Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

NSC-333308 [5-(2-aminoethanoylamino)- 3,4-dihydroxy...

Synonyms: CTK8G4168, NSC333308, AR-1K7066, NSC 333308, AC1L18LC, ...

Matherly, L.H. et al., Smith, J.M. et al., Nagy, P.L. et al.

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Disease relevance of AIDS-129158

5'-Phosphoribosylglycinamide transformylase (EC 2.1.2.2), encoded by the purN gene of Escherichia coli, catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide (GAR) [1].

High impact information on AIDS-129158

These divergent antifolate sensitivities were not associated with appreciable differences in the levels of dihydrofolate reductase, thymidylate synthase, and 5'-phosphoribosylglycinamide (GAR) transformylase, or the expression of a high affinity membrane folate binding protein receptor in either line [2].
The C-terminal segment of PurU from residues 84 to 280 exhibits 27% identity with 5'-phosphoribosylglycinamide (GAR) transformylase, the product of purN [3].

References

Identification and nucleotide sequence of a gene encoding 5'-phosphoribosylglycinamide transformylase in Escherichia coli K12. Smith, J.M., Daum, H.A. J. Biol. Chem. (1987) [Pubmed]
Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport. Matherly, L.H., Angeles, S.M., McGuire, J.J. Biochem. Pharmacol. (1993) [Pubmed]
purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis. Nagy, P.L., McCorkle, G.M., Zalkin, H. J. Bacteriol. (1993) [Pubmed]

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