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Chemical Compound Review

Sensipar     N-[(1R)-1-naphthalen-1- ylethyl]-3-[3...

Synonyms: Mimpara, Parareg, Regpara, CNC-HCl, Cinacalcet HCl, ...
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High impact information on AMG 073


Anatomical context of AMG 073

  • A novel therapeutic, cinacalcet HCl (formerly AMG 073; Sensipar in the US and Mimpara in Europe; Amgen, Inc.), binds directly to the calcium-sensing receptor (CaR) on the cells of the parathyroid gland, increasing the receptor's sensitivity to calcium and reducing PTH, serum calcium and phosphorus levels [5].


  1. No effect of renal function or dialysis on pharmacokinetics of cinacalcet (Sensipar/Mimpara). Padhi, D., Harris, R.Z., Salfi, M., Sullivan, J.T. Clinical pharmacokinetics. (2005) [Pubmed]
  2. How do calcimimetics fit into the management of parathyroid hormone, calcium, and phosphate disturbances in dialysis patients? Shahapuni, I., Mansour, J., Harbouche, L., Maouad, B., Benyahia, M., Rahmouni, K., Oprisiu, R., Bonne, J.F., Monge, M., El Esper, N., Presne, C., Moriniere, P., Choukroun, G., Fournier, A. Seminars in dialysis. (2005) [Pubmed]
  3. Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients. Strippoli, G.F., Tong, A., Palmer, S.C., Elder, G., Craig, J.C. Cochrane database of systematic reviews (Online) (2006) [Pubmed]
  4. Cinacalcet hydrochloride (Sensipar). Poon, G. Proceedings (Baylor University. Medical Center) (2005) [Pubmed]
  5. Cinacalcet HCl: a novel therapeutic for hyperparathyroidism. de Francisco, A.L. Expert opinion on pharmacotherapy. (2005) [Pubmed]
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