured sheep EEC PGI2 release in response to multiple physiologically relevant stimuli was studied [9].
  • Mutations in the p63 gene that abolish p63 DNA-binding and transactivation activities cause human diseases, including ectrodactyly ectodermal dysplasia and facial clefting (EEC) syndrome [10].
  • The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients [11].
  • A collaborative study of 9 European Union countries has led to the collection of data on 317 patients who were first seen between 1983 and 1997 and achieved CCgRs with IFN-alpha alone or in combination with hydroxyurea [12].

Chemical compound and disease context of European Union

  • K88 antigen, and important virulence factor in porcine enteropathogenic Escherichia coli (EEC), can be transferred along with the ability to ferment the trisaccharide raffinose (Raf) [13].
  • Although expression of CD14, the best-characterized receptor for LPS to date, was reduced from 93.6% +/- 0.8% in healthy subjects to 50.5% +/- 6.5% in patients with sepsis and was 0.3% in a patient with septic PNH, EEC were found to be unchanged [14].
  • In view of the EURATOM 96/29 [1] regulations, a prospective multicentre study was performed to evaluate the present guidelines given to relatives of patients treated with iodine-131 for both thyroid carcinoma and thyrotoxicosis, based on the real-life radiation burden [15].
  • Vascular wall thickness in hypertension: the Perindopril Regression of Vascular Thickening European Community Trial: PROTECT [16].
  • None of the bottles released bisphenol A at levels that exceed the recently established provisional tolerable daily intake (0.01 mg kg(-1) body weight/day) in the European Union [17].

Biological context of European Union

  • These results demonstrate for the first time the up-regulation of RUNX1/AML1 in EEC correlating with the initial steps of myometrial infiltration [18].
  • Despite the growing threat of major pandemics, the European Union is planning no more than a meager surveillance agency staffed with 70 people on the 2007 horizon: the new European Centre for Disease Control. I argue that an effective structure should be much larger and include a strong research activity [19].
  • The systems were developed for the EURODIAB IDDM Complications Study, part of a European Community funded Concerted Action Programme into the epidemiology and prevention of diabetes (EURODIAB) [20].
  • Herein, we have investigated the complement of IGFBP-1 phosphoisoforms present in extraembryonic coelomic (EEC) fluid, amniotic fluid (AF), and maternal serum (MS) throughout human gestation [21].
  • Levels of IGFBP-3 in MS and EEC did not change significantly with gestational age, whereas an increase in IGFBP-1 was observed in AF after the tenth week of pregnancy [22].

Anatomical context of European Union


Associations of European Union with chemical compounds


Gene context of European Union

  • However, the selective release of IL-1 only when embryos were cocultured with EEC or EEC-conditioned medium indicates an obligatory role of the endometrium in the regulation of the embryonic IL-1 system [29].
  • Finally, the IL-1 profile of a single human embryo cocultured with maternal EEC which successfully implanted and developed is presented, this pattern being similar to that described in the IL-1 producer population [29].
  • The combination of lack of p53 expression, positive PR expression, and loss of PTEN best distinguished between EEC and USC using discriminant analysis (multivariate P = 0.008, <0.001, and 0.05, respectively) [30].
  • Other cytokines, however, did not affect the production of TARC by EEC [31].
  • The increase in levels of TARC in the culture media of EEC paralleled the addition of increasing amounts of IL-4 and IL-13 [31].

Analytical, diagnostic and therapeutic context of European Union


  1. Molecular typing of enteroviruses: current status and future requirements. The European Union Concerted Action on Virus Meningitis and Encephalitis. Muir, P., Kämmerer, U., Korn, K., Mulders, M.N., Pöyry, T., Weissbrich, B., Kandolf, R., Cleator, G.M., van Loon, A.M. Clin. Microbiol. Rev. (1998) [Pubmed]
  2. Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. Wu, W., Slomovitz, B.M., Celestino, J., Chung, L., Thornton, A., Lu, K.H. Cancer Res. (2003) [Pubmed]
  3. X-linked Alport syndrome: natural history in 195 families and genotype- phenotype correlations in males. Jais, J.P., Knebelmann, B., Giatras, I., De Marchi, M., Rizzoni, G., Renieri, A., Weber, M., Gross, O., Netzer, K.O., Flinter, F., Pirson, Y., Verellen, C., Wieslander, J., Persson, U., Tryggvason, K., Martin, P., Hertz, J.M., Schröder, C., Sanak, M., Krejcova, S., Carvalho, M.F., Saus, J., Antignac, C., Smeets, H., Gubler, M.C. J. Am. Soc. Nephrol. (2000) [Pubmed]
  4. Up-regulation of ERM/ETV5 correlates with the degree of myometrial infiltration in endometrioid endometrial carcinoma. Planagumà, J., Abal, M., Gil-Moreno, A., Díaz-Fuertes, M., Monge, M., García, A., Baró, T., Xercavins, J., Reventós, J., Alameda, F. J. Pathol. (2005) [Pubmed]
  5. Temozolomide and treatment of malignant glioma. Friedman, H.S., Kerby, T., Calvert, H. Clin. Cancer Res. (2000) [Pubmed]
  6. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Lipton, S.A. Nature reviews. Drug discovery. (2006) [Pubmed]
  7. Toward an integrated profile of emotional intelligence: introducing a brief measure. Kemp, A.H., Cooper, N.J., Hermens, G., Gordon, E., Bryant, R., Williams, L.M. J. Integr. Neurosci. (2005) [Pubmed]
  8. Metallurgy: high nickel release from 1- and 2-euro coins. Nestle, F.O., Speidel, H., Speidel, M.O. Nature (2002) [Pubmed]
  9. 17 beta-Estradiol inhibits flow- and acute hypoxia-induced prostacyclin release from perfused endocardial endothelial cells. Redmond, E.M., Cherian, M.N., Wetzel, R.C. Circulation (1994) [Pubmed]
  10. DNA-binding and transactivation activities are essential for TAp63 protein degradation. Ying, H., Chang, D.L., Zheng, H., McKeon, F., Xiao, Z.X. Mol. Cell. Biol. (2005) [Pubmed]
  11. The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients. Goerttler, P.S., Steimle, C., März, E., Johansson, P.L., Andreasson, B., Griesshammer, M., Gisslinger, H., Heimpel, H., Pahl, H.L. Blood (2005) [Pubmed]
  12. Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders. Bonifazi, F., de Vivo, A., Rosti, G., Guilhot, F., Guilhot, J., Trabacchi, E., Hehlmann, R., Hochhaus, A., Shepherd, P.C., Steegmann, J.L., Kluin-Nelemans, H.C., Thaler, J., Simonsson, B., Louwagie, A., Reiffers, J., Mahon, F.X., Montefusco, E., Alimena, G., Hasford, J., Richards, S., Saglio, G., Testoni, N., Martinelli, G., Tura, S., Baccarani, M. Blood (2001) [Pubmed]
  13. Characterization of plasmids that encode for the K88 colonization antigen. Shipley, P.L., Gyles, C.L., Falkow, S. Infect. Immun. (1978) [Pubmed]
  14. Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria. Hiki, N., Berger, D., Prigl, C., Boelke, E., Wiedeck, H., Seidelmann, M., Staib, L., Kaminishi, M., Oohara, T., Beger, H.G. Infect. Immun. (1998) [Pubmed]
  15. Real-life radiation burden to relatives of patients treated with iodine-131: a study in eight centres in Flanders (Belgium). Monsieurs, M., Thierens, H., Dierckx, R.A., Casier, K., De Baere, E., De Ridder, L., De Saedeleer, C., De Winter, H., Lippens, M., van Imschoot, S., Wulfrank, D., Simons, M. European journal of nuclear medicine. (1998) [Pubmed]
  16. Vascular wall thickness in hypertension: the Perindopril Regression of Vascular Thickening European Community Trial: PROTECT. Stumpe, K.O., Ludwig, M., Heagerty, A.M., Kolloch, R.E., Mancia, G., Safar, M., Zanchetti, A. Am. J. Cardiol. (1995) [Pubmed]
  17. Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Brede, C., Fjeldal, P., Skjevrak, I., Herikstad, H. Food additives and contaminants. (2003) [Pubmed]
  18. A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma. Planagumà, J., Díaz-Fuertes, M., Gil-Moreno, A., Abal, M., Monge, M., García, A., Baró, T., Thomson, T.M., Xercavins, J., Alameda, F., Reventós, J. Cancer Res. (2004) [Pubmed]
  19. A hard lesson for Europeans: the ASEAN CDC. Tibayrenc, M. Trends Microbiol. (2005) [Pubmed]
  20. Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM complications study. Aldington, S.J., Kohner, E.M., Meuer, S., Klein, R., Sjølie, A.K. Diabetologia (1995) [Pubmed]
  21. Gestational age-dependent expression of insulin-like growth factor-binding protein-1 (IGFBP-1) phosphoisoforms in human extraembryonic cavities, maternal serum, and decidua suggests decidua as the primary source of IGFBP-1 in these fluids during early pregnancy. Martina, N.A., Kim, E., Chitkara, U., Wathen, N.C., Chard, T., Giudice, L.C. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  22. Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy: their potential relevance to maternal-embryonic and fetal interactions. Nonoshita, L.D., Wathen, N.C., Dsupin, B.A., Chard, T., Giudice, L.C. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  23. Bortezomib: proteasome inhibition as an effective anticancer therapy. Richardson, P.G., Mitsiades, C., Hideshima, T., Anderson, K.C. Annu. Rev. Med. (2006) [Pubmed]
  24. Embryonic regulation of integrins beta 3, alpha 4, and alpha 1 in human endometrial epithelial cells in vitro. Simón, C., Gimeno, M.J., Mercader, A., O'Connor, J.E., Remohí, J., Polan, M.L., Pellicer, A. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  25. The effect of interleukin-1 beta (IL-1 beta) on the regulation of IL-1 receptor type I messenger ribonucleic acid and protein levels in cultured human endometrial stromal and glandular cells. Simón, C., Piquette, G.N., Frances, A., el-Danasouri, I., Irwin, J.C., Polan, M.L. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  26. Science and transscience in carcinogen risk assessment--the European Union regulatory process for trichloroethylene. Rudén, C. Journal of toxicology and environmental health. Part B, Critical reviews. (2003) [Pubmed]
  27. Determination of residues of enrofloxacin and its metabolite ciprofloxacin in chicken muscle by capillary electrophoresis using laser-induced fluorescence detection. Horstkötter, C., Jiménez-Lozano, E., Barrón, D., Barbosa, J., Blaschke, G. Electrophoresis (2002) [Pubmed]
  28. Comparative hazards of chrysotile asbestos and its substitutes: A European perspective. Harrison, P.T., Levy, L.S., Patrick, G., Pigott, G.H., Smith, L.L. Environ. Health Perspect. (1999) [Pubmed]
  29. Role of endometrial factors in regulating secretion of components of the immunoreactive human embryonic interleukin-1 system during embryonic development. De los Santos, M.J., Mercader, A., Francés, A., Portolés, E., Remohí, J., Pellicer, A., Simón, C. Biol. Reprod. (1996) [Pubmed]
  30. Serous endometrial cancers that mimic endometrioid adenocarcinomas: a clinicopathologic and immunohistochemical study of a group of problematic cases. Darvishian, F., Hummer, A.J., Thaler, H.T., Bhargava, R., Linkov, I., Asher, M., Soslow, R.A. Am. J. Surg. Pathol. (2004) [Pubmed]
  31. Cultured human endometrial epithelial cells produce thymus and activation-regulated chemokine with stimulation of interleukin-4 and interleukin-13. Nasu, K., Sun, B., Nishida, M., Fukuda, J., Narahara, H., Miyakawa, I. Fertil. Steril. (2004) [Pubmed]
  32. Atopy and nonspecific bronchial responsiveness. A population-based assessment. Spanish Group of the European Community Respiratory Health Survey. Soriano, J.B., Tobías, A., Kogevinas, M., Sunyer, J., Saez, M., Martínez-Moratalla, J., Ramos, J., Maldonado, J.A., Payo, F., Antó, J.M. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  33. The European ST-T database: standard for evaluating systems for the analysis of ST-T changes in ambulatory electrocardiography. Taddei, A., Distante, G., Emdin, M., Pisani, P., Moody, G.B., Zeelenberg, C., Marchesi, C. Eur. Heart J. (1992) [Pubmed]
  34. Stromal-epithelial interactions modulate estrogen responsiveness in normal human endometrium. Pierro, E., Minici, F., Alesiani, O., Miceli, F., Proto, C., Screpanti, I., Mancuso, S., Lanzone, A. Biol. Reprod. (2001) [Pubmed]
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