The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cannabis


Psychiatry related information on Cannabis


High impact information on Cannabis


Chemical compound and disease context of Cannabis

  • As cannabigerol lacked these toxicities, it appears that the ocular hypotensive effect of this cannabinoid is somewhat dissociable from both the adverse central and ocular effects accompanying marihuana intake [13].
  • Despite marked contrasts in potency, toxicity and therapeutic potential as a result of these differences it is proposed that the proper pharmacologic classification of both drugs is in the sedative group based on their activity at non-toxic levels rather than regarding marihuana as a primary hallucinogen as presently done in many texts [14].

Biological context of Cannabis

  • However, plasma prolactin levels were significantly lower at 60 to 120 min (P less than .01) and 150 to 180 min (P less than .05) after marihuana smoking during the luteal phase of the menstrual cycle [15].
  • This is a report of the results of a placebo-controlled study in which the effects of the interaction between ethanol and marihuana on drug plasma concentrations, subjective ratings of intoxication, heart rate acceleration, and psychomotor performance were investigated [6].
  • Maternal exposure to delta 9-tetrahydrocannabinol (THC), the major psychoactive component in marihuana, or to the non-psychoactive cannabinol (CBN) or cannabidiol (CBD) alters male reproductive functions and brain biogenic amines in male and female offspring [16].
  • In previous study the major psychoactive ingredient of marihuana (delta 1-THC) has been shown to inhibit ovarian prostaglandin synthesis when administered to normally cycling rats in the early afternoon of proestrus [17].
  • Cannabidiol CBD, a non-psychoactive constituent of marihuana, has been reported to possess essentially no affinity for cannabinoid CB1 receptor binding sites in the brain [18].

Anatomical context of Cannabis


Associations of Cannabis with chemical compounds


Gene context of Cannabis

  • The basal and stimulated levels of LH were reduced in marihuana users, whereas FSH and PRL levels and responses were not different from the control subjects [28].
  • Synthetic cannabinoids, the psychoactive components of the Cannabis sativa (marijuana) plant and their endogenous counterparts, act through two G protein-coupled receptors, CB1 and CB2 [29].
  • Ten male chronic marihuana users and 10 age- and sex-matched healthy volunteers were studied by measuring hormone levels before and after i.v. administration of thyrotropin releasing hormone (TRH) and gonadotropin releasing hormone (GnRH) [28].
  • Synthetic cannabinoids, the psychoactive components of the Cannabis sativa (marijuana) and their endogenous counterparts, act through two G protein-coupled receptors, CB1 and CB2 [30].
  • Delta9-Tetrahydrocannabinol (Delta9-THC) and (-)-cannabidiol are major constituents of the Cannabis sativa plant with different pharmacological profiles: (-)-Delta9-tetrahydrocannabinol, but not (-)-cannabidiol, activates cannabinoid CB1 and CB2 receptors and induces psychoactive and peripheral effects [31].

Analytical, diagnostic and therapeutic context of Cannabis


  1. Effect of delta-9-tetrahydrocannabinol on uterine and vaginal cytology of ovariectomized rats. Solomon, J., Cocchia, M.A., DiMartino, R. Science (1977) [Pubmed]
  2. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., Izzo, A.A. J. Neurochem. (2004) [Pubmed]
  3. Prolonged cataleptogenic effects of potentized homoeopathic drugs. Sukul, N.C., Bala, S.K., Bhattacharyya, B. Psychopharmacology (Berl.) (1986) [Pubmed]
  4. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. Colasanti, B.K., Brown, R.E., Craig, C.R. Gen. Pharmacol. (1984) [Pubmed]
  5. Quantitative evaluation of spermatogenesis in mice following chronic exposure to cannabinoids. Patra, P.B., Wadsworth, R.M. Andrologia (1991) [Pubmed]
  6. Interaction between marihuana and ethanol: effects on psychomotor performance. Perez-Reyes, M., Hicks, R.E., Bumberry, J., Jeffcoat, A.R., Cook, C.E. Alcohol. Clin. Exp. Res. (1988) [Pubmed]
  7. Transdermal nicotine alters some of marihuana's effects in male and female volunteers. Penetar, D.M., Kouri, E.M., Gross, M.M., McCarthy, E.M., Rhee, C.K., Peters, E.N., Lukas, S.E. Drug and alcohol dependence. (2005) [Pubmed]
  8. Review of Marihuana and Medicine. Nahas, G., Sutin, K., Bennett, W.M. N. Engl. J. Med. (2000) [Pubmed]
  9. Letter: Normal plasma testosterone concentrations after marihuana smoking. Schaefer, C.F., Gunn, C.G., Dubowski, K.M. N. Engl. J. Med. (1975) [Pubmed]
  10. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Pagotto, U., Marsicano, G., Cota, D., Lutz, B., Pasquali, R. Endocr. Rev. (2006) [Pubmed]
  11. Marihuana and epilepsy. Feeney, D.M. Science (1977) [Pubmed]
  12. Anticonvulsant nature of marihuana smoking. Consroe, P.F., Wood, G.C., Buchsbaum, H. JAMA (1975) [Pubmed]
  13. Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol. Colasanti, B.K., Craig, C.R., Allara, R.D. Exp. Eye Res. (1984) [Pubmed]
  14. Marihuana vs. alcohol: a pharmacologic comparison. Truitt, E.B. Adv. Exp. Med. Biol. (1975) [Pubmed]
  15. Acute effects of marihuana smoking on prolactin levels in human females. Mendelson, J.H., Mello, N.K., Ellingboe, J. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  16. Early cannabinoid exposure influences neuroendocrine and reproductive functions in mice: II. Postnatal effects. Dalterio, S., Steger, R., Mayfield, D., Bartke, A. Pharmacol. Biochem. Behav. (1984) [Pubmed]
  17. The suppressive effect of delta-1-tetrahydrocannabinol on the steroidogenic activity of rat granulosa cells in culture. Lewysohn, O., Cordova, T., Nimrod, A., Ayalon, D. Horm. Res. (1984) [Pubmed]
  18. The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor. Reggio, P.H., Bramblett, R.D., Yuknavich, H., Seltzman, H.H., Fleming, D.N., Fernando, S.R., Stevenson, L.A., Pertwee, R.G. Life Sci. (1995) [Pubmed]
  19. Ingested marihuana-filled balloons. Dassel, P.M., Punjabi, E. Gastroenterology (1979) [Pubmed]
  20. Effects of acute and subchronic delta 9-tetrahydrocannabinol administration on the plasma catecholamine, beta-endorphin, and corticosterone levels and splenic natural killer cell activity in rats. Patel, V., Borysenko, M., Kumar, M.S., Millard, W.J. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  21. Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency. Thomas, B.F., Compton, D.R., Martin, B.R. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  22. Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes. Hillard, C.J., Bloom, A.S., Houslay, M.D. Biochem. Pharmacol. (1986) [Pubmed]
  23. Cannabinoid physiology and pharmacology: 30 years of progress. Howlett, A.C., Breivogel, C.S., Childers, S.R., Deadwyler, S.A., Hampson, R.E., Porrino, L.J. Neuropharmacology (2004) [Pubmed]
  24. Marihuana and setting. Hollister, L.E., Overall, J.E., Gerber, M.L. Arch. Gen. Psychiatry (1975) [Pubmed]
  25. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Maccarrone, M., Finazzi-Agró, A. Cell Death Differ. (2003) [Pubmed]
  26. Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid. Taura, F., Morimoto, S., Shoyama, Y. J. Biol. Chem. (1996) [Pubmed]
  27. Influence of cannabidiol on delta-9-tetrahydrocannabinol effects. Dalton, W.S., Martz, R., Lemberger, L., Rodda, B.E., Forney, R.B. Clin. Pharmacol. Ther. (1976) [Pubmed]
  28. Chronic effects of marihuana smoking on luteinizing hormone, follicle-stimulating hormone and prolactin levels in human males. Vescovi, P.P., Pedrazzoni, M., Michelini, M., Maninetti, L., Bernardelli, F., Passeri, M. Drug and alcohol dependence. (1992) [Pubmed]
  29. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Park, B., Gibbons, H.M., Mitchell, M.D., Glass, M. Placenta (2003) [Pubmed]
  30. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Park, B., Gibbons, H.M., Mitchell, M.D., Glassa, M. Placenta (2003) [Pubmed]
  31. (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. Fride, E., Feigin, C., Ponde, D.E., Breuer, A., Hanus, L., Arshavsky, N., Mechoulam, R. Eur. J. Pharmacol. (2004) [Pubmed]
  32. Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis. Lindgren, J.E., Ohlsson, A., Agurell, S., Hollister, L., Gillespie, H. Psychopharmacology (Berl.) (1981) [Pubmed]
  33. Ethanol increases plasma Delta(9)-tetrahydrocannabinol (THC) levels and subjective effects after marihuana smoking in human volunteers. Lukas, S.E., Orozco, S. Drug and alcohol dependence. (2001) [Pubmed]
WikiGenes - Universities