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Chemical Compound Review:

CBDA 2,4-dihydroxy-3-[(1S,6R)-3- methyl-6-prop-1...

Synonyms: cannabidiolate, CHEMBL498672, CHEBI:3359, AG-K-27144, CHEBI:611083, ...

Molnár, J. et al., Yoshimatsu, K. et al., Taura, F. et al.

Yoshimatsu, Iida, Kitazawa, Sekine, Kojoma, Makino, Kiuchi,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cannabidiolic acid

Among the cannabinoid derivatives the cannabinol and cannabispirol increased drug accumulation, while cannabidiolic acid and delta-8-THC, delta-9-THC and tetrahydro-cannabinol reduced drug accumulation in multidrug resistant mouse lymphoma cells [1].

Psychiatry related information on Cannabidiolic acid

To investigate growth characteristics of C. sativa, two varieties, cannabidiolic acid (CBDA)-rich (CBDA-type) which being cultivated for fiber production and delta9-tetrahydrocannabinolic acid (THCA)-rich (THCA-type) which is used for drug abuse, were cultivated from seeds under the same growth environment in a phytotron [2].

High impact information on Cannabidiolic acid

We identified a unique enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid (CBDA) in Cannabis sativa L [3].
Some cannabinoid derivatives such as cannabinol, cannabispirol and cannabidiol increased drug accumulation, while cannabidiolic acid, delta-9-THC and tetrahydro-cannabidiolic acid reduced drug accumulation of the human mdr1-gene transfected mouse lymphoma cells [1].

References

Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates. Molnár, J., Szabó, D., Pusztai, R., Mucsi, I., Berek, L., Ocsovszki, I., Kawata, E., Shoyama, Y. Anticancer Res. (2000) [Pubmed]
Growth characteristics of Cannabis sativa L. cultivated in a phytotron and in the field. Yoshimatsu, K., Iida, O., Kitazawa, T., Sekine, T., Kojoma, M., Makino, Y., Kiuchi, F. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences. (2004) [Pubmed]
Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid. Taura, F., Morimoto, S., Shoyama, Y. J. Biol. Chem. (1996) [Pubmed]

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