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MeSH Review

Areca

 
 
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Disease relevance of Areca

 

Psychiatry related information on Areca

 

High impact information on Areca

 

Chemical compound and disease context of Areca

 

Biological context of Areca

 

Anatomical context of Areca

 

Associations of Areca with chemical compounds

  • Comparisons of the areca nut-related N-nitroso compounds and their precursor alkaloids, at concentrations up to 5 mM, indicate that 3-(N-nitrosomethylamino)propionaldehyde is the most potent on a molar basis to decrease both survival and thiol content and to cause significant formation of DNA single strand breaks [22].
  • Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring [23].
  • Effects of betel nut and fermented fish on the thiamin status of northeastern Thais [24].
  • Areca nut (AN), a BQ component, modulates arachidonic acid (AA) metabolism, which is crucial for platelet function [25].
  • Abstention from both betel nut chewing and raw fermented fish consumption resulted in a significant reduction of thiamin pyrophosphate effect [24].
 

Gene context of Areca

  • CONCLUSIONS: Taken together, these results suggest that COX-2 expression is significantly up-regulated in OSF tissues from areca quid chewers and arecoline may among other constituents be responsible for the enhanced COX-2 expression in vivo [26].
  • However, the staining rate of p53 in OLP was higher in areca quid (AQ) chewers compared to abstainers (P = .001), and the mean PCNA LI in atrophic cases was higher than that in hypertrophic cases (P = .029) [27].
  • To verify whether arecoline, a major areca nut alkaloid, could affect TIMP or MMP production by human BMFs, Western blots and gelatine zymography were used [28].
  • Thus, IL-8 may be a vital participant in the cascade of interacting cytokines during smoking and areca quid chewing, inducing inflammation in oral cancer [29].
  • A significant correlation was observed between MDM2 protein and p53 expression in 38 cases with an areca quid (AQ) chewing habit (P=0.032) [30].
 

Analytical, diagnostic and therapeutic context of Areca

References

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  14. Serum antioxidant vitamin levels of people in Khon Kaen, northeastern Thailand. Sripanidkulchai, B., Vaikrutta, S., Sriamporn, S., Vatanasapt, P., Sripanidkulchai, K., Sirisangtrakul, W. Asian Pac. J. Cancer Prev. (2003) [Pubmed]
  15. The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation. Chang, M.C., Wu, H.L., Lee, J.J., Lee, P.H., Chang, H.H., Hahn, L.J., Lin, B.R., Chen, Y.J., Jeng, J.H. J. Biol. Chem. (2004) [Pubmed]
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  20. Relationship between cellular levels of beta-carotene and sensitivity to genotoxic agents. Stich, H.F., Dunn, B.P. Int. J. Cancer (1986) [Pubmed]
  21. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Lodge, D., Johnston, G.A., Curtis, D.R., Brand, S.J. Brain Res. (1977) [Pubmed]
  22. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Sundqvist, K., Liu, Y., Nair, J., Bartsch, H., Arvidson, K., Grafström, R.C. Cancer Res. (1989) [Pubmed]
  23. Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring. Boucher, B.J., Ewen, S.W., Stowers, J.M. Diabetologia (1994) [Pubmed]
  24. Effects of betel nut and fermented fish on the thiamin status of northeastern Thais. Vimokesant, S.L., Hilker, D.M., Nakornchai, S., Rungruangsak, K., Dhanamitta, S. Am. J. Clin. Nutr. (1975) [Pubmed]
  25. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. Jeng, J.H., Chen, S.Y., Liao, C.H., Tung, Y.Y., Lin, B.R., Hahn, L.J., Chang, M.C. Free Radic. Biol. Med. (2002) [Pubmed]
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  27. Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing. Lee, J.J., Kuo, M.Y., Cheng, S.J., Chiang, C.P., Jeng, J.H., Chang, H.H., Kuo, Y.S., Lan, W.H., Kok, S.H. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2005) [Pubmed]
  28. Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis. Chang, Y.C., Yang, S.F., Tai, K.W., Chou, M.Y., Hsieh, Y.S. Oral Oncol. (2002) [Pubmed]
  29. Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments. Cheng, Y.A., Shiue, L.F., Yu, H.S., Hsieh, T.Y., Tsai, C.C. The Kaohsiung journal of medical sciences. (2000) [Pubmed]
  30. MDM2 expression in areca quid chewing-associated oral squamous cell carcinomas in Taiwan. Huang, J.S., Ho, T.J., Chiang, C.P., Kok, S.H., Kuo, Y.S., Kuo, M.Y. J. Oral Pathol. Med. (2001) [Pubmed]
  31. Determination of arecoline (areca nut alkaloid) and nicotine in hair by high-performance liquid chromatography/electrospray quadrupole mass spectrometry. Marchei, E., Durgbanshi, A., Rossi, S., Garcia-Algar, O., Zuccaro, P., Pichini, S. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  32. Absorption of intestinal free cholesterol is lowered by supplementation of Areca catechu L. extract in rats. Park, Y.B., Jeon, S.M., Byun, S.J., Kim, H.S., Choi, M.S. Life Sci. (2002) [Pubmed]
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