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Chemical Compound Review:

Guvacoline methyl1,2,5,6- tetrahydropyridine-3...

Synonyms: Norarecoline, CHEMBL268808, SureCN3019132, CHEBI:100893, AC1L4NPV, ...

Sauerberg, P. et al., Giri, S. et al.

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High impact information on Guvacoline

The compounds were designed by bioisosteric replacement of the methyl ester groups of the muscarinic cholinergic agonists norarecoline and arecoline by the 3-methoxyisoxazole group, and their interactions with central and peripheral muscarinic receptors were tested in vitro [1].
The areca alkaloids comprise arecoline, arecaidine, guvacoline, and guvacine [2].

References

A novel class of conformationally restricted heterocyclic muscarinic agonists. Sauerberg, P., Larsen, J.J., Falch, E., Krogsgaard-Larsen, P. J. Med. Chem. (1986) [Pubmed]
A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Giri, S., Idle, J.R., Chen, C., Zabriskie, T.M., Krausz, K.W., Gonzalez, F.J. Chem. Res. Toxicol. (2006) [Pubmed]

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