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Chemical Compound Review

Nicogamol     pyridine-2-carboxylic acid

Synonyms: Nikogamol, picolinate, picolinic acid, PubChem9774, CHEMBL72628, ...
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Disease relevance of alpha-Picolinic acid


High impact information on alpha-Picolinic acid


Chemical compound and disease context of alpha-Picolinic acid


Biological context of alpha-Picolinic acid


Anatomical context of alpha-Picolinic acid


Associations of alpha-Picolinic acid with other chemical compounds


Gene context of alpha-Picolinic acid


Analytical, diagnostic and therapeutic context of alpha-Picolinic acid


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  5. Enhancement of hormonal stimulation in intact cells. Potentiation of GTP-dependent activation of adenylate cyclase. Mukku, V.R., Anderson, W.B., Johnson, G.S. J. Biol. Chem. (1979) [Pubmed]
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  7. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. Melillo, G., Musso, T., Sica, A., Taylor, L.S., Cox, G.W., Varesio, L. J. Exp. Med. (1995) [Pubmed]
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  12. Activity of picolinic acid in combination with the antiprotozoal drug quinacrine against Mycobacterium avium complex. Shimizu, T., Tomioka, H. Antimicrob. Agents Chemother. (2006) [Pubmed]
  13. Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. Rapella, A., Negrioli, A., Melillo, G., Pastorino, S., Varesio, L., Bosco, M.C. Int. J. Cancer (2002) [Pubmed]
  14. Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones. Cai, S., Sato, K., Shimizu, T., Yamabe, S., Hiraki, M., Sano, C., Tomioka, H. J. Antimicrob. Chemother. (2006) [Pubmed]
  15. Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. Stearns, D.M., Wise, J.P., Patierno, S.R., Wetterhahn, K.E. FASEB J. (1995) [Pubmed]
  16. Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. Xiao, H., Kalman, M., Ikehara, K., Zemel, S., Glaser, G., Cashel, M. J. Biol. Chem. (1991) [Pubmed]
  17. IL-4 inhibits the costimulatory activity of IL-2 or picolinic acid but not of lipopolysaccharide on IFN-gamma-treated macrophages. Cox, G.W., Chattopadhyay, U., Oppenheim, J.J., Varesio, L. J. Immunol. (1991) [Pubmed]
  18. Expression of transferrin receptors in phytohemagglutinin-stimulated human T-lymphocytes. Evidence for a three-step model. Pelosi, E., Testa, U., Louache, F., Thomopoulos, P., Salvo, G., Samoggia, P., Peschle, C. J. Biol. Chem. (1986) [Pubmed]
  19. Chromium activates glucose transporter 4 trafficking and enhances insulin-stimulated glucose transport in 3T3-L1 adipocytes via a cholesterol-dependent mechanism. Chen, G., Liu, P., Pattar, G.R., Tackett, L., Bhonagiri, P., Strawbridge, A.B., Elmendorf, J.S. Mol. Endocrinol. (2006) [Pubmed]
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  22. Biosynthesis in vitro of homarine and pyridine carboxylic acids in marine shrimp. Netherton, J.C., Gurin, S. J. Biol. Chem. (1980) [Pubmed]
  23. Proton release during the reductive half-reaction of D-amino acid oxidase. Fitzpatrick, P.F., Massey, V. J. Biol. Chem. (1982) [Pubmed]
  24. Ca2+-mediated activation of phosphoenolpyruvate carboxykinase occurs via release of Fe2+ from rat liver mitochondria. Merryfield, M.L., Lardy, H.A. J. Biol. Chem. (1982) [Pubmed]
  25. Lanthanide complexes of a picolinate ligand derived from 1,4,7-triazacyclononane with potential application in magnetic resonance imaging and time-resolved luminescence imaging. Nonat, A., Gateau, C., Fries, P.H., Mazzanti, M. Chemistry (2006) [Pubmed]
  26. Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells. Alberati-Giani, D., Malherbe, P., Ricciardi-Castagnoli, P., Köhler, C., Denis-Donini, S., Cesura, A.M. J. Immunol. (1997) [Pubmed]
  27. Picolinic acid- or desferrioxamine-inducible autocrine activation of macrophages engineered to produce IFNgamma: an approach for gene therapy. Pastorino, S., Carta, L., Puppo, M., Melillo, G., Bosco, M.C., Varesio, L. Gene Ther. (2004) [Pubmed]
  28. Antagonistic effect of picolinic acid and interferon-gamma on macrophage inflammatory protein-1alpha/beta production. Rapisarda, A., Pastorino, S., Massazza, S., Varesio, L., Bosco, M.C. Cell. Immunol. (2002) [Pubmed]
  29. Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening. Chen, L.L., Li, J., Li, J.Y., Luo, Q.L., Mao, W.F., Shen, Q., Nan, F.J., Ye, Q.Z. Acta Pharmacol. Sin. (2004) [Pubmed]
  30. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Hu, X., Addlagatta, A., Lu, J., Matthews, B.W., Liu, J.O. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  31. Regulation of nitric-oxide synthase mRNA expression by interferon-gamma and picolinic acid. Melillo, G., Cox, G.W., Biragyn, A., Sheffler, L.A., Varesio, L. J. Biol. Chem. (1994) [Pubmed]
  32. Nikkomycin biosynthesis: formation of a 4-electron oxidation product during turnover of NikD with its physiological substrate. Bruckner, R.C., Zhao, G., Venci, D., Jorns, M.S. Biochemistry (2004) [Pubmed]
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