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Chemical Compound Review

dATP     [[[(2R,3S,5R)-5-(6- aminopurin-9-yl)-3...

Synonyms: deoxy-ATP, CHEMBL335538, CHEBI:16284, HMDB01532, AK-54718, ...
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High impact information on ATP

  • Both thymocyte subpopulations elevated in their dATP pools on incubation with microM concentrations of deoxyadenosine in the presence of erythro-9-[3-(2-hydroxynonyl)]adenosine, an inhibitor of adenosine deaminase [1].
  • These phenomena are believed to reflect accumulation of high intracellular concentrations of deoxyadenosine triphosphate (dATP) following phosphorylation of deoxyadenosine, inhibiting replicating T-cells [1].
  • 4. Affinity estimates of 15 other nucleotide analogues for the [35S]-ATP gamma S binding sites on the two recombinant P2X purinoceptor subtypes were surprisingly similar (less than 5 fold difference), the only exception being 2'-deoxy ATP which possessed 8 fold higher affinity for rat P2X2 than for human P2X1 purinoceptors [2].
  • The FeMo-co synthesis system specifically requires ATP, whereas both 1,N6-etheno-ATP and 2'-deoxy-ATP function in place of ATP in substrate reduction (M. F. Weston, S. Kotake, and L. C. Davis, Arch. Biochem. Biophys. 225:809-817, 1983) [3].
  • However, other ATP analogues, such as 2'-deoxy-ATP and 3'-deoxy-ATP and 2',3'-dideoxy-ATP, supported the reactivation of organelle and cell surface transport at similar, but markedly reduced, velocities [4].


  1. Purine deoxynucleoside toxicity in nondividing human lymphoid cells. Kefford, R.F., Fox, R.M. Cancer Res. (1982) [Pubmed]
  2. A comparison of the binding characteristics of recombinant P2X1 and P2X2 purinoceptors. Michel, A.D., Lundström, K., Buell, G.N., Surprenant, A., Valera, S., Humphrey, P.P. Br. J. Pharmacol. (1996) [Pubmed]
  3. Nucleotide and divalent cation specificity of in vitro iron-molybdenum cofactor synthesis. Chatterjee, R., Allen, R.M., Shah, V.K., Ludden, P.W. J. Bacteriol. (1994) [Pubmed]
  4. Cell surface and organelle transport share the same enzymatic properties in Reticulomyxa. Orokos, D.D., Travis, J.L. Cell Motil. Cytoskeleton (1997) [Pubmed]
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