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Chemical Compound Review:

SureCN197850 3-(3,4-dihydroxy-5-methoxy- phenyl)prop-2...

Synonyms: ACMC-20mdkt, AC1L4NWF, CTK0D4612, 110642-42-7, 3,4-dihydroxy-5-methoxycinnamic acid

Li, L. et al., Chapple, C.C. et al., Humphreys, J.M. et al., Tiimonen, H. et al.

Tiimonen, Aronen, Laakso, Saranpää, Chiang, Ylioja, Roininen, Häggman,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C05619

These lines carry COMT (caffeate/5-hydroxyferulate O-methyltransferase) gene from Populus tremuloides driven by constitutive promoter 35S CaMV (cauliflower mosaic virus) or UbB1 (ubiquitin promoter from sunflower) [1].

High impact information on C05619

As determined by in vivo radiotracer feeding experiments, precursor supplementation studies, and enzymatic assays, the defect in the sin1 mutants appears to block the conversion of ferulate to 5-hydroxyferulate in the general phenylpropanoid pathway [2].
According to current models of the phenylpropanoid pathway, F5H catalyzes the hydroxylation of ferulate to 5-hydroxyferulate; however, our studies indicate that the enzyme also uses coniferaldehyde and coniferyl alcohol as substrates [3].
S-Adenosyl-L-methionine-dependent caffeate O-methyltransferase (COMT, EC 2.1.1.6) has traditionally been thought to catalyze the methylation of caffeate and 5- hydroxyferulate for the biosynthesis of syringyl monolignol, a lignin constituent of angiosperm wood that enables efficient lignin degradation for cellulose production [4].

References

Does lignin modification affect feeding preference or growth performance of insect herbivores in transgenic silver birch (Betula pendula Roth)? Tiimonen, H., Aronen, T., Laakso, T., Saranpää, P., Chiang, V., Ylioja, T., Roininen, H., Häggman, H. Planta (2005) [Pubmed]
An Arabidopsis mutant defective in the general phenylpropanoid pathway. Chapple, C.C., Vogt, T., Ellis, B.E., Somerville, C.R. Plant Cell (1992) [Pubmed]
New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase. Humphreys, J.M., Hemm, M.R., Chapple, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
5-hydroxyconiferyl aldehyde modulates enzymatic methylation for syringyl monolignol formation, a new view of monolignol biosynthesis in angiosperms. Li, L., Popko, J.L., Umezawa, T., Chiang, V.L. J. Biol. Chem. (2000) [Pubmed]

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