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Chemical Compound Review

Petrin     [2-(hydroxymethyl)-3- nitrooxy-2...

Synonyms: PENTRINITROL, Pentrinitrolum, Petrin (TN), CHEMBL466660, LS-102509, ...
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Disease relevance of W 2197


High impact information on W 2197

  • Earlier studies of a site-specific mutant of protein kinase C beta 1 (PKC beta 1) altered at Thr635 and Thr642 indicated that these phosphorylation sites are critical for enzymatic function (Zhang, J., Wang, L., Petrin, J., Bishop, W. R., and Bond, R. W. (1993) Proc. Natl. Acad. Sci. U.S.A. 90,6130-6134) [2].
  • ISDN, but not PETriN, increased NADPH oxidase-mediated oxidative stress in cultured human EPCs [3].
  • Parathyroid hormone-related protein (PTHRP) is an autocrine regulator of differentiation for type II pneumocytes [R. H. Hastings, D. Summers-Torres, T. C. Cheung, L. S. Ditmer, D. W. Burton, E. M. Petrin, R. G. Spragg, J. Li, and L. J. Deftos. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L353-L361, 1996] [4].


  1. Effect of sublingual pentrinitrol on exercise tolerance in angina pectoris. Giles, T.D., Holder, J.T. Journal of clinical pharmacology. (1978) [Pubmed]
  2. Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation. Zhang, J., Wang, L., Schwartz, J., Bond, R.W., Bishop, W.R. J. Biol. Chem. (1994) [Pubmed]
  3. Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress. Thum, T., Fraccarollo, D., Thum, S., Schultheiss, M., Daiber, A., Wenzel, P., Munzel, T., Ertl, G., Bauersachs, J. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  4. Parathyroid hormone-related protein, an autocrine growth inhibitor of alveolar type II cells. Hastings, R.H., Summers-Torres, D., Yaszay, B., LeSueur, J., Burton, D.W., Deftos, L.J. Am. J. Physiol. (1997) [Pubmed]
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