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Chemical Compound Review

BENZYL VIOLET     sodium3-[[[4-[(4- dimethylazaniumylidene-1...

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High impact information on [4-[bis[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]methylene]-1-cyclohexa-2,5-dienylidene]-dimethyl-ammonium

  • Using a new vital dye, acid violet 49, as a stain, a series of possible coatings including albumin and hyaluronic acid was evaluated in vitro and in vivo [1].
  • The levels of the colour distributed in the liver, kidney abdominal muscle and blood serum were in the range of 1--3 microgram/g of tissue in rats fed a diet containing 5% Benzyl Violet 4B for 8 weeks, whereas they were slightly lower in rats fed the diet for 18 weeks [2].
  • Fresh allogeneic nonadherent peripheral blood mononuclear cells were incubated with the corneal-cell populations and assayed for lymphocyte binding and target-cell cytotoxicity by acid-violet-49 vital staining [3].
  • The vital dye, acid violet 49, was applied to evaluate endothelial cell function and damage [4].


  1. A new and effective protective agent for intraocular lens insertion. Harrison, S.E., Soll, D.B., Shayegan, M., Clinch, T. Ophthalmology (1982) [Pubmed]
  2. Metabolism of triphenylmethane colours II. Absorption, excretion and distribution of Benzyl Violet 4B (FD and C Violet No. 1) in rats. Minegishi, K.I., Yamaha, T. Toxicology (1977) [Pubmed]
  3. In vitro demonstration of human natural killing of keratocytes and corneal epithelium. Opremcak, E.M., Whisler, R.L., Dangel, M.E. Annals of ophthalmology. (1989) [Pubmed]
  4. Evaluation and protection of corneal endothelium. Soll, D.B., Harrison, S.E., Arturi, F.C., Clinch, T. Journal - American Intra-Ocular Implant Society. (1980) [Pubmed]
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