The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Serum


Psychiatry related information on Serum


High impact information on Serum

  • PDGF is a connective tissue mitogen that has been associated with clotted blood serum for at least 300 million years [11].
  • Acetylcholine concentrations in whole rat brain or in various brain regions and free choline concentrations in blood serum and brain vary with dietary choline consumption [12].
  • In patients with vomiting, diarrhea, or decreased oral intake, few findings have proven utility, and clinicians should measure serum electrolytes, serum blood urea nitrogen, and creatinine levels when diagnostic certainty is required [13].
  • Normal marrow plasma and peripheral blood serum had no or very low levels of IL-6 [14].
  • We measured the blood serum levels of polychlorinated dibenzo-p-dioxins and dibenzofurans, which were substituted with chlorine at the 2,3,7,8 position, in the nine pesticide applicators and in a matched group of nine control subjects [15].

Chemical compound and disease context of Serum


Biological context of Serum


Anatomical context of Serum


Associations of Serum with chemical compounds


Gene context of Serum

  • TFPI secreted into the media containing whole blood serum was consistently higher (approximately 1.5-fold at 8 hours) than that secreted into the media supplemented with serum obtained from plasma lacking the formed elements; these cells also expressed similarly increased levels of TFPI mRNA [35].
  • FGF-2 or phorbol ester treatment can also increase FR-1 mRNA levels; in contrast, whole blood serum or individual growth factors present in serum have only minimal effects on FR-1 mRNA expression [36].
  • To further investigate the hormone-like characteristics of PLF, we have determined the site of PLF synthesis and storage in the placenta and its concentration in blood serum during pregnancy [37].
  • Markedly elevated levels of IL-6 and IL-8 were detected in iliac BMS, and much lower levels were found in tibial bone marrow and peripheral blood serum [38].
  • A significant increase in IL-15 serum blood levels was also observed in acute VL patients compared with healed ones [39].

Analytical, diagnostic and therapeutic context of Serum


  1. Skeletal muscle glucose transporter gene expression is not affected by injecting growth-hormone-secreting cells in young rats. Imamura, H., Morimoto, I., Etoh, S., Usa, T., Namba, H., Ohtsuru, A., Yokota, A., Nagataki, S., Yamashita, S. Diabetologia (1993) [Pubmed]
  2. The use of adenoviral vectors for gene therapy and gene transfer in vivo. Bramson, J.L., Graham, F.L., Gauldie, J. Curr. Opin. Biotechnol. (1995) [Pubmed]
  3. Effects of aspirin or basic amino acids on collagen cross-links and complications in NIDDM. Contreras, I., Reiser, K.M., Martinez, N., Giansante, E., Lopez, T., Suarez, N., Postalian, S., Molina, M., Gonzalez, F., Sanchez, M.R., Camejo, M., Blanco, M.C. Diabetes Care (1997) [Pubmed]
  4. Oversimplification of diet: coronary heart disease relationships and exaggerated diet recommendations. Reiser, R. Am. J. Clin. Nutr. (1978) [Pubmed]
  5. Monitoring of brain spiking activity and autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptors in blood serum of rats with cobalt-induced epilepsy. Dambinova, S.A., Granstrem, O.K., Tourov, A., Salluzzo, R., Castello, F., Izykenova, G.A. J. Neurochem. (1998) [Pubmed]
  6. Cognitive and motor-sensory performances in toxic and nontoxic epileptic subjects. Matthews, C.G., Harley, J.P. Neurology (1975) [Pubmed]
  7. A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917. Grozdanov, L., Zähringer, U., Blum-Oehler, G., Brade, L., Henne, A., Knirel, Y.A., Schombel, U., Schulze, J., Sonnenborn, U., Gottschalk, G., Hacker, J., Rietschel, E.T., Dobrindt, U. J. Bacteriol. (2002) [Pubmed]
  8. Bioaccumulation and locomotor effects of manganese sulfate in Sprague-Dawley rats following subchronic (90 days) inhalation exposure. Tapin, D., Kennedy, G., Lambert, J., Zayed, J. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  9. Cerebrospinal fluid proteomics and human immunodeficiency virus dementia: preliminary observations. Berger, J.R., Avison, M., Mootoor, Y., Beach, C. J. Neurovirol. (2005) [Pubmed]
  10. Renal abscess: early diagnosis and treatment. Yen, D.H., Hu, S.C., Tsai, J., Kao, W.F., Chern, C.H., Wang, L.M., Lee, C.H. The American journal of emergency medicine. (1999) [Pubmed]
  11. The molecular biology of platelet-derived growth factor. Stiles, C.D. Cell (1983) [Pubmed]
  12. Brain acetylcholine: control by dietary choline. Cohen, E.L., Wurtman, R.J. Science (1976) [Pubmed]
  13. The rational clinical examination. Is this patient hypovolemic? McGee, S., Abernethy, W.B., Simel, D.L. JAMA (1999) [Pubmed]
  14. Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. Roodman, G.D., Kurihara, N., Ohsaki, Y., Kukita, A., Hosking, D., Demulder, A., Smith, J.F., Singer, F.R. J. Clin. Invest. (1992) [Pubmed]
  15. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses. Smith, A.H., Patterson, D.G., Warner, M.L., MacKenzie, R., Needham, L.L. J. Natl. Cancer Inst. (1992) [Pubmed]
  16. Lymphadenopathy, elevated serum IgE levels, autoimmunity, and mast cell accumulation in flaky skin mutant mice. Pelsue, S.C., Schweitzer, P.A., Schweitzer, I.B., Christianson, S.W., Gott, B., Sundberg, J.P., Beamer, W.G., Shultz, L.D. Eur. J. Immunol. (1998) [Pubmed]
  17. Level of nitric oxide-dependent cGMP in patients with migraine. Stepien, A., Chalimoniuk, M. Cephalalgia : an international journal of headache. (1998) [Pubmed]
  18. Ovaries and adrenals in murine Schistosomiasis mansoni. III. Morphology and function of the adrenals in acute infection. Tiboldi, T., De Semet, M., Colfs, B., Van Soom, H. Am. J. Trop. Med. Hyg. (1979) [Pubmed]
  19. Hypothyroidism changes adenine nucleotide hydrolysis in synaptosomes from hippocampus and cerebral cortex of rats in different phases of development. Bruno, A.N., Ricachenevsky, F.K., Pochmann, D., Bonan, C.D., Battastini, A.M., Barreto-Chaves, M.L., Sarkis, J.J. Int. J. Dev. Neurosci. (2005) [Pubmed]
  20. The major 20-kDa polysaccharide of Staphylococcus epidermidis extracellular slime and its antibodies as powerful agents for detecting antibodies in blood serum and differentiating among slime-positive and -negative S. epidermidis and other staphylococci species. Karamanos, N.K., Syrokou, A., Panagiotopoulou, H.S., Anastassiou, E.D., Dimitracopoulos, G. Arch. Biochem. Biophys. (1997) [Pubmed]
  21. Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes. Guo, Z., Liliom, K., Fischer, D.J., Bathurst, I.C., Tomei, L.D., Kiefer, M.C., Tigyi, G. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  22. Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis. English, D., Welch, Z., Kovala, A.T., Harvey, K., Volpert, O.V., Brindley, D.N., Garcia, J.G. FASEB J. (2000) [Pubmed]
  23. In vivo generation of hydrogen peroxide in the rat corpus luteum during luteolysis. Riley, J.C., Behrman, H.R. Endocrinology (1991) [Pubmed]
  24. Simultaneous determination of bromide and iodide as acetone derivatives by gas chromatography and electron capture detection in natural waters and biological fluids. Maros, L., Káldy, M., Igaz, S. Anal. Chem. (1989) [Pubmed]
  25. Chemiluminescent image detection of haptoglobin phenotyping after polyacrylamide gel electrophoresis. Huang, G., Ouyang, J., Delanghe, J.R., Baeyens, W.R., Dai, Z. Anal. Chem. (2004) [Pubmed]
  26. Platelet-derived growth factor promotes proliferation of erythropoietic progenitor cells in vitro. Dainiak, N., Davies, G., Kalmanti, M., Lawler, J., Kulkarni, V. J. Clin. Invest. (1983) [Pubmed]
  27. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. Desmoulière, A., Geinoz, A., Gabbiani, F., Gabbiani, G. J. Cell Biol. (1993) [Pubmed]
  28. Selenium and other elements in human maternal and umbilical serum, as determined simultaneously by proton-induced X-ray emission. Hyvönen-Dabek, M., Nikkinen-Vilkki, P., Dabek, J.T. Clin. Chem. (1984) [Pubmed]
  29. Effects of inhaled fluticasone and oral prednisolone on clinical and inflammatory parameters in patients with asthma. Meijer, R.J., Kerstjens, H.A., Arends, L.R., Kauffman, H.F., Koëter, G.H., Postma, D.S. Thorax (1999) [Pubmed]
  30. Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation. Murphy-Ullrich, J.E., Mosher, D.F. J. Cell Biol. (1987) [Pubmed]
  31. Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid. Zhang, Q., Checovich, W.J., Peters, D.M., Albrecht, R.M., Mosher, D.F. J. Cell Biol. (1994) [Pubmed]
  32. Cardiac transplantation: improved quality of survival with a modified immunosuppressive protocol. Trento, A., Griffith, B.P., Hardesty, R.L., Kormos, R.L., Thompson, M.E., Bahnson, H.T. Circulation (1987) [Pubmed]
  33. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Morley, J.E., Kaiser, F., Raum, W.J., Perry, H.M., Flood, J.F., Jensen, J., Silver, A.J., Roberts, E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  34. Blood serum atherogenicity associated with coronary atherosclerosis. Evidence for nonlipid factor providing atherogenicity of low-density lipoproteins and an approach to its elimination. Orekhov, A.N., Tertov, V.V., Pokrovsky, S.N., Adamova IYu, n.u.l.l., Martsenyuk, O.N., Lyakishev, A.A., Smirnov, V.N. Circ. Res. (1988) [Pubmed]
  35. Expression of tissue factor pathway inhibitor by cultured endothelial cells in response to inflammatory mediators. Ameri, A., Kuppuswamy, M.N., Basu, S., Bajaj, S.P. Blood (1992) [Pubmed]
  36. A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase. Donohue, P.J., Alberts, G.F., Hampton, B.S., Winkles, J.A. J. Biol. Chem. (1994) [Pubmed]
  37. Trophoblastic giant cells of the mouse placenta as the site of proliferin synthesis. Lee, S.J., Talamantes, F., Wilder, E., Linzer, D.I., Nathans, D. Endocrinology (1988) [Pubmed]
  38. Remarkable elevation of interleukin 6 and interleukin 8 levels in the bone marrow serum of patients with rheumatoid arthritis. Tanabe, M., Ochi, T., Tomita, T., Suzuki, R., Sakata, T., Shimaoka, Y., Nakagawa, S., Ono, K. J. Rheumatol. (1994) [Pubmed]
  39. IL-15 in human visceral leishmaniasis caused by Leishmania infantum. Milano, S., Di Bella, G., D'Agostino, P., Barbera, C., Caruso, R., La Rosa, M., Ferlazzo, V., Vitale, G., La Russa, C., Gambino, G., Chifari, N., Mansueto, S., Cillari, E. Clin. Exp. Immunol. (2002) [Pubmed]
  40. Platelet-derived growth factor in vivo: levels, activity, and rate of clearance. Bowen-Pope, D.F., Malpass, T.W., Foster, D.M., Ross, R. Blood (1984) [Pubmed]
  41. Guamanian neurodegenerative disease: investigation of the calcium metabolism/heavy metal hypothesis. Ahlskog, J.E., Waring, S.C., Kurland, L.T., Petersen, R.C., Moyer, T.P., Harmsen, W.S., Maraganore, D.M., O'Brien, P.C., Esteban-Santillan, C., Bush, V. Neurology (1995) [Pubmed]
  42. Serum lipids and lipoprotein(a) concentrations in Chinese NIDDM patients. Relation to metabolic control. Chang, C.J., Kao, J.T., Wu, T.J., Lu, F.H., Tai, T.Y. Diabetes Care (1995) [Pubmed]
  43. Increased levels of the soluble adhesion molecule E-selectin in essential hypertension. Blann, A.D., Tse, W., Maxwell, S.J., Waite, M.A. J. Hypertens. (1994) [Pubmed]
  44. Evaluation of diabetic ketoacidosis-related ionic metabolites in human blood serum by capillary electrophoresis. Jager, A.V., Tavares, M.F. Electrophoresis (2003) [Pubmed]
WikiGenes - Universities