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Chemical Compound Review

ETHANE     ethane

Synonyms: Bimethyl, Dimethyl, Ethan, Venoterpine, Methylmethane, ...
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Disease relevance of ethane


Psychiatry related information on ethane


High impact information on ethane

  • DNA footprint analysis with dimethyl sulfate demonstrated that the 7-mer region of the RSS was strongly protected when complexed with the binding protein [11].
  • The binding of DNA to gyrase confers no protection against alkylation of the DNA by dimethyl sulfate [12].
  • Increased iron supply led to elevated phytoplankton biomass and rates of photosynthesis in surface waters, causing a large drawdown of carbon dioxide and macronutrients, and elevated dimethyl sulphide levels after 13 days [13].
  • These are variably spaced depending on the genes. tau, a large transcription factor purified from yeast cells, interacts with these two control elements as shown by DNase I footprinting, exonuclease digestion, dimethyl sulphate protection experiments and by analysis of point mutations [14].
  • We use this approach to study the binding of regulatory proteins to the lac operon in vivo and detect changes in the reactivity (inhibition or enhancement) of guanines to methylation by dimethyl sulphate caused by the proximity of proteins to the N-7 atom of these guanines [15].

Chemical compound and disease context of ethane


Biological context of ethane


Anatomical context of ethane

  • Relative to reactions on naked DNA, there are changes (protections and enhancements) in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage [23].
  • When HL60 cells were exposed to dimethyl sulfoxide, transferrin receptor display decreased, and 42/6 growth inhibition was abrogated or greatly diminished [25].
  • In contrast, HL-60, which differentiates toward cells of the monocyte lineage in response to phorbol 12-myristate 13-acetate (based on the above criteria), and toward granulocytes in response to dimethyl sulfoxide, did not differentiate when cultured with alpha- or beta-IFN [26].
  • Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide [27].
  • Under similar conditions, the potent carcinogen 7,12-dimethylbenz(alpha)athracene almost completely destroyed the sebaceous glands at a dose of 0.05 mg/mouse, but dimethyl sulfoxide (used as solvent for the test compounds) had no effect [28].

Associations of ethane with other chemical compounds


Gene context of ethane

  • Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant [33].
  • Dimethyl PGE2 reversed the effect of DSS on COX-1 expression [34].
  • Loss of SUVH1 and SUVH4 causes weak reduction of heterochromatic histone H3K9 dimethylation, whereas in SUVH2 null plants mono- and dimethyl H3K9, mono- and dimethyl H3K27, and monomethyl H4K20, the histone methylation marks of Arabidopsis heterochromatin are significantly reduced [35].
  • Footprinting of the RAG1-RAG2 complex with 1, 10-phenanthroline-copper and dimethyl sulfate protection reveal that both the heptamer and the nonamer are involved [36].
  • The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila [37].

Analytical, diagnostic and therapeutic context of ethane


  1. Specific DNA binding of GAL4, a positive regulatory protein of yeast. Giniger, E., Varnum, S.M., Ptashne, M. Cell (1985) [Pubmed]
  2. Substituting an alpha-helix switches the sequence-specific DNA interactions of a repressor. Wharton, R.P., Brown, E.L., Ptashne, M. Cell (1984) [Pubmed]
  3. Heterozygote detection in cystinosis, using leukocytes exposed to cystine dimethyl ester. Steinherz, R., Tietze, F., Triche, T., Modesti, A., Gahl, W.A., Schulman, J.D. N. Engl. J. Med. (1982) [Pubmed]
  4. Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA. Weber, B.L., Westin, E.H., Clarke, M.F. Science (1990) [Pubmed]
  5. Inducibility of transferrin receptors on friend erythroleukemic cells. Hu, H.Y., Gardner, J., Aisen, P. Science (1977) [Pubmed]
  6. Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. Wierzbicki, A.S., Solomon, H., Lumb, P.J., Lyttle, K., Lambert-Hammill, M., Jackson, G. Atherosclerosis (2006) [Pubmed]
  7. Electrode and cuvette for rapid continuous CO2 tension and pH measurement in blood. Katz, S.A., Roth, A.C., Feigl, E.O. J. Appl. Physiol. (1985) [Pubmed]
  8. Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. Farkas, E., Timmer, N.M., Domoki, F., Mihály, A., Luiten, P.G., Bari, F. Neurosci. Lett. (2005) [Pubmed]
  9. A new monitor with a zinc-oxide thin film semiconductor sensor for the measurement of volatile sulfur compounds in mouth air. Shimura, M., Yasuno, Y., Iwakura, M., Shimada, Y., Sakai, S., Suzuki, K., Sakamoto, S. J. Periodontol. (1996) [Pubmed]
  10. Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Martin, T.J., Buechler, N.L., Eisenach, J.C. Anesth. Analg. (2006) [Pubmed]
  11. A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Aguilera, R.J., Akira, S., Okazaki, K., Sakano, H. Cell (1987) [Pubmed]
  12. Mapping the topography of DNA wrapped around gyrase by nucleolytic and chemical probing of complexes of unique DNA sequences. Kirkegaard, K., Wang, J.C. Cell (1981) [Pubmed]
  13. A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization. Boyd, P.W., Watson, A.J., Law, C.S., Abraham, E.R., Trull, T., Murdoch, R., Bakker, D.C., Bowie, A.R., Buesseler, K.O., Chang, H., Charette, M., Croot, P., Downing, K., Frew, R., Gall, M., Hadfield, M., Hall, J., Harvey, M., Jameson, G., LaRoche, J., Liddicoat, M., Ling, R., Maldonado, M.T., McKay, R.M., Nodder, S., Pickmere, S., Pridmore, R., Rintoul, S., Safi, K., Sutton, P., Strzepek, R., Tanneberger, K., Turner, S., Waite, A., Zeldis, J. Nature (2000) [Pubmed]
  14. Selective proteolysis defines two DNA binding domains in yeast transcription factor tau. Marzouki, N., Camier, S., Ruet, A., Moenne, A., Sentenac, A. Nature (1986) [Pubmed]
  15. Detection in vivo of protein-DNA interactions within the lac operon of Escherichia coli. Nick, H., Gilbert, W. Nature (1985) [Pubmed]
  16. Ineffectiveness of topical idoxuridine in dimethyl sulfoxide for therapy for genital herpes. Silvestri, D.L., Corey, L., Holmes, K.K. JAMA (1982) [Pubmed]
  17. Effects of retinoic acid versus dimethyl sulfoxide on Friend erythroleukemia cell growth. I. Cell proliferation, RNA content, and protein content. Traganos, F., Bueti, C., Darzynkiewicz, Z., Melamed, M.R. J. Natl. Cancer Inst. (1984) [Pubmed]
  18. Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury. Ward, P.A., Till, G.O., Kunkel, R., Beauchamp, C. J. Clin. Invest. (1983) [Pubmed]
  19. Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene. Berdal, K.G., Bjørås, M., Bjelland, S., Seeberg, E. EMBO J. (1990) [Pubmed]
  20. Chemical probing of the tRNA--ribosome complex. Peattie, D.A., Herr, W. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  21. A proficient enzyme. Radzicka, A., Wolfenden, R. Science (1995) [Pubmed]
  22. Dimethyl sulfoxide stimulates tyrosine residue phosphorylation of rat liver epidermal growth factor receptor. Rubin, R.A., Earp, H.S. Science (1983) [Pubmed]
  23. B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Ephrussi, A., Church, G.M., Tonegawa, S., Gilbert, W. Science (1985) [Pubmed]
  24. Erythroid differentiation of clonal Rauscher erythroleukemia cells in response to erythropoietin or dimethyl sulfoxide. Sytkowski, A.J., Salvado, A.J., Smith, G.M., McIntyre, C.J., deBoth, N.J. Science (1980) [Pubmed]
  25. Role of transferrin, Fe, and transferrin receptors in myeloid leukemia cell growth. Studies with an antitransferrin receptor monoclonal antibody. Taetle, R., Rhyner, K., Castagnola, J., To, D., Mendelsohn, J. J. Clin. Invest. (1985) [Pubmed]
  26. Interferon-induced differentiation of U937 cells. Comparison with other agents that promote differentiation of human myeloid or monocytelike cell lines. Hattori, T., Pack, M., Bougnoux, P., Chang, Z.L., Hoffman, T. J. Clin. Invest. (1983) [Pubmed]
  27. Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide. Repine, J.E., Eaton, J.W., Anders, M.W., Hoidal, J.R., Fox, R.B. J. Clin. Invest. (1979) [Pubmed]
  28. Correlation between the carcinogenicities of nitrofuran derivatives and their destructive actions on sebaceous glands of mouse skin. Takizawa, H., Hozumi, M., Sugimura, T., Bryan, G.T. J. Natl. Cancer Inst. (1975) [Pubmed]
  29. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Wang, H., An, W., Cao, R., Xia, L., Erdjument-Bromage, H., Chatton, B., Tempst, P., Roeder, R.G., Zhang, Y. Mol. Cell (2003) [Pubmed]
  30. Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. DeForge, L.E., Fantone, J.C., Kenney, J.S., Remick, D.G. J. Clin. Invest. (1992) [Pubmed]
  31. Intracellular cystine loading inhibits transport in the rabbit proximal convoluted tubule. Salmon, R.F., Baum, M. J. Clin. Invest. (1990) [Pubmed]
  32. Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. Miller, R.A., Britigan, B.E. J. Clin. Invest. (1995) [Pubmed]
  33. Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant. Yamasaki, T., Klein, G., Ljunggren, H.G., Höglund, P., Ohlén, C., Petersson, M.G., Kärre, K. J. Natl. Cancer Inst. (1988) [Pubmed]
  34. Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice. Tessner, T.G., Cohn, S.M., Schloemann, S., Stenson, W.F. Gastroenterology (1998) [Pubmed]
  35. Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. Naumann, K., Fischer, A., Hofmann, I., Krauss, V., Phalke, S., Irmler, K., Hause, G., Aurich, A.C., Dorn, R., Jenuwein, T., Reuter, G. EMBO J. (2005) [Pubmed]
  36. Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Akamatsu, Y., Oettinger, M.A. Mol. Cell. Biol. (1998) [Pubmed]
  37. The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. Zhang, W., Deng, H., Bao, X., Lerach, S., Girton, J., Johansen, J., Johansen, K.M. Development (2006) [Pubmed]
  38. Effects of dimethyl sulfoxide on renal function in man. Muther, R.S., Bennett, W.M. JAMA (1980) [Pubmed]
  39. A dog model for acetaminophen-induced fulminant hepatic failure. Francavilla, A., Makowka, L., Polimeno, L., Barone, M., Demetris, J., Prelich, J., Van Thiel, D.H., Starzl, T.E. Gastroenterology (1989) [Pubmed]
  40. Very early abortion by prostaglandins. Mackenzie, I.Z., Embrey, M.P., Davies, A.J., Guillebaud, J. Lancet (1978) [Pubmed]
  41. DNA-directed oligomerization of the monomeric Ner repressor from the Mu-like bacteriophage D108. Kukolj, G., Tolias, P.P., Autexier, C., DuBow, M.S. EMBO J. (1989) [Pubmed]
  42. Alternating d(G-A) sequences form a parallel-stranded DNA homoduplex. Rippe, K., Fritsch, V., Westhof, E., Jovin, T.M. EMBO J. (1992) [Pubmed]
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