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Chemical Compound Review:

PubChem15330 1-methyl-4-(4- methylphenyl)sulfinyl-benzene

Synonyms: SureCN235851, T42803_ALDRICH, ACMC-209ecs, ANW-22874, NSC-73128, ...

Rettie, A.E. et al., Hanlon, S.P. et al.

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Disease relevance of NSC 73128

Purified dimethyl sulfoxide reductase from Rhodobacter capsulatus catalysed the selective removal of (S)-methyl p-tolyl sulfoxide from a racemic mixture of methyl p-tolyl sulfoxide and resulted in an 88% recovery of enantiomerically pure (R)-methyl p-tolyl sulfoxide [1].

High impact information on NSC 73128

The enantiomeric purity of the (R)-methyl p-tolyl sulfoxide metabolite, generated by detergent-solubilized rabbit liver microsomes, decreased progressively with increasing substrate concentration, from a high of 96% enantiomeric excess at a substrate concentration of 5 microM to a low of 63% enantiomeric excess at a substrate concentration of 2 mM [2].

References

Asymmetric reduction of racemic sulfoxides by dimethyl sulfoxide reductases from Rhodobacter capsulatus, Escherichia coli and Proteus species. Hanlon, S.P., Graham, D.L., Hogan, P.J., Holt, R.A., Reeve, C.D., Shaw, A.L., McEwan, A.G. Microbiology (Reading, Engl.) (1998) [Pubmed]
Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3, and FMO5 expressed in Escherichia coli. Rettie, A.E., Lawton, M.P., Sadeque, A.J., Meier, G.P., Philpot, R.M. Arch. Biochem. Biophys. (1994) [Pubmed]

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