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Chemical Compound Review:

Petrin [2-(hydroxymethyl)-3- nitrooxy-2...

Synonyms: PENTRINITROL, Pentrinitrolum, Petrin (TN), CHEMBL466660, LS-102509, ...

Hastings, R.H. et al., Zhang, J. et al., Thum, T. et al., Giles, T.D. et al.

Thum, Fraccarollo, Thum, Schultheiss, Daiber, Wenzel, Munzel, Ertl, Bauersachs,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of W 2197

Effect of sublingual pentrinitrol on exercise tolerance in angina pectoris [1].

High impact information on W 2197

Earlier studies of a site-specific mutant of protein kinase C beta 1 (PKC beta 1) altered at Thr635 and Thr642 indicated that these phosphorylation sites are critical for enzymatic function (Zhang, J., Wang, L., Petrin, J., Bishop, W. R., and Bond, R. W. (1993) Proc. Natl. Acad. Sci. U.S.A. 90,6130-6134) [2].
ISDN, but not PETriN, increased NADPH oxidase-mediated oxidative stress in cultured human EPCs [3].
Parathyroid hormone-related protein (PTHRP) is an autocrine regulator of differentiation for type II pneumocytes [R. H. Hastings, D. Summers-Torres, T. C. Cheung, L. S. Ditmer, D. W. Burton, E. M. Petrin, R. G. Spragg, J. Li, and L. J. Deftos. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L353-L361, 1996] [4].

References

Effect of sublingual pentrinitrol on exercise tolerance in angina pectoris. Giles, T.D., Holder, J.T. Journal of clinical pharmacology. (1978) [Pubmed]
Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation. Zhang, J., Wang, L., Schwartz, J., Bond, R.W., Bishop, W.R. J. Biol. Chem. (1994) [Pubmed]
Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress. Thum, T., Fraccarollo, D., Thum, S., Schultheiss, M., Daiber, A., Wenzel, P., Munzel, T., Ertl, G., Bauersachs, J. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
Parathyroid hormone-related protein, an autocrine growth inhibitor of alveolar type II cells. Hastings, R.H., Summers-Torres, D., Yaszay, B., LeSueur, J., Burton, D.W., Deftos, L.J. Am. J. Physiol. (1997) [Pubmed]

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