Gene Review:
EPHX1 - epoxide hydrolase 1, microsomal (xenobiotic)
Homo sapiens
Synonyms:
EPHX, EPOX, Epoxide hydratase, Epoxide hydrolase 1, HYL1, ...
To-Figueras,
Gené,
Gómez-Catalán,
Piqué,
Borrego,
Corbella,
Shimada,
Gillam,
Oda,
Tsumura,
Sutter,
Guengerich,
Inoue,
Ma,
Umemura,
Mori,
Gong,
Saijo,
Sata,
Kawai,
Kishi,
Korytina,
Yanbaeva,
Babenkova,
Etkina,
Victorova,
Hartsfield,
Sutcliffe,
Everett,
Hassett,
Omiecinski,
Saari,
Habalová,
Salagovic,
Kalina,
Stubna,
Dirksen,
Moghadam,
Mambetova,
Esser,
Fuhrer,
Burdach,
Godderis,
Aka,
Mateuca,
Kirsch-Volders,
Lison,
Veulemans,
Bogaards,
Venekamp,
van Bladeren,
Hartsfield,
Hickman,
Everett,
Shaw,
Lammer,
Finnell,
Haufroid,
Jakubowski,
Janasik,
Ligocka,
Buchet,
Bergamaschi,
Manini,
Mutti,
Ghittori,
Arand,
Hangen,
Oesch,
Hirvonen,
Lison,
- High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers. Jourenkova-Mironova, N., Mitrunen, K., Bouchardy, C., Dayer, P., Benhamou, S., Hirvonen, A. Cancer Res. (2000)
- Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Farin, F.M., Janssen, P., Quigley, S., Abbott, D., Hassett, C., Smith-Weller, T., Franklin, G.M., Swanson, P.D., Longstreth, W.T., Omiecinski, C.J., Checkoway, H. Pharmacogenetics (2001)
- Breast cancer: role of polymorphisms in biotransformation enzymes. Sarmanová, J., Sůsová, S., Gut, I., Mrhalová, M., Kodet, R., Adámek, J., Roth, Z., Soucek, P. Eur. J. Hum. Genet. (2004)
- Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1. To-Figueras, J., Gené, M., Gómez-Catalán, J., Piqué, E., Borrego, N., Corbella, J. Cancer Lett. (2001)
- Association between head and neck cancer and microsomal epoxide hydrolase genotypes. Wenghoefer, M., Pesch, B., Harth, V., Broede, P., Fronhoffs, S., Landt, O., Brüning, T., Abel, J., Bolt, H.M., Herberhold, C., Vetter, H., Ko, Y.D. Arch. Toxicol. (2003)
- Regio- and enantioselectivity of soybean fatty acid epoxide hydrolase. Blée, E., Schuber, F. J. Biol. Chem. (1992)
- Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. Laasanen, J., Romppanen, E.L., Hiltunen, M., Helisalmi, S., Mannermaa, A., Punnonen, K., Heinonen, S. Eur. J. Hum. Genet. (2002)
- Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats. Aitio, A., Aitio, M.L., Camus, A.M., Cardis, E., Bartsch, H. Jpn. J. Cancer Res. (1991)
- Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung. Omiecinski, C.J., Aicher, L., Holubkov, R., Checkoway, H. Pharmacogenetics (1993)
- Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. Liu, M., Sun, A., Shin, E.J., Liu, X., Kim, S.G., Runyons, C.R., Markesbery, W., Kim, H.C., Bing, G. Eur. J. Neurosci. (2006)
- Prenatal prediction of risk of the fetal hydantoin syndrome. Buehler, B.A., Delimont, D., van Waes, M., Finnell, R.H. N. Engl. J. Med. (1990)
- Halothane hepatitis. Detection of a constitutional susceptibility factor. Farrell, G., Prendergast, D., Murray, M. N. Engl. J. Med. (1985)
- Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers. Heckbert, S.R., Weiss, N.S., Hornung, S.K., Eaton, D.L., Motulsky, A.G. J. Natl. Cancer Inst. (1992)
- Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD. Cheng, S.L., Yu, C.J., Chen, C.J., Yang, P.C. Eur. Respir. J. (2004)
- Analysis of the EPHX1 113 polymorphism and GSTM1 homozygous null polymorphism and oral clefting associated with maternal smoking. Hartsfield, J.K., Hickman, T.A., Everett, E.T., Shaw, G.M., Lammer, E.J., Finnell, R.A. Am. J. Med. Genet. (2001)
- The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes. Bogaards, J.J., Venekamp, J.C., van Bladeren, P.J. Chem. Biol. Interact. (1996)
- Microsomal epoxide hydrolase expression as a predictor of tamoxifen response in primary breast cancer: a retrospective exploratory study with long-term follow-up. Fritz, P., Mürdter, T.E., Eichelbaum, M., Siegle, I., Weissert, M., Zanger, U.M. J. Clin. Oncol. (2001)
- An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro. Pirmohamed, M., Kitteringham, N.R., Guenthner, T.M., Breckenridge, A.M., Park, B.K. Biochem. Pharmacol. (1992)
- CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates transcription of the human microsomal epoxide hydrolase gene (EPHX1) through the interaction with DNA-bound NF-Y. Zhu, Q.S., Qian, B., Levy, D. J. Biol. Chem. (2004)
- Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. van der Logt, E.M., Bergevoet, S.M., Roelofs, H.M., Te Morsche, R.H., Dijk, Y., Wobbes, T., Nagengast, F.M., Peters, W.H. Mutat. Res. (2006)
- Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation. Godderis, L., Aka, P., Mateuca, R., Kirsch-Volders, M., Lison, D., Veulemans, H. Toxicology (2006)
- Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. Haufroid, V., Jakubowski, M., Janasik, B., Ligocka, D., Buchet, J.P., Bergamaschi, E., Manini, P., Mutti, A., Ghittori, S., Arand, M., Hangen, N., Oesch, F., Hirvonen, A., Lison, D. Pharmacogenetics (2002)
- Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. Farin, F.M., Bigler, L.G., Oda, D., McDougall, J.K., Omiecinski, C.J. Carcinogenesis (1995)
- Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Krovat, B.C., Tracy, J.H., Omiecinski, C.J. Toxicol. Sci. (2000)
- Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase. Crofton-Sleigh, C., Doherty, A., Ellard, S., Parry, E.M., Venitt, S. Mutagenesis (1993)
- Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes. Zhang, L., Hayes, R.B., Guo, W., McHale, C.M., Yin, S., Wiencke, J.K., Patrick O'Neill, J., Rothman, N., Li, G.L., Smith, M.T. Mutat. Res. (2004)
- Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene. Ma, M., Umemura, T., Mori, Y., Gong, Y., Saijo, Y., Sata, F., Kawai, T., Kishi, R. Toxicol. Lett. (2005)
- Functional analysis of human microsomal epoxide hydrolase genetic variants. Hosagrahara, V.P., Rettie, A.E., Hassett, C., Omiecinski, C.J. Chem. Biol. Interact. (2004)
- Regulation of human microsomal epoxide hydrolase gene (EPHX1) expression by the transcription factor GATA-4. Zhu, Q.S., Qian, B., Levy, D. Biochim. Biophys. Acta (2004)
- Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice. Wang, H., Chanas, B., Ghanayem, B.I. Drug Metab. Dispos. (2002)
- Effects of human soluble epoxide hydrolase polymorphisms on isoprenoid phosphate hydrolysis. Enayetallah, A.E., Grant, D.F. Biochem. Biophys. Res. Commun. (2006)
- Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Shimada, T., Gillam, E.M., Oda, Y., Tsumura, F., Sutter, T.R., Guengerich, F.P., Inoue, K. Chem. Res. Toxicol. (1999)
- Variability in loss of constitutional heterozygosity across loci and among individuals: association with candidate genes in ductal breast carcinoma. Rebbeck, T.R., Godwin, A.K., Buetow, K.H. Mol. Carcinog. (1996)
- Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children. Dirksen, U., Moghadam, K.A., Mambetova, C., Esser, C., Fuhrer, M., Burdach, S. Pediatr. Res. (2004)
- Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children. Korytina, G.F., Yanbaeva, D.G., Babenkova, L.I., Etkina, E.I., Victorova, T.V. J. Mol. Med. (2005)
- Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study. Tranah, G.J., Chan, A.T., Giovannucci, E., Ma, J., Fuchs, C., Hunter, D.J. Mol. Carcinog. (2005)
- Combined analysis of polymorphisms in glutathione S-transferase M1 and microsomal epoxide hydrolase in lung cancer patients. Habalová, V., Salagovic, J., Kalina, I., Stubna, J. Neoplasma (2004)
- Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization. Hartsfield, J.K., Sutcliffe, M.J., Everett, E.T., Hassett, C., Omiecinski, C.J., Saari, J.A. Cytogenet. Cell Genet. (1998)
- Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Zhu, Q.S., Xing, W., Qian, B., von Dippe, P., Shneider, B.L., Fox, V.L., Levy, D. Biochim. Biophys. Acta (2003)