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Chemical Compound Review:

ACMC-1C3UA 3-(1-hydroxyhexyl)oxirane-2- carbaldehyde

Synonyms: AG-D-40654, ACMC-20n6ex, ACMC-20n6fh, AC1L3URE, CTK4B0652, ...

Gonzalez-Reche, L.M. et al., Chen, H.J. et al., Chen, H.J. et al., Chung, F.L. et al.

Chen, Zhang, Cox, Cunningham, Chung,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on 2,3-Epoxy-4-hydroxynonanal

A metabolic pathway critical for detoxification of 2,3-epoxy-4-hydroxynonanal involves the ring-opening by epoxide hydrolase, which abolishes its ability to form cyclic etheno DNA adducts [1].
2,3-epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation [2].
Since occupational exposure to chemicals that may form etheno-adducts can be ruled out, endogenously produced intermediates, such as 2,3-epoxy-4-hydroxynonanal, may be responsible for the formation of etheno-adducts in human DNA [3].

Analytical, diagnostic and therapeutic context of 2,3-Epoxy-4-hydroxynonanal

DNA adducts of 2,3-epoxy-4-hydroxynonanal: detection of 7-(1', 2'-dihydroxyheptyl)-3H-imidazo[2,1-i]purine and 1,N6-ethenoadenine by gas chromatography/negative ion chemical ionization/mass spectrometry [4].

References

2,3-epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase. Chen, H.J., Gonzalez, F.J., Shou, M., Chung, F.L. Carcinogenesis (1998) [Pubmed]
2,3-epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation. Chung, F.L., Chen, H.J., Guttenplan, J.B., Nishikawa, A., Hard, G.C. Carcinogenesis (1993) [Pubmed]
Analysis of ethenoguanine adducts in human urine using high performance liquid chromatography-tandem mass spectrometry. Gonzalez-Reche, L.M., Koch, H.M., Weiss, T., Müller, J., Drexler, H., Angerer, J. Toxicol. Lett. (2002) [Pubmed]
DNA adducts of 2,3-epoxy-4-hydroxynonanal: detection of 7-(1', 2'-dihydroxyheptyl)-3H-imidazo[2,1-i]purine and 1,N6-ethenoadenine by gas chromatography/negative ion chemical ionization/mass spectrometry. Chen, H.J., Zhang, L., Cox, J., Cunningham, J.A., Chung, F.L. Chem. Res. Toxicol. (1998) [Pubmed]

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