Disease relevance of Occupational Exposure

• Zidovudine after occupational exposure to the human immunodeficiency virus [1].
• We have used data from a survey of nurses in Paris, France, to examine the relation between ectopic pregnancy and various occupational exposures [2].
• Fulminant hepatic failure after occupational exposure to 2-nitropropane [3].
• Liver disease associated with occupational exposure to the solvent dimethylformamide [4].
• A 22-year-old man was initially seen with dermatitis, fever, and seizures after three days of occupational exposure to caprolactam, a nylon fiber precursor [5].

Psychiatry related information on Occupational Exposure

• OBJECTIVES: To study the role of occupational exposures to solvents and aluminium in the aetiology of Alzheimer's disease (AD) [6].
• Interaction of ethanol and xylene with cytochrome P-450 monooxygenases may enhance metabolic capacity of the liver and in consequence modify biological/toxic effects of occupational exposure to solvents in the case of alcohol abuse [7].
• n-Pentane (CAS no. 109-6-0) is a hydrocarbon solvent with an estimated production volume of 50000 metric tons in Europe. The present work was carried out to strengthen the toxicological information available for regulatory decision-making, particularly product classification, occupational exposure limits and risk assessment [8].
• Two hundred and five histologically confirmed cases of nasopharyngeal carcinoma (NPC) in southern China, and an equal number of matched controls, were investigated for their dietary habits, occupational exposure, use of tobacco and alcohol, history of relatives with NPC, and IgA against Epstein-Barr virus (EBV) capsid antigen (IgA/VCA) [9].
• Behavioural effects of occupational exposure to vapour from styrene-based resin were investigated in 10 female workers with a portable test of choice reaction time [10].

High impact information on Occupational Exposure

• OBJECTIVE--To assess the prevalence of latex glove allergy in a population of health care providers (dentists) with a high occupational exposure to latex gloves [11].
• The mortality and incidence of cancer in three groups of workers with occupational exposure to ethylene oxide have been assessed [12].
• The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly known as dioxin, was measured in the adipose tissue of 39 persons with a history of residential, recreational, or occupational exposure in Missouri and in 57 persons in a control group [13].
• Two fatalities after acute occupational exposure to ethylene dibromide [14].
• Occupational exposure to hexachlorocyclopentadiene. How safe is sewage [15]?

Chemical compound and disease context of Occupational Exposure

• In a population-based case-control study, we investigated the potential role of occupational exposure to iron, copper, manganese, mercury, zinc, and lead as risk factors for Parkinson's disease (PD) [16].
• CONCLUSIONS: Occupational exposure to isocyanate vapors and aerosols induces typical hypersensitivity pneumonitis in at least 1% of the isocyanate workers with symptoms [17].
• The risk of meningioma was positively associated with reported occupational exposure to lead, tin, cadmium and ionising radiation in both genders [18].
• Various malignant tumors of the liver, especially liver angiosarcoma, have been described after occupational exposure to vinyl chloride monomer [19].
• Paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and birth outcomes of offspring: birth weight, preterm delivery, and birth defects [20].

Biological context of Occupational Exposure

• In order to investigate the effect of occupational exposure to arsenic in oxidative stress, we measured urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) from 90 semiconductor workers including 50 exposed and 40 nonexposed subjects [21].
• Urinary 1-OHP is a better indicator of occupational exposure to PAH in coke oven workers than 2-naphthol, whereas urinary 2-naphthol may be more sensitive for non-occupational inhalation exposure to PAH [22].
• Energy and protein deficient diets as well as occupational exposure to gasoline did not alter metronidazole pharmacokinetics [23].
• Since this is only the first study on occupational exposures and K-ras mutations in EPC, studies able to refute or to confirm the findings are required before public health implications, if any, are assessed [24].
• We found pronounced ethnic differences in NAT2 genotypes with yet unknown effect on the health risks for environmental or occupational exposures in minority populations [25].

Anatomical context of Occupational Exposure

• The specific cancer types listed above have been implicated in previous studies on occupational exposure to ionizing radiation, except for testis, colon, and melanoma, while the findings on thyroid cancer from previous studies are inconclusive [26].
• The association of occupational exposure to 1,3-butadiene and chromosomal damage in peripheral blood lymphocytes was studied in 40 workers from two production facilities [27].
• The Emergency Department Expert Charting System consistently improved the appropriateness of diagnostic testing and treatment decisions for patients with occupational exposure to blood and body fluids while decreasing median charges [28].
• The influence of occupational exposure to PAHs on the blood plasma levels of p53 and p21WAF1 proteins [29].
• Two surgeons, in whom liver damage developed after occupational exposure to sub-anaesthetic doses of halothane, were found to have a circulating antibody which reacted specifically with halothane-altered hepatocyte membrane components [30].

Associations of Occupational Exposure with chemical compounds

• PURPOSE: The objective of this study was to determine the prevalence and time of appearance of serum anti-p53 antibodies during the pathogenesis of ASL associated with occupational exposure to vinyl chloride [31].
• Increased risks of NHL were also observed among those with occupational exposure to organochlorine insecticides, such as DDT [1.82 (1.04-3.2)] and organic solvents [1.35 (1.06-1.7)], and to other chemicals typically encountered in the agricultural, forestry, or wood products industries [32].
• These data support the conclusion that occupational exposure to o-toluidine is the most likely causal agent of the bladder cancer excess observed among workers in the rubber chemicals department of the plant under study, although exposures to aniline and 4-ABP cannot be ruled out [33].
• Glucose tolerance and occupational exposure to carbon disulphide [34].
• Thus, in a collaborative European study, we assessed the renal effects of occupational exposure to perchloroethylene (PCE) in dry-cleaners compared with matched controls who were simultaneously examined [35].

Gene context of Occupational Exposure

• The effect of GSTM1 null was seen particularly in heavy smokers, and there was a combined effect with occupational exposure of aromatic amines (OR = 2.77, 95% CI = 1.08-7.10) [36].
• We report the relations among ALAD and VDR genotypes, three lead dose measures, and blood pressure and hypertension status in 798 Korean lead workers and 135 controls without occupational exposure to lead [37].
• Further research is ongoing among these workers, which will clarify whether or not electrophoretic GGT tests may be useful in detecting liver function changes due to occupational exposure to PCE [38].
• Among occupational exposures, TCC of patients in contact with stone dust, paints and lacquer, plastics, wood and wood preservers and chemical solvents and adhesives displayed altered partly elevated, partly reduced levels of Rb, p16 and CDK4 mRNA compared to non-exposed subjects [39].
• In the pathogenesis of human bladder cancer due to occupational exposure to "classical" aromatic amines (benzidine, 4-aminodiphenyl, 1-naphthylamine) acetylation by NAT2 is regarded as a detoxication step [40].

Analytical, diagnostic and therapeutic context of Occupational Exposure

• Epidemiological studies have established the carcinogenic risk of occupational exposure to aromatic amines such as benzidine, beta-naphthylamine, and 4-aminobiphenyl [41].
• CONCLUSIONS: Under most reasonable assumptions, chemoprophylaxis with zidovudine, lamivudine, and indinavir following moderate- to high-risk occupational exposures is cost-effective for society [42].
• In this cross-sectional study, we investigated the occurrence of DNA adducts in exfoliated bladder cells of currently exposed, nonsmoking rubber workers (n = 52) and their relationship with occupational exposure estimates and acetylation phenotype (NAT2) [43].
• CONCLUSIONS: These results indicate that even in a hospital with few admissions due to tuberculosis, skin-test conversions associated with occupational exposure may occur (Infect Control Hosp Epidemiol 1996; 17:29-35) [44].
• We have compared occupational exposure to isoflurane and desflurane during cardiopulmonary bypass, with and without a scavenging system at the membrane oxygenator outlet [45].

References